5L83,2KQ7,2KWC,2LI5,3RUI,3VH3,2ZPN,3VXW


Conserved Protein Domain Family
Ubl_ATG8
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cd16128: Ubl_ATG8 
ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae Atg8p and related proteins; sub-family of the autophagy-related 8 (ATG8) family
The ATG8 family of proteins constitutes a single member in Saccharomyces cerevisiae, Atg8p, and multiple homologs in higher eukaryotes. These proteins are multifunctional ubiquitin-like (Ubl) key regulators of autophagy. ATG8 is characterized by a C-terminal ubiquitin-like (Ubl) domain with a short N-terminal extension. The covalent attachment of ATG8 to phosphatidylethanolamine (PtdEth) at the autophagosomal membrane places it at a crucial juncture during autophagosome formation. ATG Ubl proteins such as Saccharomyces cerevisiae Atg8p undergo a unique Ubl conjugation, a process essential for autophagosome formation.
Links
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Statistics
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PSSM-Id: 340545
Aligned: 22 rows
Threshold Bit Score: 182.661
Created: 2-Apr-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:Atg7 interaction site [polypeptide binding site]
Evidence:
  • Comment:Atg8-Atg7 interaction site
  • Comment:The E1-like enzyme Atg7 activates the autophagic ubiquitin-like (Ubl) molecule Atg8.
  • Structure:3RUI; Saccharomyces cerevisiae Atg8p interacts with Atg7p, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #        ##       #  #        ## ### ###    ## ### #  ### ###  
5L83_A        10 LERRQAEAARIREKYpDRIPVIVEKAERsDIPDIDKKKYLVPADLTVGQFVYVVRKRIKLsAEKAIFIFVKNILPPTAAM 89  potato
3RUI_B        13 FEKRKAESERIADRFkNRIPVICEKAEKsDIPEIDKRKYLVPADLTVGQFVYVIRKRIMLpPEKAIFIFVNDTLPPTAAL 92  Saccharomyces c...
ABA01133      15 LDKRKAEAARIKEKYpDRIPVIVEKAERsDIPDIDKKKYLVPSDLTVGQFVYVIRKRIKLsPEKAIFIFVKNVLPPTAAL 94  Chlamydomonas i...
ABK25196      12 LEKRKAEAARIRDKYpDRIPVIVEKAERsDIPNIDKKKYLVPADLTVGQFVYVIRKRIKLsAEKAIFIFVNNVLPPTAAI 91  Sitka spruce
XP_001757121  12 LEKRQAEAARIRDKYpDRIPVIVEKAEKsDIPDIDKKKYLVPADLTVGQFVYVIRKRIKLsSEKAIFIFVKNVLPPTAAM 91  Physcomitrella ...
XP_002978705  18 LEKRKAEAARIREKYpERIPVIVEKAERsDIPNIDKKKYLVPADLTVGQFVYVIRKRIKLsAEKAIFIFVNNVLPPTAGI 97  Selaginella moe...
XP_003074617  41 RNKRSSESARIRTKYgDRVPVIVERAEKsDIPALDKKKYLVPADLTVGQFVYVIRKRIKLsAEKAIFIFVNNVLPPTGTL 120 Ostreococcus tauri
EJK45363     105 TEKRKSEAERIRGKYpDRVPVICEKADRsDIPDIDKKKYLVPADLTVGQFHYVIRKRIQLaPEKALFLFCSNNIPPNAAL 184 Thalassiosira o...
XP_004343574  11 FEKRRTEAQRIRQKYpDRIPVIVERDDKsDISDIDKKKYLVPADLTVGQFVYVIRKRIKLsPEKAIFIFVKNVLPPTSAA 90  Capsaspora owcz...
XP_005827281  15 LERRKAEASRMREKYpDRIPVIVEKAAGgDLPDIDKKKYLVPTDLTVGQFVHVIRKRIKLaPEKAIFIFVNNVLPPTAAL 94  Guillardia thet...

Feature 1                             ##
5L83_A        90 MSAIYEEHKDEDGFLYMTYSGEN 112 potato
3RUI_B        93 MSAIYQEHKDKDGFLYVTYSGEN 115 Saccharomyces cerevisiae S288c
ABA01133      95 MSSIYEDHKDEDGFLYITYSGEN 117 Chlamydomonas incerta
ABK25196      92 MSSIYDEHKDEDGFLYVTYSGEN 114 Sitka spruce
XP_001757121  92 MSSIYDEHKDEDGFLYFTYSGEN 114 Physcomitrella patens
XP_002978705  98 MSAIYDEHKDEDGFLYVTYSGEN 120 Selaginella moellendorffii
XP_003074617 121 MSAIYEEHKDEDGFLYITYSGEN 143 Ostreococcus tauri
EJK45363     185 MSTVYEEQKDEDGFLYVQYSGES 207 Thalassiosira oceanica
XP_004343574  91 MATIYEEHKDDDGFLYITYSGEN 113 Capsaspora owczarzaki ATCC 30864
XP_005827281  95 MSTIYEEQKDEDGFLYITYNGES 117 Guillardia theta CCMP2712

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