4QAM


Conserved Protein Domain Family
RPGR1_C

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pfam18111: RPGR1_C 
Retinitis pigmentosa G-protein regulator interacting C-terminal
This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.
Statistics
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PSSM-Id: 465655
Aligned: 7 rows
Threshold Bit Score: 184.157
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4QAM_B         29 DSEKXCIEIVSLAFYPEAEVXSDENI--KQVYVEYKFYDLPLsetETPVSLRKPRA-GEEIHFHFSKVIDLDPQEQQGRR 105  human
1_pfamImport    1 DPDTIRISVNHLTLDNDTSIWGDTSI--EQLFVEYEFMGEVE---ETPNAVTKPTTkDSKLVYNFTKESKVDKAKNSNKR 75  
XP_002760995 1098 PSEKIRIEIIALSL-NDSQVTMDDTI--QRLFIECRFCSLPAe--ETPVSLPKPKS-GQWVYYNYSNVIYVDKENNQAKR 1171
KYO39321      933 ATARICIEVISLSLWPGPEAMASG----QRVYVEYRFPGVPLaetETPVSLRLPRV-GEWLYFHFSKVIDLDVGLASAQQ 1007
EEN68317     1050 ANNMVTVTIFEFQLNGGAAVLDDGNV--RMLFVEYRFLGRPPeetETPFSLPKPSRpNQPIKYNFRRVFHVDAENNELTR 1127
VDP36909      145 DDNHVKIELHGLQLTDLSKLSKMNPSlpNQLFIEYSFLGYKEp---------------------FETAFPVDFTKNYERR 203 
KMQ89061      499 EKDTIIIEIASMQLLNESFIMQDDEI--HLLYVEYSFLGRRGedmET-VSVEKPKTaSQEMFYNFKKN----EKTHSVER 571 
4QAM_B        106 RFLFDXLNGQDpdqGHLKFTVVSDPL--DEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPE------DLATPIGR 177  human
1_pfamImport   76 EVLTDMLRNRQ---TTFKLTVVSEPT--NQEDGDCEEIGAASVDLASILDSGRDIIGSDVIVKDLR------NENETVGK 144 
XP_002760995 1172 DILKAVLQKQEipnRSIRFTVVSDPPe-DEQDLECEDIGVAHVHLADIFQEGRDLIEQNIDVFDAR------ADGKGIGK 1244
KYO39321     1008 ETLQAMLQAEEpqqSWLQFVVVSEPL--PGTGGECEDLGIAYVDLREILWTGNDVLEHDLDVFSSL------ALGSIIGK 1079
EEN68317     1128 DYLISMLLPGDpsqGRIKFTVVNEPE--D-EEGECADIGHAYVDLKQILEKGADVVEQDIDVVDVN------DEKEVIGA 1198
VDP36909      204 QYLASYLLPEDpnnGNLIFIIVSEPStsTTQSAECEEIGYAMINIRQIIQDNCDIDHVFIPITAAKtvdgetESLNEIGR 283 
KMQ89061      572 NILRSMLVESTs--PNVKFIIISEPLpeETEVKECEEVGYAIFNIKKYALG-DGSRDVSLPIKDDR--------NRQIGT 640 
4QAM_B        178 LKVSLQAAAVLHAIYKE 194  human
1_pfamImport  145 LNLNVEALAVLRVIKNE 161 
XP_002760995 1245 LRVTVEALHALRSVYEQ 1261
KYO39321     1080 LKVSVEAAAALRAVYWE 1096
EEN68317     1199 LNISVEALAALRAVQRE 1215
VDP36909      284 LCVSFYGLSALRAIIAE 300 
KMQ89061      641 LKIVVSGFDAIRQCLSD 657 
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