4QAM


Conserved Protein Domain Family
RPGR1_C
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pfam18111: RPGR1_C (this model, PSSM-Id:407945 is obsolete and has been replaced by 465655)
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Retinitis pigmentosa G-protein regulator interacting C-terminal
This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.
Links
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Statistics
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PSSM-Id: 407945
Aligned: 8 rows
Threshold Bit Score: 185.672
Created: 28-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4QAM_B         29 DSEKXCIEIVSLAFYPEAEVXSDENI--KQVYVEYKFYDLPLSETETPVSLRKPRA-GE--EIHFHFSKVIDLDPQeqQG 103  human
1_pfamImport    1 NEDTIIINIAQLTIDQDAALITDDSL--HRLFIEYQFLGIAQEELETPFSLPKPGP-NGpfELSYNFHKVIHIDGD--MT 75  
2_pfamImport    1 DPDTIRISVNHLTLDNDTSIWGDTSI--EQLFVEYEFMGEVE---ETPNAVTKPTTkDS--KLVYNFTKESKVDKAknSN 73  
VDP36909      145 DDNHVKIELHGLQLTDLSKLSKMNPSlpNQLFIEYSFLGYKEP-----------------------FETAFPVDFTknYE 201  Schistosoma c...
KMQ89061      499 EKDTIIIEIASMQLLNESFIMQDDEI--HLLYVEYSFLGRRGEDMET-VSVEKPKTaSQ--EMFYNFKKN----EKthSV 569  Lasius niger
XP_002760995 1098 PSEKIRIEIIALSL-NDSQVTMDDTI--QRLFIECRFCSLPAE--ETPVSLPKPKS-GQ--WVYYNYSNVIYVDKEnnQA 1169 white-tufted-...
EEN68317     1050 ANNMVTVTIFEFQLNGGAAVLDDGNV--RMLFVEYRFLGRPPEETETPFSLPKPSRpNQ--PIKYNFRRVFHVDAEnnEL 1125 Florida lancelet
KYO39321      933 ATARICIEVISLSLWPGPEAMASG----QRVYVEYRFPGVPLAETETPVSLRLPRV-GE--WLYFHFSKVIDLDVGlaSA 1005 American alli...

4QAM_B        104 RRRFLFDXLNGQDPDQGHLKFTVVSDPL--De--EKKECEEVGYAYLQLWQILESGRDILEQELDIVSPE------DLAT 173  human
1_pfamImport   76 KRNYLADFLRPDHSEQGRLRFTVVSEPP--DefqEDGDCIEVGYAYVDLRALLEEGRDLTDTDIEVVNVH------DESQ 147 
2_pfamImport   74 KREVLTDMLRNRQ---TTFKLTVVSEPT--Nq--EDGDCEEIGAASVDLASILDSGRDIIGSDVIVKDLR------NENE 140 
VDP36909      202 RRQYLASYLLPEDPNNGNLIFIIVSEPStsTt--QSAECEEIGYAMINIRQIIQDNCDIDHVFIPITAAKtvdgetESLN 279  Schistosoma c...
KMQ89061      570 ERNILRSMLVEST--SPNVKFIIISEPLpeEt--EVKECEEVGYAIFNIKKYALG-DGSRDVSLPIKDDR--------NR 636  Lasius niger
XP_002760995 1170 KRDILKAVLQKQEIPNRSIRFTVVSDPPe-De--QDLECEDIGVAHVHLADIFQEGRDLIEQNIDVFDAR------ADGK 1240 white-tufted-...
EEN68317     1126 TRDYLISMLLPGDPSQGRIKFTVVNEPE--D---EEGECADIGHAYVDLKQILEKGADVVEQDIDVVDVN------DEKE 1194 Florida lancelet
KYO39321     1006 QQETLQAMLQAEEPQQSWLQFVVVSEPL--Pg--TGGECEDLGIAYVDLREILWTGNDVLEHDLDVFSSL------ALGS 1075 American alli...

4QAM_B        174 PIGRLKVSLQAAAVLHAIYKE 194  human
1_pfamImport  148 PVGSLGVTVWCVAALRAIQRE 168 
2_pfamImport  141 TVGKLNLNVEALAVLRVIKNE 161 
VDP36909      280 EIGRLCVSFYGLSALRAIIAE 300  Schistosoma curassoni
KMQ89061      637 QIGTLKIVVSGFDAIRQCLSD 657  Lasius niger
XP_002760995 1241 GIGKLRVTVEALHALRSVYEQ 1261 white-tufted-ear marmoset
EEN68317     1195 VIGALNISVEALAALRAVQRE 1215 Florida lancelet
KYO39321     1076 IIGKLKVSVEAAAALRAVYWE 1096 American alligator
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