1WVG


Conserved Protein Domain Family
CDP_4_6_dhtase

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TIGR02622: CDP_4_6_dhtase 
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CDP-glucose 4,6-dehydratase
Members of this protein family are CDP-glucose 4,6-dehydratase from a variety of Gram-negative and Gram-positive bacteria. Members typically are encoded next to a gene that encodes a glucose-1-phosphate cytidylyltransferase, which produces the substrate, CDP-D-glucose, used by this enzyme to produce CDP-4-keto-6-deoxyglucose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Statistics
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PSSM-Id: 274236
Aligned: 13 rows
Threshold Bit Score: 582.725
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WVG_A         6 FWQGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRLNDLMEs-------HIGDIRDFEKLRSSIAE 78  Salmonella ente...
AAS70722       5 IYKNKKVLVTGHTGFKGSWLVIWLQSLGAEVAGFSLGLPTSPNHFELLNLDKKIKd-------YRGDIRDRASLSQAIDE 77  Leptospira inte...
AAO76457       6 VYQGKKVLVTGNTGFKGSWLSTWLLMMGADVYGYSSDIPTDPSMFETLKLKDKLHh-------CFGDIRDKAKLNEFVQK 78  Bacteroides the...
AAP10451       9 AFYGKTILITGHTGFKGSWLSLWLNELGATVIGYSLDPKNKNDNFNITNLQNNIId-------IRGDIRDFNKLNKVFTD 81  Bacillus cereus...
CAI38723       5 IYENTKVFLTGHTGFKGSWLGLWLHNLGAKVDGYSLQPNAKINHFDLLGGERLYEn------sYFSDINDAIKLEKALIN 78  Campylobacter j...
CAE19662      10 FWNKKKVIITGHTGFKGSWLSYWLLQMGANIYGISLEPITSPNLFEELKLQQKINh-------HVTDITNQSLLEKLISD 82  Prochlorococcus...
P26397         6 FWQGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRLNDLMe-------sHIGDIRDFEKLRNSIAE 78  Salmonella ente...
AAS42304       6 FWNKKKVFITGHTGFKGSWLTLFLTSLGAEVVGFSSHPPSIPNLFEQCNVAKECi-------tIHGDITDYDSLLHALKH 78  Bacillus cereus...
BAD79631       5 FWRDRQVLITGHTGFKGSWLTLWLLMQGADVWGYALPPESERSLFTALDLANQRQagwgyfqyRLGEMNDAEALRQWVEQ 84  Synechococcus e...
WP_011137439   5 FWRGRKVFLTGHTGFKGGWLSLWLADMGAEVHGYSLPPEQSPALFEAAGVGGRTm-------gMLADIRDAAALADAMRS 77  Chromobacterium...
WP_011088720  10 FWTGKRVLVTGHTGFKGGWMVAWLRHLGAEVAGLALPPSTTPNLFDLAQTARDTv-------sVFADIRDPLAVKAVFDR 82  Bradyrhizobium ...
WP_010871532   6 FWQGKSVFLTGHTGFKGSWLTLWLSQLGAKVSGYSLDPLTNPNLCELAEIAKCLRs------dTRADVNDLANLQKAIAE 79  Synechocystis s...
WP_010976067   9 FWAGKRVLLTGHTGFKGSWAGVWLKEMGAHVTGYALPPASRPSLHDLLHPNEAPg-------gQFGDIRDGEALATIARK 81  Sinorhizobium m...
1WVG_A        79 FKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQVGNIKAVVNITSDKCYDNR-EWVWGYRENEPMGGYDPY 157 Salmonella ente...
AAS70722      78 FKPQVIFHMAAQALVRKSYQDPVATFEINIMGMINLLDVIRTKSFVEATILITSDKAYRND-EWCWGYRETDVLGGHDPY 156 Leptospira inte...
AAO76457      79 VKPDFIFHLAAQAIVSTSYKFPFDTITTNVVGTASVLEAICNITWHCTCVLITSDKAYDNV-EWIWGYRETDAMGGKDVY 157 Bacteroides the...
AAP10451      82 YKPEIVFHLAAQPLVKYSYEYPRETYEVNVVGTMNVLEAIRLHESAKIGIMVTSDKCYENK-EWPWGYREIDPMGGHDIY 160 Bacillus cereus...
CAI38723      79 SDPEIIFHLAAQPLVRKSYQDPYNTFQTNTIGTLNILNISRKLKNLKAIVLITTDKVYKNK-EWFWGYRESDTLGGYDPY 157 Campylobacter j...
CAE19662      83 IQPDIIFHMAAQPLVIESYLEPLKTWETNVMGTFNLLNSLKFIKNKCVCICITTDKVYRNN-DRENYFKETDPLGGHDPY 161 Prochlorococcus...
P26397        79 FKPEIVFHMAAQPLVRLSYEQPIETYSTNVMGTVHLLETVKQVGNIKAVVNITSDKCYDNR-EWVWGYRENEPMGGYDPY 157 Salmonella ente...
AAS42304      79 HNPDILFHLAAQPIVTKSYKNPIETFKTNVLGTVHVLEAAKHIESIRGIINVTSDKCYENDgSGNRAFVEIDRLGGFDPY 158 Bacillus cereus...
BAD79631      85 AQPEVVFHLAAQPLVRRSYADPLGTWQTNVLGSLQLLEALKSLQHPCAMVMVTTDKVYENR-EWVYGYRETDCLGGHDPY 163 Synechococcus e...
WP_011137439  78 CRPSIVFHLAAQPLVRHSYADPLGTFTTNVMGTANLLDAARHCPGVEAVVAVTTDKCYENH-EWPWAYRESDALGGHDPY 156 Chromobacterium...
WP_011088720  83 FQPEIVFHMAAQAIVRASYDDPVGTYATNVMGTVHVFEAVRTSG-VRVVVNVTSDKCYDNK-EWVWGYRETDPLGGKDPY 160 Bradyrhizobium ...
WP_010871532  80 ARPEIVFHLAAQPLVRRSYRDPVGTFATNVMGTAHLLEALRASDSVRVVVIVTTDKVYRNV-EWCWPYREDDQLGGHDPY 158 Synechocystis s...
WP_010976067  82 SEPEIVLHMAAQPLVRESYAEPAETFDVNVMGTVRLLEAARATPSVKAVLVVTTDKVYRND-ESGRHFRESDTLGGHDPY 160 Sinorhizobium m...
1WVG_A       158 SNSKGCAELVASAFRNSFFNPAnye-qhGVGLASVRAGNVIGGGDWAKDRLIPDILRSFENNQQVIIRNPYSIRPWQHVL 236 Salmonella ente...
AAS70722     157 SSSKSCADLIAQSYYYSFLKDT------KTKIAITRAGNVIGGGDWAADRIVPDCIRAWGGNESVTIRSPLATRPWQHVL 230 Leptospira inte...
AAO76457     158 SGSKGAAELVIKCYWKSFIQVMp-----NIKLGVARAGNVIGGGDWAKDRIIVDCINAFSQNRIVEVRCPKATRPWQHVL 232 Bacteroides the...
AAP10451     161 SSSKGCCELLISSYRNSYFSVEnfs-qhKKIIASVRAGNVIGGGDWSIDRIIPDCIRALESNKNIIIRNPTAIRPWQHVL 239 Bacillus cereus...
CAI38723     158 SASKACAELVIDSMRQSFFNANdfgskhQILIASARAGNVIGGGDWSEDRLIPDIIKACIGNKIVEIRNPKSTRPWQHVL 237 Campylobacter j...
CAE19662     162 SSSKAAAEIAIESFRSSFCGNSnfq-knNLLIASVRSGNVIGGGDWSDNRIIPDLIRSIISEKIITIRNPDSVRPWQHVL 240 Prochlorococcus...
P26397       158 SNSKGCAELVASAFRNSFFNPAnye-qhGVGLASVRAGNVIGGGDWAKDRLIPDILRSFENNQQVIIRNPYSIRPWQHVL 236 Salmonella ente...
AAS42304     159 SASKACAEIVATSYQKSFFRt------nTQKLASVRAGNVIGGGDWAEDRLFPDVIRAYLQDATLTIRNKNAIHPWQHVL 232 Bacillus cereus...
BAD79631     164 SASKAAMELAVASWRSSFCGDAahq-tpYLAIATARAGNVIGGGDWAVDRIVPDAVRSLSAGAAIAVRNSHSTRPWQHVL 242 Synechococcus e...
WP_011137439 157 SSSKACAELVCAAYRRSYPG--------MAPIATARAGNVIGGGDWSANRLVPDLLQAFSENRSLAIRSPDAVRPWQHVL 228 Chromobacterium...
WP_011088720 161 SSSKACAELVTAAYRSSFFSgt-----hRIGFASARAGNVIGGGDWAQDRLVPDVIAAIRNGQPVPVRNPDAVRPWQHVL 235 Bradyrhizobium ...
WP_010871532 159 SASKAACEIVVASYRDAFLREQ------GVAVASARAGNVIGGGDWSEDRLIPDVVRALDAKTMVIIRRPQAIRPWQHVL 232 Synechocystis s...
WP_010976067 161 SGSKAACELAVATWRSAYLKER------GIRVATARGGNVIGGGDFSDDRLVPDVVRAALSGTRLNIRSPLATRPWQHVL 234 Sinorhizobium m...
1WVG_A       237 EPLSGYIVVAQRLYTEGAKFSE-------GWNFGPRDED-AKTVEFIVDKMVTLWGddaSWLLDGE-NhPHEAHYLKLDC 307 Salmonella ente...
AAS70722     231 EPLSGYLLLGEKLYIGQEGLVGe------AFNFGPDASVnQTVLELLNAIAERWPGvqwEIPKGYEgG-GREANLLKLSC 303 Leptospira inte...
AAO76457     233 EPLSGYLVLGQYLFEDKVK-NGe------PFNFGPRAEQtKTVFELVQDLSELWGLdkdHVAKLTDnIpFKEASLLKLNC 305 Bacteroides the...
AAP10451     240 EPLSGYLLLTEKIINNGILYSG-------AWNFGPSLSNiVSVEKLVTSLLDIWGCgdwTAEN-IDpInFHEANLLNLDI 311 Bacillus cereus...
CAI38723     238 EPLYGYLLLGTKLLQGHTEFAT-------SFNFGPEVSGnLRVEEVLKIAKNFWdk--iSYQHKIDlNaPHEANLLMLDT 308 Campylobacter j...
CAE19662     241 DPLSGYLKLAEKLFENNINLAS-------SFNFGPNLDSnKKVLDLVHKAEEFWPVswkIIESk---QdFHEARFLGLNT 310 Prochlorococcus...
P26397       237 EPLSGYIVVAQRLYTEGAKFSE-------GWNFGPRD-EdAKTVEFIVDKMVTLWGddaSWLLDGE-NhPHEAHYLKLDC 307 Salmonella ente...
AAS42304     233 DPLHGYILLAEKLWTD-AEYAE-------AWNFGPLN-EpNRTVHDVIQSVIKLWNkqlTITSPST-NtPYESPVLTLDS 302 Bacillus cereus...
BAD79631     243 EPLGGYLLLAQRLLGHQQSAEKtvnpfarAFNFGPAIESnRSVKELITTVLQHWPG---QWFDQSDpTaPHEAGLLHLVS 319 Synechococcus e...
WP_011137439 229 ESLAGYLRLAERLAQGQDDAAS-------AWNFGP-ADDsNRPVSWIADTLARQWGgdaRWHRDGG-DhPHEAQTLRLDS 299 Chromobacterium...
WP_011088720 236 EPLSGYILLAEHLWRDPAAFSS-------EWNFGPDA-DsVRTVRWLVDRLALLWGvpsQQMPQPG-QhPHEARLLSLDS 306 Bradyrhizobium ...
WP_010871532 233 EPLAGYLLLAQKLWHSP-ELAG-------AYNLGPETKDaATVRQILEFASRIEPGlqvEYGD--GnEgPHEAGWLSLEI 302 Synechocystis s...
WP_010976067 235 DCLNGYFLFAEALFKGESDVD--------ALNFGPSPSEqAIPVRDVANAVQAAMGldpEWDDVSAlEqPREMRTLGLDP 306 Sinorhizobium m...
1WVG_A       308 SKANMQLGWHPRWGLTETLSRIVKWHKa-WIRGE-DMLICSKREISDYM 354 Salmonella enterica subsp. enterica serovar Ty...
AAS70722     304 DKALYHLKWKPVLGFSETVDFTVNWYRn-WIEKKeNVYDFTLSQIRIYC 351 Leptospira interrogans serovar Copenhageni str...
AAO76457     306 DKALAYLNWHSTLHYEQCVRFIADWYKtfYLQQNiDMYQLTVAQIKEYL 354 Bacteroides thetaiotaomicron VPI-5482
AAP10451     312 SKAKFNLNWQPKWSLQQTLENTIEWYKhyNSYTSsEMRNLCISQIKQYC 360 Bacillus cereus ATCC 14579
CAI38723     309 SKAKKMLSWNSLLTAEESIKMTIEWYKsfYNKKE----LISVKQLKKII 353 Campylobacter jejuni
CAE19662     311 DKAKDLINWEPRWDFDESVKRTFLWYKnyYLFSS-ETEKYCKEDLEHFL 358 Prochlorococcus marinus subsp. pastoris str. C...
P26397       308 SKANMQLGWHPRWGLTETLGRIVKWHKa-WIRGE-DMLICSKREISDYM 354 Salmonella enterica subsp. enterica serovar Ty...
AAS42304     303 TKAVTKLGWTPKLSTDKAITWTVDWYKk-YASGE-NIESFTRQQIDAFK 349 Bacillus cereus ATCC 10987
BAD79631     320 DQARQLLGWQPRWDFETTVSRTIHWYRpvMMTGG-SALEACLEDLATYG 367 Synechococcus elongatus PCC 6301
WP_011137439 300 AKSRQRLGWSPRWSLEQALSATLDWHRa-WLRGE-DMQAFTLKQISAYT 346 Chromobacterium violaceum
WP_011088720 307 SKARAHLGWAPRWGLDRAASAVVEWYKa-FEQGA-AVRPVMVDQIDAFM 353 Bradyrhizobium diazoefficiens
WP_010871532 303 AKARTLLGYRPSWGVEEAVRRTMIWYRs-QRQGE-SPLTLCQTEIEEYE 349 Synechocystis sp. PCC 6803
WP_010976067 307 ALAGETLAWRPRLAQSQAIEWTARWYDg-WRRGE-AARQLTLDQIEAFT 353 Sinorhizobium meliloti
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