4XYW


Conserved Protein Domain Family
GT4_CapM-like
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cd03808: GT4_CapM-like 
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capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Links
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Statistics
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PSSM-Id: 340837
Aligned: 55 rows
Threshold Bit Score: 237.493
Created: 6-Dec-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #                                               
4XYW_A         3 NVGFIVTks--eIGGAQTWVNEISNl---iKEECNIFLITSEEGW------LTHKDVFAGVFVIPg----IKKYFDFLTL 67  Escherichia coli
ABR10704       4 KLLHFSEv---gGGVDRYIKLYLKYs---dKEHFKNIVVGSDQLNrq--tyEQEYNIKFYHIDIYr---sLSPIKLLRAI 72  Streptococcus p...
AAO37690       3 KILHIHLss-kiSGAQRVSLDEMKTl---sNHYSQYMVCSKEGDFtq---eADRIGVKTYVIETLvr--eISPLKDFYSL 73  Escherichia coli
YP_143909      2 RLLYLITra-epGGAQVHLLELLRGf----RDRAELHLGVGEDQDgflveeARALGVRVHLLRHLvq--pVRPVKDFLGL 74  Thermus thermop...
AAD50490       3 KIAHIQLl----PMLSGVQKVTLQElmilnDNEYTKYLICKEEGElt--eeCKRLGIKTHVVKDLtr--eINAVKDIIAL 74  Escherichia coli
NP_875074     16 RINLIVTrsdtvGGVHTHILNLIKTl---eSFNCSVHVITGNSKKalfikrLDKLSIKYTINPYLvh--pISIFNDVLAI 90  Prochlorococcus...
YP_498691      2 KIIYCITka-dnGGAQTHLIQLANHf----CVHNDVYVIVGNHGPmi---eQLDARVNVIIIEHLvg--pIDFKQDILAV 71  Staphylococcus
YP_004889103   2 KLVYVITqg-gwGGAQAHVFDLISSa---vQLNNQIWIICGSTGRlt--deIKHIFPKVHVIVLDdlcreVSFSHDLKAV 75  Lactobacillus p...
YP_004889853   2 KIVYIITqa-twGGAQAHLYSLIKAq---vMRGNAVALVYGVEGRlsasvaKEFQDVQVVRVASLvh--pIAPLSDLKAI 75  Lactobacillus
YP_536448      9 KLLFIVEam--gGGIFTYITNLTNEl----VKKYDVYVAYSVRKEtpk-dfKKSFNVNVKLIKVEnfvrsINILQDLKAY 81  Lactobacillus s...

Feature 1                                                                                        
4XYW_A        68 FKLRKILKENNISTLIASSANAGVYARLVRl---lVDFKCIYVSHGWSCLYNGGR---LKSIFCIVEKYLSLLtdVIWCV 141 Escherichia coli
ABR10704      73 KQFRKILYLERPDIVYLHSTFAGVVGRLASm---gLSCKVVYNPHGWSFKMDVSKi--KQFVYKNIEKFLSYLtdKYILI 147 Streptococcus p...
AAO37690      74 IKLYKFIKQEKFDIIHTHSSKSGFLGRLAAkl--aGTKQIIHTVHGFAFPSTSNRv--VKLIYFLMEYFASLCssVIIVM 149 Escherichia coli
YP_143909     75 FEVMALIRKVRPHLLHAHSSKAGFLGRLAG-----RVLGVKSVFTAHGWAFTDGVpegRKRLALAMERLAGRLgdLVLAV 149 Thermus thermop...
AAD50490      75 YKIYKFLKANDIDIVHTHFAKTGFLGRVAAkl--aGIPLIVHTVHGFPFDSAKNKy--IAFFYKVLEFISARFadIIICL 150 Escherichia coli
NP_875074     91 LWLTIFTIRSPKSILWSHSSKAGIISRIAAf---iSMTPSIHTVHGWSFVAPKRKl--TKTIYLILERILSVItkKFIVV 165 Prochlorococcus...
YP_498691     72 KVLAQLFSKIKPDVIHLHSSKAGTVGRIAKfisksKDTRIVFTAHGWAFTEGVKPa--KKFLYLVIEKLMSLItdSIICV 149 Staphylococcus
YP_004889103  76 MYLRRIFRRVKPDIIHLHSAKAGIIGRIAAy----HISPVIYTVHGWAFTTGVSKk--RALLAIAVERVLQPLtaRYICV 149 Lactobacillus p...
YP_004889853  76 YTLRKLVKNWQPDIIHLHSSKAGMIGRLATi---rLPMKVIFTVHGWGFTPGVGKk--RQLLMKTIEKALSRLttAYICV 150 Lactobacillus
YP_536448     82 IEIKKIVKKVNPDIIHLHSSKAGVLGRLAFsf-fnNKYTVFYTPHGYSFLMSDTSk-vKRLVYRNIEKILGMGnaVIISC 159 Lactobacillus s...

Feature 1                                                                            ###         
4XYW_A       142 SKNDEKKAIENIgik-epKIITVSNSVPQMPRCNnk------------------------qLQYKVLFVGRLThPKRPEL 196 Escherichia coli
ABR10704     148 SKSEYEAAQSLKiplkklTLVYNGVEIDEDFNEHqinv-------------------llpiNKYVIGMIGRISeQKNPFF 208 Streptococcus p...
AAO37690     150 NENDEKIARKYFssapwtKVTLLNNAVDIKKFQKryigies-------------kseineqKKFKMVMIGRLCeQKNPLL 216 Escherichia coli
YP_143909    150 SEYDRALALRHKavp-peRIRVVHNGVPDTPFRAdp-----------------------rkEPPRLAMVARFApQKDHAL 205 Thermus thermop...
AAD50490     151 HDGDKETCKKLLhvp-esKVLVLPNGIAFTEFFRlsecdkkka----------rtilgipeSSLVFTMVGRLWeQKNPLL 219 Escherichia coli
NP_875074    166 SEFDYNLALKKGf----pYRKIDLIHNSVDRKSYrnrai------------------nakdSKVRFIMVARFDkQKDHLT 223 Prochlorococcus...
YP_498691    150 SDFDKQLALKYRfnrlklTTIHNGIADVPAVKQTlksqshnnigevvgmlpnkqdlqinapTKHQFVMIARFAyPKLPQN 229 Staphylococcus
YP_004889103 150 SKFDYNLGIKKGlmnkrhPGTVIHNGVRKEVFQHsl-----------------------ikKHPTIVMAARFDvPKRQDL 206 Lactobacillus p...
YP_004889853 151 SQFDYDLGVQSGvitsahPARVIHNGVTALTGANkat----------------------ssEVFVLSMAARFDtPKRQDI 208 Lactobacillus
YP_536448    160 SPGEDKESQKIAk-----YTEHVNNGINMKEITNvvgdy-----------------kksnsNKVKVATLGRISyQKNPAL 217 Lactobacillus s...

Feature 1                                                            #                     #     
4XYW_A       197 LANVISKK------PQYSLHIVGGGERLESLk---kQFSECENIHFLG-EVNNFYNYHEYDLFSLISDSEGLPMSGLEAH 266 Escherichia coli
ABR10704     209 FVEFAKKLse--iySNLYFVIVGDGELRGRTeelieEYGLRSSFFITGwVDNPEDYLAQFNQAVLFSKWEGFGLAVAEYM 286 Streptococcus p...
AAO37690     217 IINALKILgd---hYYVDFVGDGPLRSDLESqi--aKRGLEKRVRLLGwCSSVEEIIFKYDLFLLPSKWEGMPLAILEAM 291 Escherichia coli
YP_143909    206 LLKALSGLk----eLPWSLDLVGEGPLLPQAkalaeALGLGERVRFLGkRLDVDRVLAEAQVFVLATNWEGLPLSVLEAM 281 Thermus thermop...
AAD50490     220 LINAAKEVineypsDDIIFLLIGDGFLRKEIeriaeREIYHNKIVLLGwRKDIPDILSCSDVFVLPSRWEGMPLAILEAQ 299 Escherichia coli
NP_875074    224 VLNAFSLLsh---yDNWELYFIGDGPLYEKIyqyasTLNIADKIIFGGhVSNVEKYYSLCNVFILSSHWEGFPMTSIEAM 300 Prochlorococcus...
YP_498691    230 LIAAIEILklh-nsNHAHFTFIGDGPTLNDCqqqvvQAGLENDVTFLGnVINASHLLSQYDTFILISKHEGLPISIIEAM 308 Staphylococcus
YP_004889103 207 LIRALEKIs----dKSLHLILLGDGPKLLACqelanNLNIENRVHFLGsVTNVREYYADADIVMLISDYEALPISIIEGL 282 Lactobacillus p...
YP_004889853 209 LIQALTYLpe---nLPIVCHFLGDGPSIEACktlthQLNLDGKVNFYGvVDNVQKYYSQSDVGVLISDYEALPISLVEAL 285 Lactobacillus
YP_536448    218 FNRIAENM------PEKEFIWIGNGELKEEI-----TSPNVRITGWLD-RNAALRKLNEADIFILTSRWEGLPMALLEAM 285 Lactobacillus s...

Feature 1                                                                                        
4XYW_A       267 TaAIPLLLSDVGGCFELIE-GNGLLVENTEd-------dIGYKLDKIF--DDYENYREQAIRASGKfvIENYASAYKSII 336 Escherichia coli
ABR10704     287 KhKKPILITNVDGMSELVIdGESGFKVPLYn--------LEVTVDRSRsiIENRELANELGSAAFQrvRSTFEIKEKVSE 358 Streptococcus p...
AAO37690     292 AsKVPVLCSNIDANAYLIN-KTSGFLFNNDd--------AKDLAKNIKyiFDNVDVRRKVAEDAYLavVKDFELSERTKI 362 Escherichia coli
YP_143909    282 RaGLPVVATGMGGVGEAVVeGKTGFLVGRGd--------EEALRARLRtlLLSPELRARLGEAGRRryEEAFTLDGMLAR 353 Thermus thermop...
AAD50490     300 AtGLPCIVSDIPGNNNLVKdGVNGYLFESGs--------VTQLKDAILr-MRVIEKRHEMGINAYDyvSQKHCIHKRIDN 370 Escherichia coli
NP_875074    301 SySLPLIISDVGGSKEVVIdDYNGYIFNSKd--------YQTLSKYISkfLEDPNICISMGKASLRifENAFSDRIASDK 372 Prochlorococcus...
YP_498691    309 AtGLPVIASHVGGISELVA-DNGICMMNNQ---------PETIAKVLEk-YLIDSDYIKMSNQSRKryLECFTEEKMIKE 377 Staphylococcus
YP_004889103 283 AsAKPIIASNVGGINELIQ-NNGFLVANSVn--------EIVQCVQLL--LENRNLRNDMGQKSFEmfQNEYTERKMLSK 351 Lactobacillus p...
YP_004889853 286 AqGLPIIASNVGGIQELID-HNGFLVTNDA---------RQIAEKILT--LYQSKKIAEVKTNSYQmyQRHYTEHEMLEQ 353 Lactobacillus
YP_536448    286 YmGKLCIVSDTIGNNDVIKnNVNGFICDSIedyinainvSKEKKKELI--EHAIDDVKKEYNTITM--ARKYSEIYDRLK 361 Lactobacillus s...

Feature 1          
4XYW_A       337 LG 338 Escherichia coli
ABR10704     359 LE 360 Streptococcus pneumoniae
AAO37690     363 LE 364 Escherichia coli
YP_143909    354 VW 355 Thermus thermophilus HB8
AAD50490     371 ID 372 Escherichia coli
NP_875074    373 IK 374 Prochlorococcus marinus subsp. marinus str. CCMP1375
YP_498691    378 VE 379 Staphylococcus
YP_004889103 352 TF 353 Lactobacillus plantarum
YP_004889853 354 TQ 355 Lactobacillus
YP_536448    362 YK 363 Lactobacillus salivarius

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