3ZL8


Conserved Protein Domain Family
murF
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TIGR01143: murF 
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UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Links
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Statistics
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PSSM-Id: 273468
Aligned: 20 rows
Threshold Bit Score: 426.682
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3ZL8_A        11 LNSKEVREGDVFVAVKGKRFDGHDFIDEALRNGAYAIIAER-----------KTVNSDRIFLVESSVDTLAKLAREKLGN 79  Thermotoga mari...
WP_010229498  30 IDSRLVLPGDVFFALPGNRTTGHLFLKQAAQSGAVAAVVASdy--------rGPDYGLQLLHVADPREALRAAGRTQGAL 101 Chlamydia murid...
WP_010725334  30 IDSRFVLPGDVFFALPGNRTSGHLFLKQAAQSGAVAAVVASdy--------hGPSYGLQLLRVADPREALRAAGRTQGAL 101 Chlamydia trach...
WP_010880501  29 IDSRTIKQGEVFIPLKGQKFDAHNFIPDAFKKGAVGVISERe---------vDVPPGKFLIKVRSTLESLREIAKFKREN 99  Aquifex aeolicus
WP_004597930  27 FNSKDVKKGDLFIALQGNR-DGHDYIQDAIDKGATAVIVSKq---------vEINDKDKIILVNNSFEALQKMALYKREN 96  Rickettsia prow...
WP_003234322  56 TDTRKLEQHQLFIPLKGERFDGHSFVEQAFEAGVAAVLWDRsv--------pNPPENHAVILVDDTLTALQQLAKAYLQE 127 Bacillus subtilis
WP_010881834  31 FDSRAVVPRDLFIPLRGAHVDGHTFVEEALQKGAVATLIDQryphageyvawCTRFGAACIAVHDTLRALQDLASFYCKK 110 Treponema pallidum
WP_010883534  31 IDSQQVQPGDLFFALPGNATDGHQFLKHAATAGAVAAVVSHdy--------qGDSFGLELIRVDDTKSALQEAGSNQCNL 102 Chlamydia pneum...
WP_004082934  11 LNSKEVREGDVFVAVKGKRFDGHDFIDEALRNGAYAIIAER-----------KTVNSDRIFLVESSVDTLAKLAREKLGN 79  Thermotoga mari...
WP_010887414  25 WDSREAGPDTAFVALPGEKMHGNRFVERALAAGAPFVLTDLd--------------vPRAVRVDDARGALFAWARSERAK 90  Deinococcus rad...

3ZL8_A        80 FSGTV-VGVTGSSGKTTTKEILYNLLKNKRSVFKTPGNMNTEYGLPLSILNDYKGEEILVLEMAASRPGDIAHLCKIAPP 158 Thermotoga mari...
WP_010229498 102 FHGEV-IGITGSVGKTTTKSFTQQLLSPFYKVFASPKSYNSQLTLPLSILTADGDEDFLVLEMGVSEPNNMKDLLDVIEP 180 Chlamydia murid...
WP_010725334 102 FYGEV-IGITGSVGKTTTKNFANQLLSSVYKVFMSPKSYNSQLTLPLSVLMADGDEDFLLLEMGVSEPNNMKNLLEIIEP 180 Chlamydia trach...
WP_010880501 100 FKGKV-IGVAGSAGKTTTKELLSHLLSIKGKVYKSPGNLNSQVGLPLAVANASLETDFWVLEHGASKRGEIKNLIEITKP 178 Aquifex aeolicus
WP_004597930  97 SKAKF-IAITGSVGKTSTKEALKILLQHDFIVFASRGNFNNYLGLLINLASMADDTEYAIFELGMNHQGEISELVQILKP 175 Rickettsia prow...
WP_003234322 128 LGTRV-IGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANP 206 Bacillus subtilis
WP_010881834 111 FPALIrIGITGSSGKTTVKEMARAVFSERYRVVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGEMRTLAQILVP 190 Treponema pallidum
WP_010883534 103 FQGTL-VGITGSVGKTTTKEFSKTILSSIYKTHASPKSYNSQLTVPLSLLMAEGDEDVMILEMGVSEPGNMQDLLRIVQP 181 Chlamydia pneum...
WP_004082934  80 FSGTV-VGVTGSSGKTTTKEILYNLLKNKRSVFKTPGNMNTEYGLPLSILNDYKGEEILVLEMAASRPGDIAHLCKIAPP 158 Thermotoga mari...
WP_010887414  91 NPL-V-VGITGSAGKTTAKSYAAAALDAHFMPV-----FNTMPAIACFLVQYGASQKPLVVEMGIDHIGEMAELMDLVRP 163 Deinococcus rad...

3ZL8_A       159 DVAVLLNVGSAHLEFF--GTRERIMETKMEIIKHSKENAIAVTLFDDP---DLRKEVPrY---RNTLFFGKEG-GDSVLK 229 Thermotoga mari...
WP_010229498 181 SIGVITHIDVQHAMNFvdKGAQGIAEEKSLLLER---CGIHLLPRDSSwfnFFMKKNA-A---ADQFSFSMNN----ETA 249 Chlamydia murid...
WP_010725334 181 TIGVITHIDVQHAVHFldKGAQGIVEEKSLLLER---CGLQLIPKDSSwfqFFAKKNS-A---ADRFSFSMSN----ETA 249 Chlamydia trach...
WP_010880501 179 HVRLITTLGEEHLEGF--GSLEGVIWGNAEMFCRISDNFYAVIPGKf---lDTLFFLP------KKISFG-ER-GELQAQ 245 Aquifex aeolicus
WP_004597930 176 NIAMINNISEAHLEFF--HSLEEIAEAKCEIFKNFSKNDIAIINASNNcynKILSILK-NlsiTNIYSFGHSS-KA-SAK 250 Rickettsia prow...
WP_003234322 207 DAAVITNIGESHMQDL--GSREGIAEAKLEIINGLKEDGVLIYIGDEPllqNAYSCQ--------TKTYGTGThNDYQLQ 276 Bacillus subtilis
WP_010881834 191 HYAIITNVGCAHVGIL--GTQQAIAEEKKEIFSQFTEHSVGFVPDDAYr--VFLSNIP-Y---GRVVVYDQGG-RGLATE 261 Treponema pallidum
WP_010883534 182 EIAVITHINDQHAMHFp-QGIQEILKEKSYILQKSK---LQLLPKDSPyylDLRSCSP-T---AEKFSFSFND----PLA 249 Chlamydia pneum...
WP_004082934 159 DVAVLLNVGSAHLEFF--GTRERIMETKMEIIKHSKENAIAVTLFDDP---DLRKEVP-Ry--RNTLFFGKEG-GDSVLK 229 Thermotoga mari...
WP_010887414 164 DVGVVTTIGPAHLEQF--GMVETIAHEKGQILTARR----ALVGSQAAaffPKAQFPH-------VDSYGFGD-VTFRGE 229 Deinococcus rad...

3ZL8_A       230 D-WWYYEGs-TIAEFEAFDSLFTVKLsG-Y-WNGG-QLLNIAASLCVMRTLGETVDIFD--LASLKTVPGRFN-VREKKG 301 Thermotoga mari...
WP_010229498 250 DfYYRAIHs-EGVLISAPDG--DIEL-PvV-FPYTpAYMNFIIAVALAWLTNVPMDRLEqaSQSLFLPSMRFE-QQEHNG 323 Chlamydia murid...
WP_010725334 250 DfYYRAIHs-EGVLISAPDG--DIEL-PaV-FPYSpAYMNFIIAVALAWITNVPMDRLEqvSQSLFLPAMRFE-QQEHNG 323 Chlamydia trach...
WP_010880501 246 NvEVSEKG----VSFEVEGEKFFISV-P-S-LG---LVENILACFCVLKVLGFTLKEFKeaLKEFSPVEGRMK-VFNLKN 314 Aquifex aeolicus
WP_004597930 251 LiLYKTLGeqVHLQYYINNKFIDITI-P-F-IPRH-FANNYTGVLLIIDILGKDIEISAkyLADIALTKGRGK-IINIQN 325 Rickettsia prow...
WP_003234322 277 DvSQSEEG--THFTIKGIENTFFI---P-I-LGKH-NVMNAMAAIAAGAYFGIAPEDAAkgLSGLKVTGMRLElIKTDSG 348 Bacillus subtilis
WP_010881834 262 ViDEGLRGs----RVLYQGRWIRVPL-P----GVH-NAKNALAVIALAAQVGLPAEEIQrgMERVKPPFGR-S-HVVCAS 329 Treponema pallidum
WP_010883534 250 DfCYKAISg-DSVVIQTPEE--NYCL-P-IaFSYKpAYTNLLIAVALSWILEVPEEGVIrsLPELKLPPMRFE-HSMRNG 323 Chlamydia pneum...
WP_004082934 230 D-WWYYEGs-TIAEFEAFDSLFTVKL-SgY-WNGG-QLLNIAASLCVMRTLGETVDIFD--LASLKTVPGRFN-VREKKG 301 Thermotoga mari...
WP_010887414 230 GlELSPQA--ARFRFGGMG----VIL-P-L-ASRV-QAEAAVLGMVLAREAGIALADAAvrMSAVEVPGGRYR--LHPGR 297 Deinococcus rad...

3ZL8_A       302 VLIVDDTYNASPEAFQTSIEALLRFP-----G-KKFAVVGAMKELGERSKEFHEELGERLNV-LDGVYVFLSEPE-A--- 370 Thermotoga mari...
WP_010229498 324 IRIINDAYNASPDAMLAALDAVPIPSe---gG-KTVFILGHMAELGRYSDECHIAVARKAVT-KA-HVVFFVGEK-Wspv 396 Chlamydia murid...
WP_010725334 324 IRVINDAYNASPDAMLAALDAVPVPPe---gG-KIIFILGHMAELGRYSDECHIAAARKAVT-KA-HIIFFVGEK-Wfpv 396 Chlamydia trach...
WP_010880501 315 FILIDDTYNANPVSLRNAIKSVGAFK-----R-DKVFILGDMLELGEHSKELHEEVGRLLNTvKGIRLAIFYGDE-M--- 384 Aquifex aeolicus
WP_004597930 326 SRVICDYYNASPQSMKAALEYLKQVP-----AdNKTSIIGEMLELGWNSQRLHEELVPYILD-AGCTKVYLVGAY-T--- 395 Rickettsia prow...
WP_003234322 349 LSIINDAYNASPTSMKAAIQLTESLEg---yG-KKMLVLGDMLELGDLEETFHKECGAVISP-DKIDRVFTYGKLgA--- 420 Bacillus subtilis
WP_010881834 330 LTFLLDCYNANPDSMAAALHLCAHIS-----AvSKVYVLGDMGELGVTAAEAHYRVCVLAAA-SDARAVYVFGPE-Fc-r 401 Treponema pallidum
WP_010883534 324 MQVINDAYNACPEAMIAALDALPLPSd---gG-KIILILGHMAELGRYSEEGHALVAEKAAS-RG-DMIFFIGEK-Wipv 396 Chlamydia pneum...
WP_004082934 302 VLIVDDTYNASPEAFQTSIEALLRFP-----G-KKFAVVGAMKELGERSKEFHEELGERLNV-LDGVYVFLSEPE-A--- 370 Thermotoga mari...
WP_010887414 298 FTVIDDAYNASPVAVRAALDALHALKpegevG-RRISVLGRMLELGPTERELHAEVGSYARE-QA-DLTYGVGEF-A--- 370 Deinococcus rad...

3ZL8_A       371 EWIKS--KKi----I--LKSD-DPEKIAKDLA--TRVKkgDVVLFKASR------------AVRIERVLEMF 419 Thermotoga maritima
WP_010229498 397 REVVSdaNCq----I--EFYG-SVSEIMHVVK--SLVRrgDVVLLKGSR------------SLELETLLPCF 447 Chlamydia muridarum
WP_010725334 397 RDIVRdaDCq----I--GFYS-AVSEIMDAVK--ALVQqgDVVLLKGSR------------SLELETLLPCF 447 Chlamydia trachomatis
WP_010880501 385 KYAYDsfNKs----K--KFYAkTKEEMLQFIEenLKEFegCAVLIKGSR------------GMKLEEVVDFL 438 Aquifex aeolicus
WP_004597930 396 KYIYDllPNk----IskKFFK-NVEELITHIT--DLFEysELILIKGSR------------GVKLDKIVDYY 448 Rickettsia prowazekii
WP_003234322 421 FIAEGalKHfekdrV--SHYT-EKKDLLQAVK--ENASkgDLILFKASR------------GMKLEEIVKDL 475 Bacillus subtilis
WP_010881834 402 AVRKVswGRkr-vyA--FALE-ELSALQETLD--AQLRrgDFVLVKGSR------------SVALERLEPLL 455 Treponema pallidum
WP_010883534 397 QSVLKsySCe----V--SFFS-SAQDVKDILK--QVARygDVILLKGSR------------ALALESLLACF 447 Chlamydia pneumoniae
WP_004082934 371 EWIKS--KKi----I--LKSD-DPEKIAKDLA--TRVKkgDVVLFKASR------------AVRIERVLEMF 419 Thermotoga maritima
WP_010887414 371 QELg----------E--RAFA-TVPELLADLL--NEVRdgDIVLVKASRgisltpeqravtGVGLDVVVEAL 427 Deinococcus radiodurans
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