Conserved Protein Domain Family
ELO
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pfam01151: ELO (this model, PSSM-Id:395916 is obsolete and has been replaced by 460083)
GNS1/SUR4 family
Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.
Links
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Statistics
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PSSM-Id: 395916
Aligned: 144 rows
Threshold Bit Score: 105.806
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0V0L4        55 LAYKVPLAISTVYAITV-TYFNWYNR----QHanKPWris----------ktrPFFAFVIFHNVFLAVYSAITCVAMVra 119 Parastagonospor...
CAP33333      13 VSFIPIHLLGILYVFIAfNFRPSHNS----DR---SY-----------------LKEWYYFNCIFQLVLGLLMIPEILi- 67  Caenorhabditis ...
XP_002633947  64 EHFGLFVQMTIAYVIVI-FSIKRCMR----DR--EPF----------------KLTNALRFWNFFLSVFSIYGSWAMFp- 119 Caenorhabditis ...
Q20300        21 GLEGFSAKLAVGYIATI-FGLKYYMK----DR--KAF----------------DLSTPLNIWNGILSTFSLLGFLFTFp- 76  Caenorhabditis ...
XP_002633945  42 DHFDVTIQASILYMVVV-FGTKWFMR----NR--QPF----------------QLTVPLNIWNFILAAFSIAGAIKMTp- 97  Caenorhabditis ...
XP_002633891  26 QTQWPAFWISMAYVVVI-FGIKAAMV----NR--KPF----------------DLTGPLNYWNAALAIFSTAGSVFTSf- 81  Caenorhabditis ...
XP_002632413  30 TFVPLSYKIMVGYLITI-YFGQKLMA----HR--KPF----------------DLQNTLALWNFGFSLFSGIAAYKLIp- 85  Caenorhabditis ...
XP_001563354  22 KNIDLVGYIASFYLVMV-GKGDRILSwwnaRK--PLApnaaakqngankemvaALKSCYTAASMYHLVVSIAGAAISCml 98  Leishmania braz...
CAM37541      30 DYFDVLFYSGVLYILIV-FLGPKAME----NR--EPF----------------KLKYFIAMWNLTLSLFSFCGTIAVGt- 85  Leishmania braz...
CAM66633      47 ASPHIPLLIVVGYFLLV-HAGPRVFSrllgGK--PVP----------------GLAPIVAIWNLFFSIASTIGFCYCAp- 106 Leishmania infa...

Q0V0L4       120 lktsfphYSDPNsv--------------------------vgTVDALCkingprglgdavtynsttntwasknsnvlvds 173 Parastagonospor...
CAP33333      68 -------SLFSG------------------------------WHYSVC-------------------------------- 78  Caenorhabditis ...
XP_002633947 120 ------fMVEQIrr--------------------------fgLYGCGC-------------------------------- 135 Caenorhabditis ...
Q20300        77 ------tLLSVIrk--------------------------dgFSHTYS-------------------------------- 92  Caenorhabditis ...
XP_002633945  98 ------eFFGTIan--------------------------kgLVASYC-------------------------------- 113 Caenorhabditis ...
XP_002633891  82 ------gLLHEFvt--------------------------rgFFESYI-------------------------------- 97  Caenorhabditis ...
XP_002632413  86 ------eLVSVFmk--------------------------dgFVASYC-------------------------------- 101 Caenorhabditis ...
XP_001563354  99 vpamaqsLLANS------------------------------FFEVMC-------------------------------- 116 Leishmania braz...
CAM37541      86 ------lLMYMLed--------------------------rgMYETTC-------------------------------- 101 Leishmania braz...
CAM66633     107 ------fLFRVLtmtnrelpglapkkdrttgewdqhphvrggLFTSLC-------------------------------- 148 Leishmania infa...

Q0V0L4       174 ttglpdPSDVGRIWNE-GLAFWGwwFyLSKFYEVLDTAIILAK----------GK---RSTTLQKYHHAGAMLSMWAGMR 239 Parastagonospor...
CAP33333      79 --------QAGSLYTGfLSGTVVfiWtITKIVDLFETLLLLYD----------AR---RPLTIHIIHHFLSLSYAFTFYS 137 Caenorhabditis ...
XP_002633947 136 --------EALSTLPS-QAEYWLflTvLSKALEFVDTFFLVLR----------KK---PLIFLHWYHHVATFLFFCVTYP 193 Caenorhabditis ...
Q20300        93 -------HVSELYTDS-TSGYWIflWvISKIPELLDTVFIVLR----------KR---PLIFMHWYHHALTGYYALVCYH 151 Caenorhabditis ...
XP_002633945 114 --------KVFDFTKG-ENGYWVwlFmASKLFELVDTVFLVLR----------KR---PLMFLHWYHHILTMIYAWYSHP 171 Caenorhabditis ...
XP_002633891  98 --------HIGDFYNG-FSGFFTwlFvLSKVAEFGDTLFIVLR----------KK---PLMFLHWYHHVLTMNYAFMSFE 155 Caenorhabditis ...
XP_002632413 102 -------QNETYYTDP-STGFWGwaFvMSKAPELGDTMFLVLR----------KK---PVIFMHWYHHALTFVYAVVTYS 160 Caenorhabditis ...
XP_001563354 117 ------LWDDTRIYKG-YVAFALsaAvMVKVVEQLDTFFLILRdyivaspaqkEKqvrRVQPSHWWFQGLIALYFWHTYS 189 Leishmania braz...
CAM37541     102 -------QLDRSLYEG-ELAFWIfaFmLSKIPEMIDTVFLVLT----------KK---PIIFLHWYHHLTVMIFCWYAGY 160 Leishmania braz...
CAM66633     149 ------YWNRNIFEDG-ATAFWVltFnLSKIVELMDTVFLLLR----------HK---PVPFIHWYHHASVMLFCWHAHV 208 Leishmania infa...

Q0V0L4       240 FM-APPIWMFVLVNSGIHAMMYTYYTVS-----ALGyrVPNvvKRTLTTLQITQFLVGSaYAAIHLFVSytipvtvahqi 313 Parastagonospor...
CAP33333     138 QN-FAIHRWIVFFNLTAHVFLYAYls------gYKIlnRWTpcWVAVCSSQMLQLILPF-IATLFAAAKmtr-------- 201 Caenorhabditis ...
XP_002633947 194 TP-SSQIRVGAIVNLFVHAFMYPYYFIRsm--nIKl-pAKI--SMAVTVLQLTQFVCFI-YGCTLMYYSlat-------- 258 Caenorhabditis ...
Q20300       152 ED-AVHMVWVVWMNYIIHAFMYGYYLLKsl--kVPi-pPSV--AQAITTSQMVQFAVAI-FAQVHVSYKhyv-------- 216 Caenorhabditis ...
XP_002633945 172 LTpGFNRYGI-YLNFVVHAFMYSYYFLRsm--kIRv-pGVI--AQAITSLQILQFIISC-AVLAHLGYLmhf-------- 236 Caenorhabditis ...
XP_002633891 156 ANlGFNTWIT-WMNFSVHSIMYGYYMLRsf--gVKv-pAWI--ARNITTMQILQFVITH-FILFHVGYLam--------- 219 Caenorhabditis ...
XP_002632413 161 EHqAWARWSL-ALNLAVHTIMYFYFAVRal--nIQt-pRPV--AKFITTIQIVQFVISC-YIFGHLVFIksan------- 226 Caenorhabditis ...
XP_001563354 190 IG-TSCFTMIATLTMVMSAARNFVYMQQdtaqaHGKsaAAVklNSAIVALDMMEWIGCSaLSVYASLMNytd-------- 260 Leishmania braz...
CAM37541     161 LIiPSGIWFA-AMNYFVHSIMYFYYFLCsl--gLRKviRPF--APFITAAQLLQMVAGT-AIVLYTFYYsyi-------- 226 Leishmania braz...
CAM66633     209 SGiSNGLGFA-VMNMLVHSIMYFYYFMCac--gQRKlvRPF--ASMVTLLQIAQMFAGM-ALILYTTRLyvt-------- 274 Leishmania infa...

Q0V0L4       314 vekvapklnsssissavssatssavaalptatgpalaflrkliyraagdeglaeniavpgeplpyyqqqqalaagqrpeh 393 Parastagonospor...
CAP33333         --------------------------------------------------------------------------------     Caenorhabditis ...
XP_002633947     --------------------------------------------------------------------------------     Caenorhabditis ...
Q20300           --------------------------------------------------------------------------------     Caenorhabditis ...
XP_002633945     --------------------------------------------------------------------------------     Caenorhabditis ...
XP_002633891     --------------------------------------------------------------------------------     Caenorhabditis ...
XP_002632413     --------------------------------------------------------------------------------     Caenorhabditis ...
XP_001563354     --------------------------------------------------------------------------------     Leishmania braz...
CAM37541         --------------------------------------------------------------------------------     Leishmania braz...
CAM66633         --------------------------------------------------------------------------------     Leishmania infa...

Q0V0L4       394 pveqlfhrpqetvnrviyrteyqsvPCidtsgQAF--AIYLNLIYLAPLTFLFMRFFF-KSY--LRRTSPN 459 Parastagonospora nodorum...
CAP33333     202 -----------------------gtQCdanalGIFtlQIGLSV-----MILLFADFYWsRLQefRRKNMKK 244 Caenorhabditis briggsae
XP_002633947 259 ----------------------nqyTCdtp-----mfALNSTFGLSLSYFVLFANFFH-KSY--LQRGGKE 299 Caenorhabditis briggsae
Q20300       217 ----------------------egvEGlay----sfrGTAIGFFMLTTYFYLWIQFYK-EHY--LKNGGKK 258 Caenorhabditis elegans
XP_002633945 237 ----------------------tnaNCdfd-----psVFKLAVFMDTTYLALFINFFL-QSY--VLRGGKD 277 Caenorhabditis briggsae
XP_002633891 220 -----------------------tgQSvds----ttgYYWFCLLMEISYVVLFGNFYY-QSY--IKGGGKK 260 Caenorhabditis briggsae
XP_002632413 227 ----------------------svpGCavs-----wnVLSIGGLMYISYLFLFAKFFY-KAY--IQKRSPT 267 Caenorhabditis briggsae
XP_001563354 261 -----------------------krGC-----MTMqaNVRMALVMYVTAVVLRLRELI-KGAegLAARESK 302 Leishmania braziliensis ...
CAM37541     227 ----------------------serGCnad-----rrTIRMGVGMYGSYFVLFATLFA-RLY--VKRSGTA 267 Leishmania braziliensis ...
CAM66633     275 ----------------------hpgGCdts-----asSLAFGTVMYLSYIILFVKLFR-DNY--VLKKRDG 315 Leishmania infantum JPCM5
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