Conserved Protein Domain Family
PTS_EIIC_2
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pfam13303: PTS_EIIC_2 (this model, PSSM-Id:404225 is obsolete and has been replaced by 433101)
Phosphotransferase system, EIIC
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.
Links
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Statistics
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PSSM-Id: 404225
Aligned: 39 rows
Threshold Bit Score: 180.837
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ripcm:ACL_0491    27 SKTLNGMTFGIFGTIVVGAIIQTLGIITGID----VLNLRVAPVLTSLLGMGIGLSIGLSLKVDGLKLIMLSVAGGIGTl 102 Acholeplasm...
Q6LQ05            28 SAAMSGLADAAIATFLVEAIHKYVMGNLLGI----GYLAEFGNLVGGMGGVAAATLVMLRVGVQPVFAMVTGLAm----- 98  Photobacter...
Q2G165             1 MRAMGALANAAIATFLVEAFNKYVGGEVFGI----KFLEELGDAAGGLGGVAAAGLTALAIGVSPVYALVIAAAc----- 71  Staphylococ...
Q8XP04            28 MKAMGALAGAACASFLVEAFHSSFFGNVLNI----EFLKKVGDANGSLGGVAAAILVPLALGVSPVYSVLIGLSc----- 98  Clostridium...
Q9A1Q9            28 aKAMGALASAACASFLVEAFQDSFFGKVLGF----QFLSEVGGANGSLSGVAAAILVAIAIGVSPGYAVLIGLSv----- 98  Streptococc...
jgi:EAT1b_0176    28 MKAMGALAGAAIASFLVEAFNAYAIGGLLPL----PLYEEVGQAAGALSGPAAAALVAIALGINPVYSLMIGLSv----- 98  Exiguobacte...
Q5FLN1            10 lNILSGVSSGVVIALVPGALVNEIMKSISDVwpaaQSVLAMTTLMQDLLAVFAGLCVSYLLKFNLIQSGSVTAAAMIASg 89  Lactobacill...
WP_012726860      15 MNVLNGLSMAILIALIPSALLGELTKAILPYfpslQFILDATTIAMRLLPAIIGLAVAMQFGRSILEAGTIAIATYVGSg 94  Exiguobacte...
cebbi:cauri_1467  34 MKVLNGISIAVVVSLVPQALLGELAKALLPLwsgaSTVIALTGLAASLLPVMIGVLVGIEFKMTPIQTAAVGIASFCGSg 113 Corynebacte...
cebbi:ckrop_0280  38 MNVLNGISVAVVVALVPQALLGELFKALLPVfpqgKEIIGMVSVASSMLPIAIGLLVAMQFKMTHIQTATVAISAVMGSg 117 Corynebacte...

ripcm:ACL_0491   103 vkidfsmpgwfdpvkVSNNPITAYFVVIGAYFAIQAIFr-KKTAYDLFFIPIVGILSAVLVTYL-ISWPIDRFMEMIYST 180 Acholeplasm...
Q6LQ05            99 --------------iHLG-ILEGFIVGYLFSFIAPLFKkyLAEGIDVILGVLILAPLARLVGFF-ISPALDLLMGTLANM 162 Photobacter...
Q2G165            72 --------------gGM-DLLPGFFAGYMIGYVMKYTEkyVPDGVDLIGSIVILAPLARLIAVL-LTPVVNSTLIRIGDI 135 Staphylococ...
Q8XP04            99 --------------sGLG-ILPGFIAGYLMSFVVKFLEekLPSGLDLIVIIVVATPLTRIIGDF-TAPVVDSTLLKIGQV 162 Clostridium...
Q9A1Q9            99 --------------sGTG-IIPGFVAGYVVSFLIKWMEknIPGGLDLISIIIVGAPLTRFLAQL-ITPVINSTLLTIGDI 162 Streptococc...
jgi:EAT1b_0176    99 --------------sGFG-ILPGFFAGYILALAGTRINryLPTGVDMIFYVIVMAPLARLVATG-VDPLVTNTLEQIGAV 162 Exiguobacte...
Q5FLN1            90 afqmkn---nqiilsGSGDVINIALTIFIAAIMVKYLTp-RLGSYTILILPLAVAVLAGGIGQL-MLPYTKLITGMIGNV 164 Lactobacill...
WP_012726860      95 avride---gafvmaGIGDVITAGVTAAIATLLVMKLAp-HLKTYTVIVMPMTIIVVAGGIGTF-LLTYISQITTYIGLL 169 Exiguobacte...
cebbi:cauri_1467 114 vatvnp--eggfflkGTGLVINSGITAAIAVGLLLFIGd-RLKNYSILLLSTIVTLVAGTIGWAvTFPIVKVFTLWLGNL 190 Corynebacte...
cebbi:ckrop_0280 118 vvkgins-deflqlkGTGLVINTGLTAAFAVIMILLIGd-RLKSYTILVLPPTVIVIAGGLGKFvTYPAVLVFTKWLGNL 195 Corynebacte...

ripcm:ACL_0491   181 IKFFMQLEPFVTSAFVALIFGILLTLPfISSAGVAIAVFSVPfgvgnalaipdpiaiAAMCAAAIGCSTQMV--GFSVQT 258 Acholeplasm...
Q6LQ05           163 ITEATSLSPLIMGFLLGGLIKMVCTSP-LSSMALTAMLGLTG---------------LPMGIAAMACVGGSFtnGYVFHT 226 Photobacter...
Q2G165           136 IQSSTNTNPIIMGIILGGIITVVGTAP-LSSMALTALLGLTG---------------VPMAIGAMAAFSSAFmnGTLFHR 199 Staphylococ...
Q8XP04           163 LIASANSNPITMGIILGGIITVVATAP-LSSMALTAMLGLTG---------------APMAIGALSVFGSSFlnFVLFQK 226 Clostridium...
Q9A1Q9           163 LTSSANSNPIIMGMILGGTIVVVATAP-LSSMALTAMLGLTG---------------IPMAIGALSVFGSSFmnGVLFYR 226 Streptococc...
jgi:EAT1b_0176   163 IELAATQNPVVMGLVLGGIVTVVSTSP-LSSMALTAMLGLTG---------------VPMAIAALALTASISmnYLLFRQ 226 Exiguobacte...
Q5FLN1           165 VAGMTDFQPLIMGMFMGVAFATLVITP-VSSVGIAMAIGVEG---------------IASGSANLGITAGAF--TLAIMS 226 Lactobacill...
WP_012726860     170 IMTMTDLQPVLMGILIAMAFSLIIVSP-ISTVGIATAISLSG---------------VAAGAANLGVVAAGF--GLAIAG 231 Exiguobacte...
cebbi:cauri_1467 191 VNGATTLQPVLMGVVLAVLFAIMIVSP-VSTVGIATAIFIDG---------------IASGTANLGAVAAGF--TLLVAG 252 Corynebacte...
cebbi:ckrop_0280 196 VVGAADLQPIVMGLILGIAFGVMMASP-ISTVGIATAIFLSG---------------IASGVANVGCCAVAF--TMMWAG 257 Corynebacte...

ripcm:ACL_0491   259 LRKNNLGSIFTVGLASSMFQFKNVMRKPI-VWAPTLIASFILAPLSYFIfdgyqwfiNLIpvGHQFSAvwaGMGTSGLVG 337 Acholeplasm...
Q6LQ05           227 LKLGKSCNTVSVML-EPLTQAHIVTRNPVpIFMSNFIGGAFAGTIAAYF--------GII--NDAPGS---AAPIPGLLA 292 Photobacter...
Q2G165           200 LKLGDRKSTIAVSI-EPLSQADIVSANPIpIYITNFFGGAIAGLIIAMS--------GLI--NDATGT---ATPIAGFLV 265 Staphylococ...
Q8XP04           227 MKFGSKKDTISVAI-EPLTQADIITANPIpIYVTNFIGGALCGIIIVLM--------GLT--NMSPGT---ATPIAGFAV 292 Clostridium...
Q9A1Q9           227 LKLGERKDNIAFAI-EPLTQADVTSANPIpIYVTNFVGGAACGVLIALM--------KLV--NDTPGT---ATPIAGFAV 292 Streptococc...
jgi:EAT1b_0176   227 LKIGTKKDQLSVAI-EPLTQADLISANPIpIYSVNFVGGAIAGLIVAMT--------GMI--NDAPGS---AAGIPGLLV 292 Exiguobacte...
Q5FLN1           227 SKVNGFGTTIAHFLGTPKIQMANVLKNPK-LFIPVSASAAIAGLVGAIF--------QIS--GTPNSA---GFGSTGLIG 292 Lactobacill...
WP_012726860     232 WQANATGTSIAHFLGSPKIQMANFVRRPI-MMLPILANAAILGALAGIL--------KIE--GTPISA---GFGVSGLIG 297 Exiguobacte...
cebbi:cauri_1467 253 WRVNGFATSILHVLGSPKVQMANMLSKPV-TFLPVICSAAVLGGVGGAL--------GIS--GTPISA---GFGISGLMG 318 Corynebacte...
cebbi:ckrop_0280 258 WKVNGPGGSLVHVVGSAKVQVANMMRRPV-ALLPAIVACGVSGIVAGIF--------RVQ--GTPISA---GFGISGLVG 323 Corynebacte...

ripcm:ACL_0491   338 ILQPL----TITNF--SLdGWLFVSSMILFPLVLVFWLDVVF-----IKLNWYTENDLIL 386 Acholeplasma laidlawii PG-8A
Q6LQ05           293 SIAFN-------PP--ST-LFMAASAAAVAGLLGGVIGVKIY-----RTFLQERVPLQQF 337 Photobacterium profundum
Q2G165           266 MFGFN-------HP--TT-IVIYGVVMAIVGALAGYLGSIVF-----KKYPIVTKQDMIN 310 Staphylococcus aureus subsp. au...
Q8XP04           293 MFAYN-------PA--FK-VLIASLACVVVSAGSGYLGYLLFknykiHTVDEIRGNDLEV 342 Clostridium perfringens
Q9A1Q9           293 MFAYN-------PV--AK-VLITALGCIIISLIVGYIGGSVF-----KNYRLVTKQELQa 337 Streptococcus pyogenes serotype M1
jgi:EAT1b_0176   293 MYGFN-------DW--QT-VTFTAVVLFILGIGFGLIGSRLF-----KNFPIVRHTEKVE 337 Exiguobacterium sp. AT1b
Q5FLN1           293 PLTAYqn-mTTGGP--IT-IIFLILLFMGMPLMLGLIMRYIFi----QKLCFVKEEDLli 344 Lactobacillus acidophilus
WP_012726860     298 PVNALhlmpGGFAL--FN-VLLVIVLFGLIPVALGIFFYRVF-----ERATLVKSDHYRL 349 Exiguobacterium sp. AT1b
cebbi:cauri_1467 319 PLAALn--yEGWGWsaGN-VMIITFVYVILPLALALLFCWLFe----KVLHLTRAEYFSL 371 Corynebacterium aurimucosum ATC...
cebbi:ckrop_0280 324 PLAALn--aDGWGWsvRN-ILVVALVYAVVPCVSAFFAVKLFd----KKLGVTNENMYAL 376 Corynebacterium kroppenstedtii ...
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