Conserved Protein Domain Family
G1PDH

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cd08175: G1PDH 
Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner
Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.
Statistics
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PSSM-Id: 341454
Aligned: 83 rows
Threshold Bit Score: 319.456
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activemetal binding
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           #                                         
B3EYN8     26 IEQMVVGREAFARLVAYLrhk--------ryeRVAIVADDHTFAAVERSLCDQLengsirytvcLVQPDENGDVIADERS 97  Geobacillus stearo...
AFS48447   33 IKNIEIRETLDGKETNLIkdlh-------snqKLLVVSDPFTHTAMGSRIFKNLk--------gNLNVDEYIWEHPSSSI 97  alpha proteobacter...
AEH50234    2 PKTIKCGCGKDHEVPDVKi-------------VWKVNSAKNIVEFFKDSLLVADkstaklvkpsEDFFVFEQSRILASME 68  Thermotoga thermarum
ABV34079    6 GKKIQCNCGKIHTIPSVNivwdrfsntyfsnkKSLFVADENTANLSNLSGKNVL----------TLTDPRRVTATVENVD 75  Thermotoga lettingae
EKE74328   40 FNHIEIGDGFADAARDMVnavm-------paqSYAVVCDADTVEVMGADIARNMq--------gKAEIIVLDHPHADEGQ 104 Celeribacter sp. L-6
EAU39692   23 YDRVVIDESLDGREAELVaamn-------lgeRVAIVADEATYAALGERVENAIar-------lKPDLIVLDHPHADVKA 88  Fulvimarina pelagi
AGJ98786   16 IREVKVLADNIYEICRQYg------------nDIFLIADENTAKLLNKNILNKVshli---ipaTPIIPERDTGIYDGSQ 80  Wolbachia endosymb...
EMS95639   23 YEKIVIEDNLDGAEASLVasln-------lgnRFTVVADPDTWDAMGSRVANALgt------lgPVETVILDHPHADMAA 89  Agrobacterium tume...
EIM28805   18 TRQVFVSSAALAFLPDAVrsa--------ggrVPMIIADRNTMEAAGRDALASLgqvg--ladiEPILLEAVPRVKPHAS 87  Microvirga sp. WSM...
AEC02642   10 TKKLDVGRDIISHVPVIFsdfma-----sggySPLVIADEITWEVAGRQVQTELdtagl-spaaPFIFPGTPMLYADEKA 83  Spirochaeta coccoides
Feature 1                                          ###  #  #              ## #                
B3EYN8     98 IVQVLLetp------------------ddvDVLIAVGAGTIHDITRFSSYKmRIPFISVPTAPSVDGFTSMGAPLII-RG 158 Geobacillus stearo...
AFS48447   98 KGVEFLrskl-----------------kdyDGMIAVGSGTVSDSIKYATFL-EGKVYSVFATTPMNAYTTGTASISF-DG 158 alpha proteobacter...
AEH50234   69 NVEKLLkva------------------kdyPSLVSIGSGSITDVVRYAAYLlKKPFSAFPTAPSVDGYTSSVAPLLV-NN 129 Thermotoga thermarum
ABV34079   76 KVLKILgn---------------------eDMIVSIGSGSLTDIAKYAAYLsKKEFSCVPTAPSVDGYTSSAAPLMV-NG 133 Thermotoga lettingae
EKE74328  105 VRDLQKltr-------------------nhDALIAVGSGTINDLCKYATYLdGRAYSVFGTAPSMNGYTSSTASITLeSG 165 Celeribacter sp. L-6
EAU39692   89 LDDLADrls-------------------ehTGAIAVGSGTINDLTKYVVGRdGRPYCVFGTAASMNGYTSSTASITLeSG 149 Fulvimarina pelagi
AGJ98786   81 CHATWMtpnrlnsaaslqavnlvrnkakdsDLMVAFGSGTVNDICKYASYLeKKDYISFPTAASMNGYSSANASILV-DG 159 Wolbachia endosymb...
EMS95639   90 VADLTEklk-------------------daEAVIAVGSGTINDLCKFVTGKtDRRYAVFATAASMNGYTSTTASITLdNG 150 Agrobacterium tume...
EIM28805   88 LARGIAdaik-----------------aqgAIPVAVGSGVINDLTKYAAEIaGVPYVCVATAASMDGYAASGAALLD-DG 149 Microvirga sp. WSM...
AEC02642   84 IAKAQDalsr-----------------hpnCRCIAVGAGSINDIVKAASGAlGQPYMVVATAPSVDGYTSAGAAVSI-HG 145 Spirochaeta coccoides
Feature 1      ##               #       #      #   #                                          
B3EYN8    159 VKKTIqAQAPIAVFAHTGVLCQSPKEMIAAGFGDMVAKYTSLADWQFAHWMADEPYCPfVHQLTEQSLQTCVDHidd-ia 237 Geobacillus stearo...
AFS48447  159 VKKSLiAHYAQGVFFDLEVLSNCPKRLTAAAFADVICRTTAQVDWLMSHKLLNTDYKTtPYELLALYEMDMINNasd-ia 237 alpha proteobacter...
AEH50234  130 IKKTLpAKTPTVILIDLEILKNAPIDLLKAGIGDIAAKVTARLDWMVANKLLDEGICDfTWENLKDYLVDVLKNpnr-il 208 Thermotoga thermarum
ABV34079  134 IKQTLdAKTPRTIILDIDILRNCPLDLLRAGIGDISAKVIARFDWLLSHHITGEYICDfFWNNLEDVLFELLKDvnn-if 212 Thermotoga lettingae
EKE74328  166 LKTTQkAHAAKGVFIDIDVSSKAPQYLIGAGLGDSLCRPTAQVDWYFSHVMLGTRYATaPYLLQEDDEAEVLRRsad-lg 244 Celeribacter sp. L-6
EAU39692  150 LKTSLpSTAPKGFFADLTVMAEAPTFTRAAGFGDCMARSTAQIDWWMAHRLTGSDYQQiAYDIEWNDEVELNKRaag-vg 228 Fulvimarina pelagi
AGJ98786  160 YKKSFgAHLPKAIYIDTDIIANAPPRLTLSGFADFICRSTVQADWLLSHLLLGTEYNElPFKLVRNLEEILLREhla-la 238 Wolbachia endosymb...
EMS95639  151 LKVSLpSHAPAGFFVDLGVTAAAPRFLSASGFADCLVRSVAQIDWWMSHRLLGSLYST-VPYILQEKDEAELNArahgla 229 Agrobacterium tume...
EIM28805  150 FKRTLdCAPPVSIVADLDVIARAPARMAGWGYGDLAGKIVAGADWKLADLLGEEPINHePFALVQDNVRGWLSQpda-ig 228 Microvirga sp. WSM...
AEC02642  146 FKQTVpCPAPVVVVADTGILSAAPYDMIAAGYADLAAKLPAGADWLVADFFGTHLLHPaVWDMIQTPLHAQVRSsag-ia 224 Spirochaeta coccoides
Feature 1                                       #   #               #                         
B3EYN8    238 aGGEQGIRVLMDALLQSGIAMLLMGQSYSASGAEHHLSHYWEMeflrqkkrqvLHGAKVGVSTPIIIEHYqrvfwpllne 317 Geobacillus stearo...
AFS48447  238 aGKIDSLALLTLISAIMGLGTSFTQTTHVGSMGEHGISHYIDMfagdl-hpgtSHGEQVGIATISMSKFQnailkkdqpp 316 alpha proteobacter...
AEH50234  209 dRDEISIKSLMEGLLVSGLNIATVGHSRPASGAEHVISHFIEMyhefhgeyppFHGITVAMGTFITLKAYevlmnnvklq 288 Thermotoga thermarum
ABV34079  213 qREKNFVSKLMTAQLISGLNITVAGNSRPASGSEHLISHFLEMvyeargelplFHGLQVAMGTYISLHAYeilfediple 292 Thermotoga lettingae
EKE74328  245 lGEHDAIGYLQRLLTLGGLGIAVVGMSHPGSMGEHQISHWIDSfagdr-hpgtVHGQQVGVASITMARLQdhilsleeap 323 Celeribacter sp. L-6
EAU39692  229 aGDIEAMGYLTRVLTLCGLGIAFTGVSNHGSMGEHQISHYIDCfmgea-hpgtLHGQQVGVASLTLARLQqqilsreepp 307 Fulvimarina pelagi
AGJ98786  239 kKDKKVVLLLMEALLISGLGMVMSKGSYSASQGEHMIAHAIEMvtqd--ysssLHGEKIAVTTITMANLQeeilsiqnpi 316 Wolbachia endosymb...
EMS95639  230 aGDVAANGYLHRVLAFCGLGVSFTGMSNHGSMGEHQISHYIDCfagrr-hggtLHGQQVGVATLTMARLQahylaseapp 308 Agrobacterium tume...
EIM28805  229 aGNPAAMGDLVNGLLVSGFAMQAHGNSRPASGAEHLISHVWEMerltyegepaAHGACVGIGTVAILALYewflgqhide 308 Microvirga sp. WSM...
AEC02642  225 aRDPSTISSIFTGLCNTGFAMQRMHDSRPASGAEHLMSHVWEMdhlehdglpvSHGFKVALGTLASTAFYeeffalgcda 304 Spirochaeta coccoides
Feature 1                                                                                     
B3EYN8    318 lekrpksm---------------------------------------deatwerlkantasireLLESLPSPERIRTMLA 358 Geobacillus stearo...
AFS48447  317 iisptiipedeiiqkigapmlet---------ikkamepkmfdqkkaeetneyfskhwlefvepLREKMLDYEVMWNSMG 387 alpha proteobacter...
AEH50234  289 qkripldykkeklktlfn-------------------teiadefckiyetkrraekinlreivkTIKPVYQEYSKSAFEA 349 Thermotoga thermarum
ABV34079  293 kssdnleekkrsliqlfg-------------------pkkaenflriyrnknmvkianlnkikkSLEKTYLRFSPLLKNV 353 Thermotoga lettingae
EKE74328  324 rirgwqpdevairarypaaaved---------clkasrakamdaqatevfnrqlaeiwpelrttLRAMMLAPDNMARHLR 394 Celeribacter sp. L-6
EAU39692  308 himptlidyddmvrrmgrriadd---------claefqkkaldeagastmnerlrkvwpelrreCLAFAIPVAEMERLLK 378 Fulvimarina pelagi
AGJ98786  317 tkpitldvkhitqcfgnte----------------fikilkqkqmmqqkiqeiickewsnisslIKQNLLSAKHLQKVFE 380 Wolbachia endosymb...
EMS95639  309 virptiidpddmarrmggdiaah---------claeiqpklfdaraaaamnekfaelwpvlreeLKAFALPVSEMERLLR 379 Agrobacterium tume...
EIM28805  309 nvvaqargaastpeaveaeieaaftdrhiadsartemrvkmeraprraerlatlaadwpalreeLRRYCIAPDEMETWLR 388 Microvirga sp. WSM...
AEC02642  305 lrsrlsawkkpswedreqeicswlkgqhnlddvlrvsrekfpapslwdemleslcskwdslndiIRKQLIPFPELREHFV 384 Spirochaeta coccoides
Feature 1                                                 
B3EYN8    359 KVGGAIAPEqlGIDPQLVERSLREAHrLRLNRFTMLyflnELIF 402 Geobacillus stearothermophilus
AFS48447  388 ECGALRTAEdaKLDSNFYKDALKYGRfIRDRYTILDla-gDSNQ 430 alpha proteobacterium HIMB59
AEH50234  350 LSQISVHEFfnRYDKDFLKQVIILTNmTRDRYNILDvl-dQLDL 392 Thermotoga thermarum
ABV34079  354 CKVIDVGELfkNYSRDVIKQAINLSNmLRERYTVLDfl-dSSGI 396 Thermotoga lettingae
EKE74328  395 ASGGGATYDeiGLERGLYIDALRHCReMRDRYSMLDla-dDMGI 437 Celeribacter sp. L-6
EAU39692  379 AAKGATTAEelGIPAGFYREAIIHNReMRNRFSLLDia-aDAGL 421 Fulvimarina pelagi
AGJ98786  381 DLSIPYLPEhlNWNKEQYCKVVNLTFvTRDRFTFLDla-gCIEK 423 Wolbachia endosymbiont of Drosophila simulans
EMS95639  380 EAGGPMTAAdlGLPVEFYRESVLHCReMRNRYSFLDia-aDEGI 422 Agrobacterium tumefaciens
EIM28805  389 AAGAAAHPGdlGLPLAQLAKEYRRARlIRRRFTILDll-dDLGW 431 Microvirga sp. WSM3557
AEC02642  385 TAGCPVEPAdiGLSREEFHKGMHVSGmIRNRFTILDlm-fITGV 427 Spirochaeta coccoides

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