Conserved Protein Domain Family
SET_SETD5
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cd19181: SET_SETD5 
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.
Links
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Statistics
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PSSM-Id: 380958
Aligned: 4 rows
Threshold Bit Score: 334.284
Created: 12-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative SAM
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ##                #         #         ########                 
Q9C0A6        266 GSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNgvEMCVDARTFGN 345  human
AAH84951      114 GSQMQLQLGRVTRVQKHRKILRSAKDLASNTFVIEYRGKVMLRQQFEVNGHFFKRPYPFVLFYSKFNglDMCVDARTFGN 193  African clawe...
NP_001264946  302 GSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNgvEMCVDARTFGN 381  chicken
XP_007888442  302 GSQMQLQLGKVTRVQRHRKILRAARDLTPDMLIIEYRGKVMLRQQFEVNGHFFKRPYPFVLFYPKFNevEMCVDARTFGN 381  elephant shark

Feature 1           #####       #               #          #######                      
Q9C0A6        346 DARFIRRSCtPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYsnCNYKVDCACHKGNRNCPIQK 415  human
AAH84951      194 DARFIRRSCtPNAEVRHMISDGMVHLCIYTVAAIAKDAEVTIAFDYDYsnCNYKVDCACHKGNRSCPILK 263  African clawed frog
NP_001264946  382 DARFIRRSCtPNAEVRHVIADGMIHLCIYAVATIAKDTEVTIAFDYEYniCNYKVDCACHKGNRNCPVQK 451  chicken
XP_007888442  382 DARFIRRSCaPNAEVLHMIADGMIHLCIYAITNIPKDSEVTIGFDYEYssCKYKVDCACHKGNQNCPVQK 451  elephant shark

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