Conserved Protein Domain Family
DUF4586
?
pfam15239: DUF4586 (this model, PSSM-Id:405836 is obsolete and has been replaced by 434561)
Domain of unknown function (DUF4586)
This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.
Links
?
Statistics
?
PSSM-Id: 405836
Aligned: 36 rows
Threshold Bit Score: 168.341
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q57V66         5 SAFGGLFSDPPLVS----TDidpkktDPYd-kMDTIPSrYLGKGMSIG------------RCPSGNGPEVFFDK-KFLTL 66  Trypanosoma brucei
XP_002424612  17 IERCDLFADLGFLDwekyTG------NFY----------ILNESSRKGrqmyssvpsgghKKCGLQGASGYFDK-KFQSI 79  human body louse
XP_002508712  26 pdKYGSFSNPGSLN----VG------VPYt-gKDPLAQgnsrlrg---------vnmkapSAKMGKGNDASFDR--FKPL 83  Micromonas commoda
XP_003063000   2 sNKYGTFSDAGYLA----VG------DPYldgKDPLAQssryrg----------lnmkasTRKTGKDNRACFDK--LKPL 59  Micromonas pusi...
A0CLN6        23 RERHGLFNQPPPLL----IG------DQY-------NDaLKSQGKEKGvl--------vnKKLQKKHEPTLFLEpGYTTL 77  Paramecium tetr...
XP_004040205  33 KQRFALFSQPPSLA----TG------D------DKQYQkIYHQRDENGkpitearniqstALKRGKAKDAYFSVlGFTTI 96  Ichthyophthiriu...
A0CX61        25 VQRFGLFSSPVPLG----LG------D------NSYDNkPRPARNEQGkpitsppnmkvtATQSGKIKSSYFSQlGFTTI 88  Paramecium tetr...
A0E6W5        28 KQRFGLFSSPVPLG----LG------D------DSMEMrKRPQRGENGkpitepsnmkvcATRTGRIRSSYFGPlSFTTV 91  Paramecium tetr...
XP_001566595   5 SAYGGLFQDPSYLS----SDpdprktDPYd-kKDAIPSrYLGKSMTVGg-----------RVPPGQHPDAYFDK-KFLTL 67  Leishmania braz...
CBZ12597      77 SVYGGLFQDPPYLS----SDpdpkktDPYd-kKDAIPSrYLGKNMTIGg-----------RVPPGQHPDAYFDK-RFLTL 139 Leishmania majo...

Q57V66        67 ASAEqnnnksvgPFEDATTRMHRERREAKKHNISn--KDFLPPSFPKSINGPGGYSGC---------FQErpyefimpge 135 Trypanosoma brucei
XP_002424612  80 FVND--------PYSE--KWKTKGRPSEHPLN-----GSWIPSGPSKYHSTPGDYYGTftkasdmpaFSP---------- 134 human body louse
XP_002508712  84 YQKE--------PFQVSAAEKREARAKAEDGRIQ---GPLVPAGMPKKSSGLGGYGGTlg-----epFENedgepyfgwg 147 Micromonas commoda
XP_003063000  60 YANE--------KYALTNEERAARRETEKAGKVTd--KPFKPTSLTKHACGLGGYGGCig-----gkHESvpggdv---- 120 Micromonas pusi...
A0CLN6        78 --ND--------PYKDQFKAKQIYDKERELAIKNp--NCFKPNDHVKSIKHSE--------------FEHmkefn----- 126 Paramecium tetr...
XP_004040205  97 --GD--------KYIDPDSINRQYELEKKKKIKQd--QVFKPPSGYKTIINSA--------------FKHenedv----- 145 Ichthyophthiriu...
A0CX61        89 --GD--------KYIDPERKIRIQELEEKKKYANddkKNFVPPSGYKELVGGV--------------YNHeadyei---- 140 Paramecium tetr...
A0E6W5        92 --GD--------PYIDPEKVLTIYEKEQKKLCNKe--AAFKPPSGYKELMGSA--------------YSHmkeydy---- 141 Paramecium tetr...
XP_001566595  68 ASSEqngg--kpvgYDENKWCTTAKK-QTKKPISd--KEFRYSSYPERSTGPGSYYGC---------FQSrpyeymtepw 133 Leishmania braz...
CBZ12597     140 ASSEqngg--kpvdYDESKQRTAASRTNTKNAISd--KEFCYSSYPEKSTGPGSYYGC---------FQNrpyeymtepw 206 Leishmania majo...

Q57V66       136 eggpkskkskrkkkasSSEEDSKGKELLPNIKTNPSKKGT-YGYVGILLDNP---------KYN--DDWrkehEKLEAAE 203 Trypanosoma brucei
XP_002424612 135 ----------------LSRSIKRQGNELKNFLTNPGKKGNs-GYVNICINKY---------PPHsvNNKtdafTTAELLH 188 human body louse
XP_002508712 148 -------tadgeppkgLMKGDPSTQPKPRNIVTGPGKKGG-YGMRGYTLGEKksaggsageYKYvaTDY----DAERKAD 215 Micromonas commoda
XP_003063000 121 ----------dpndekLMKGDPRLDEKPRQITTCPGKKGS-YGTRGTTLGGPkghg-vageYSYkgDEY----DAERKAN 184 Micromonas pusi...
A0CLN6       127 -----------dkvfnTRTPKGDVRTQARNFLTNPAKKGLgRTTTNNLFGQ----------IEYipDPY----DRQEELD 181 Paramecium tetr...
XP_004040205 146 -----------ynkknYRDADGKVLTQSKNITTNPSSK---------LQSKH---------YPHlpDQY----ERQRQLR 192 Ichthyophthiriu...
A0CX61       141 ----------pkgpnnHKGGDGRVKIGPKNVTTNPGSS---------SLGHF---------PKHekDEY----NRYRQFE 188 Paramecium tetr...
A0E6W5       142 -----------kkvesRKQTDGRVYSAPRNVTTNPRCK---------VLDKS---------IPYltDDY----NRYSDFE 188 Paramecium tetr...
XP_001566595 134 ------ddgkskkrraAKPKEEEEPTHLPNIKTNPAKKGT-YGYAGLLLSNP---------IYN--DNWkdehAAAEAER 195 Leishmania braz...
CBZ12597     207 d-----dgkskkkkraPKPKEEE-PTHLPNIKTNPAKKGT-YGYPGLLLSNP---------SYN--DDWkkdyAAAEANR 268 Leishmania majo...

Q57V66       204 AKK-RKKlAPPKPLG-PLFRTPGV--IHDYLDE----------------LpATGVSGVYhfepadek--pskrkrkNKQE 261 Trypanosoma brucei
XP_002424612 189 SKN-WKN-HKEKFLN-GPFKAGFF--PRD-FDSnpygdpregkpkptyrTpTKKESDKKgd-------------niFYPP 249 human body louse
XP_002508712 216 AA--RAAhGKKLMAGkPDWKPTAPgkRGGPGVTgktla------gpknlGgVCGEYRYKpegpdpkfvpeppadypWAPP 287 Micromonas commoda
XP_003063000 185 AA--REReGKKKMQG-SAWAPARApkKGGYGTRgttig-------gpkgAgVVGEYSYKeegpelpepkgspiekqWRPS 254 Micromonas pusi...
A0CLN6       182 RQD-RIKhRSKFLPGtTRFITTSH--GNRPFTAdgill------dgagyLsAKKRPLYKga--------------pFRPA 238 Paramecium tetr...
XP_004040205 193 IQ--EMKkHQELLGEkAAFRSTVF--GRRNFFNdkktf------geeglNlKKRPQTNikfnii-------nhdapFKPS 255 Ichthyophthiriu...
A0CX61       189 RE--KIFnEQKMLKDkQPFKSTIY--TTDNFSTdkqif------getnlPkPTQVKEFKpnimk--------heapFKPS 250 Paramecium tetr...
A0E6W5       189 RKArMESkSKEKe---QPFRSTVN--GGYTFEKdknif------gvtkmPpQSQRKSPDlksak--------hesaFRPA 249 Paramecium tetr...
XP_001566595 196 ASKeRKQgPAPKALG-PPFHIPGV--SHSYIDE----------------MpNTGVSGVYaayeapadsaatknrkaKKET 256 Leishmania braz...
CBZ12597     269 ARReRKQgPAPKALG-PPFHIPGV--SHSYIDE----------------MpNTGVSAVYaayeapad-saaekrkaKREA 328 Leishmania majo...

Q57V66       262 AAGPTFVqeramtfvwtrSGNEGNIDPFPNTWIDVAAleeeekkknrrrrrakAKDTYvPGPPKGA--TGVWKP--N--- 334 Trypanosoma brucei
XP_002424612 250 AGPKDIG-----------RFPEGCFNKFTSWTPEPYKt---------------QRDVErEFTKKKSdpDNIFRP--Epr- 300 human body louse
XP_002508712 288 KPNK------------------GPMNPFPEHMADPEEl--------------qKWKERrREKEGRAkiTKAWRP--Ggg- 332 Micromonas commoda
XP_003063000 255 HPPK--------------RGYNATLQRFPKHMADPAEl--------------kIAAAReKMEADAEliEKPFVP--Pftg 304 Micromonas pusi...
A0CLN6       239 NQNK--------------NGFQGTFEVL-QYMEEGVPdp-------------kTKQNTfQKLSATQtyENPWRPnsNgtf 290 Paramecium tetr...
XP_004040205 256 NPNKRVFiyiikkificyKGWNGTLSKFPEYKPNG------------------EKQAKrQFMI-KE--KDPFKPkyCgel 314 Ichthyophthiriu...
A0CX61       251 NPTK--------------SGETGCLSKYPQYKGDP------------------LKPTQrIDFV-KG--KDPFKPnhLmem 295 Paramecium tetr...
A0E6W5       250 NGLK--------------KGFDGLFGHF-QYKSDP------------------MREIKrQFSSKKE--RESFKPadLgnk 294 Paramecium tetr...
XP_001566595 257 KAVPTLVherafcgyanrIGEQGCLNPFPNVWVHPDEmqlsksa------qrkqaqEEaGRPPKGA---GVWRP--N--- 322 Leishmania braz...
CBZ12597     329 AAAPTLVherafygsanrSGEPGCLNPFPNLWVHPDEtqpskia---lrkqaqKEKEEaARQPKRT---EVWRP--N--- 397 Leishmania majo...

Q57V66       335 --TFECTSVVQSCLR 347 Trypanosoma brucei
XP_002424612 301 lkSYYTVSVFnl--- 312 human body louse
XP_002508712 333 gkSGATKSVLRMNTr 347 Micromonas commoda
XP_003063000 305 ckSQATKSVVKMNLg 319 Micromonas pusilla CCMP1545
A0CLN6       291 arPCPSVS---QQLR 302 Paramecium tetraurelia
XP_004040205 315 trPTPTISCHPLNIR 329 Ichthyophthirius multifiliis
A0CX61       296 vrPTPSISCFPHNLK 310 Paramecium tetraurelia
A0E6W5       295 trPNPTISCFKMNIR 309 Paramecium tetraurelia
XP_001566595 323 --SFEKTSVVSSCLR 335 Leishmania braziliensis MHOM/BR/75/M2904
CBZ12597     398 --SFGKTSVVSSCLR 410 Leishmania major strain Friedlin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap