Conserved Protein Domain Family
PRK12758

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PRK12758: PRK12758 
DNA gyrase/topoisomerase IV subunit A
Statistics
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PSSM-Id: 237192
Aligned: 25 rows
Threshold Bit Score: 1417.08
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
255533353  23 LYENWFLDYASYVILDRAVPHINDGLKPVQRRIMHSLKE-MDDGRFNKAANVIGNTMKYHPHGDASIGDAMVQIGQKDLL 101 
189502210  21 MYQSWFLDYASYVILERAVPAIEDGLKPVQRRILHAMKE-MDDGRYNKVANIIGQTMQYHPHGDASIAEAIINLGQKELL 99  
294672800  34 MYQNWFLDYASYVILERAVPHLGDGLKPVQRRILHSMKR-MDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLL 112 
255036406  24 LYENWFLDYASYVILERAVPAIEDGLKPVQRRIMHALNE-MDDGRFNKVANVVGSSMQYHPHGDASIYDAIVNIGQKELL 102 
34541272   42 MYRNWYLDYASYVILERAVPHIEDGLKPVQRRILYTMHHwFDNGRMNKVAKVTGQTMALHPHGDASINDALVQLGQKGYL 121 
261414926  21 LYDGWFLDYASYVILDRAVPYFEDGLKPVQRRILHSMFE-NHDGRYQKVATIVGRTMAYHPHGDASIGDALVGLGQKNLL 99  
110638041  28 LYENWFLEYASYVILERAVPHINDGLKPVQRRILHAMRV-MDDGRFNKIANVIGSTMQYHPHGDASIGDAIVNMGQKDLL 106 
150009781  60 MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMRR-LDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLL 138 
284037117  55 LYENYFLDYASYVILERAVPAVEDGLKPVQRRILHALKE-MDDGRFNKVANVIGQTMQFHPHGDASIGEALVNIGQKELL 133 
302345857  43 MYKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKR-MDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLL 121 
255533353 102 IDCQGNWGDPITGDNAAAPRYIEARLSKFANEVVFNGDTTIWQLSYDGRNNEPVTLPVKFPLLLAQGAEGIAVGLATKVM 181 
189502210 100 IDMQGNWGDIRTGDSAAAARYIEARPSSLAHAILYSPQITSWQLSYDGRKKEPVTFPIKFPLLLAQGAEGIAVGLATKIL 179 
294672800 113 IDTQGNWGNILTGSSAAAPRYIEARLSKFALDTVFNPKTTEWKMSYDGRNKEPITLPVKFPLLLAQGAEGIAVGLSSKIL 192 
255036406 103 FDTQGNWGDIRTGDGAAAARYIEVRLSRFGKDVVFNDDTTEWQLSYDGRKREPITLPVKFPLLLTLGVEGIAVGLSTKIL 182 
34541272  122 IETQGNWGNILTGDEAAAGRYIEAKLSALAQETLFNDKITHWKRSYDGSEDEPVALPVKFPLLLAQGTEGIAVGLNSKVL 201 
261414926 100 IDTQGNWGNPYTGDRAAAPRYIEGRLTPFAVDVVFNPETTEWIPSYDGRSEEPVTLPVKFPLLLAQGVDGIAVGLSTSIL 179 
110638041 107 IEPQGNWGDIRTGDSAAAPRYIEGRLSKFALDVVFNEDTTEWQASYDGRKKEPVTLPVKFPLLLAQGVEGIAVGLSTKVL 186 
150009781 139 IDCQGNWGNILTGDGAAAPRYIEARLSKFALETVFNPKTTLWQLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKIL 218 
284037117 134 FDTQGSWGDVRTGDGAAAPRYIEVRLSKFAQDAIYNDKTTEWQLSYDGRKREPITLPVKFPLLLAQGVEGIAVGLSTKIL 213 
302345857 122 IDMQGNWGNILTGDRAAAPRYIEARLSKFALETVFNPKTTEWQLSYDGRNKEPITLPVKFPLLLAQGAEGIAVGLSSKIL 201 
255533353 182 PHNFIELLDASIEALQGHRPNILPDFFTGGMADFSAYNEGMRGGRIRVRAKITEKDKKTLVITEIPYSTTTGSVIDSILS 261 
189502210 180 PHNFCELIEGAIAVLQGKTTNLLPDFPTGGLVDCSAYNEGKRGGRIRLRARIEILDKKTLAIREIPYGTTTNSLIESIIR 259 
294672800 193 PHNFCEICDAAISYLHQQPFALYPDFPTSGSIDVSKYNDGQRGGVIKVRAKIEKIDQKTLVIREIPFSKTSETLQDSIVK 272 
255036406 183 PHNFCELIEASIGILQGKEVTIYPDFLTGGLVDVSNYNDGHRGGKVRVRAKIEEEDKKMLVIRDIPFGTTTTSLIESIIK 262 
34541272  202 PHNLGELLMACIAHLRGESFDLYPDFPTGGMMDASRYNDGRRGGQIKSRAKIRKLDNRTLSITELPCGKTTSSLIESILK 281 
261414926 180 PHNFRELCEASIACLRGKKFTLYPDFFTGGIIDVSDYNDGQRGGKVKVRAKIEKVDNKTLAIREIPYGTTTVSLIESIVK 259 
110638041 187 PHNFVELIEASIAVLKNKKFEIFPDFATGGFIDVSNYNEGQKGSRVRVRARIEDMDKKTLVIKDIPFGTTTTSLIESIVK 266 
150009781 219 PHNFNELLDASIAYLRGEEFALYPDFQTGGSIDIAKYNDGERGGSVKVRAKIGKLDNKTLVISEIPYGKTTSTVIESILK 298 
284037117 214 PHNFNELIDASINILKDKPVSLFPDFQTGGLIDVSNYNDGHRGGKVRVRAKIEEVDKKILAIRDVPYGVTTSQLIDSIVK 293 
302345857 202 PHNLNDICDAAISYLRGEEFNLYPDFPTGGSIDVSKYNDGQRGGVLKVRAKVEKLDNKTLVIREVPFTKTANTLQESITK 281 
255533353 262 ANDKGKIKIK-------KIEDNTAAHVEIVIQLAPGISPDVTIDALYAFTSCEVSISPNTCIIKDEKPQFLSVNDILIEN 334 
189502210 260 AYERGKIKIK-------QVIDNTAEDVEILVHLAPGQSPDVVLDALYVFTDCEIGISPNTCVIKDEKPTFIGVNELLEYN 332 
294672800 273 AIEKGKIKAR-------KVEDLTAAEVEIQVHLAPGVSSDKTIDALYAFTDCEVSISPNCCVIEDNKPQFLTVSDVLRHS 345 
255036406 263 ANDAGKIKIK-------KVVDNTAADVEIQVHLAPGVSPDITMDALYAFTECEVSISPNACIIIAEKPHFVGVTDILKYN 335 
34541272  282 ANEKGKIKIK-------RIDDMTAAEADIRIHLAAGVSSDKTIDALYAFTDCEVSQSPNACVIMDDKPVFLGVTDLLRYS 354 
261414926 260 ANDKGKIKIK-------HVDDNTSQGVEILVHLQPGTDPQVAIDALYAFTDCEKSLSPCTCVIIDKHPKFVGVSDILKLN 332 
110638041 267 ANDTGKIKIK-------KVIDNTAKDVEIQVQLLPGTDPGITIDALYAFTECESSISPNACVIVDDKPHFLSVHEILRIC 339 
150009781 299 ANDKGKIKIK-------KVDDNTAKDVEILVHLAPGVSSDKTIDALYAFTDCEISISPNCCVIKEDKPHFLTVSDVLHHS 371 
284037117 294 AAELGKIRIKapsrnvaAVVDNTAKDVEILVHLQPGVSPDVTIDALYAFTDCEVSISPNACVIIGDKPHFVSVTDILRVN 373 
302345857 282 AVEKGKLKIR-------RVEDMTASEVEIQLHLTPGTSSDKTIDALYAFTDCEINISPNCCVIRDNKPEFLTVSDVLRNS 354 
255533353 335 SMHTKALLKKELEIKLHELQEKIFFSSLLKIFIQEGMYKnaEYENSVNFEMVVEVLNRLFEPFKPGLYRE-ILPEDFKKL 413 
189502210 333 TYRTKDILQQELTLQHKNLQEKILFASLEKLFIEKRIYR--DIEESETWEQVLLTIDQGLEPYKKQFYRA-IIEDDLVRL 409 
294672800 346 VERTKDLIRQELEIRKGELLEQLHFQSLERIFIEERIYKdkKFEQAPNVDAVCEHIDERLTPYYPQFIRE-VTKDDILKL 424 
255036406 336 TQQTVHLLQRELEIKRLELLEKILYGSLEKIFIENRIYR--DIEECETFEAVIRTIDKGLEPFKPQFYRE-ITDDDIVAL 412 
34541272  355 AERTRELLKQELTIRLEEKREQYLAASLERIFIEERIYKdrEFEEAESEQDALMHVEARLEPYAHRFIRP-ITYDDLKKL 433 
261414926 333 TEHTVKLLEWELANELKHLEDKWHMTTLEKIFIEKEVYE--VIKKAKDREQIIRLVREGLTPYLKRLHRQtVTDEEIGKL 410 
110638041 340 TRQTVDLLKQELQIRRSELLERILFSSLEKIFIENRIYR--KIEECETWEDVLLTIDKGLQPFKKQFYRT-ITTEDIVRL 416 
150009781 372 TDRTLELLREELKIQKQEQEEALFFASLEKIFIEERIYKdpEFENAKNMDEAISHIDLRLEPFKPRFIRE-VTRDDILKL 450 
284037117 374 THQTVHLLQRELEIRRSELMERLLYSSLEKIFIENRIYR--KIEECETFEAVLEAIDKALKPHKKLFYRV-ITQDDLIRL 450 
302345857 355 AEHTKALLKLELEIRKHELEEQLFYNSLERIFIEDRIYKerKFETAKDIDEVVSFVDSKLEPYKKTFIRE-VTRDDIIRL 433 
255533353 414 IDKPMSSITRFDVKKADEQMKALSDEIKVVKNHLRHLTEYAIAWFQKLKDKYGKGRERKTEIRLFDRVEASKVALANVKL 493 
189502210 410 TEIKIKRISKYDSQKAEDALLVLEKELAEVEHHLQHLTTFTIQYFKNLLKKYGAGKERKTEIRTFDTIEAHAVVANNQKL 489 
294672800 425 LEIKMQRILKFNKDKADELMARLKAEIEEIDRDLANLVEVTANWFQFLKDKYGKDHPRLTEIRNFDTIDSAKVAEANQKL 504 
255036406 413 TEIRIKRISKYDSFKADELMRKWEADLAETEDNLAHITRFAIEYFRDLLKKYGKNRGRRTEIRAFNQIAANIVAANNQKL 492 
34541272  434 LEIRMARILRFNLPKHEAMMLQLEKDIAELEKNIREITAYTIRWFEYLHEHYASRFPRRTQLIGFSTIQATKVAEANAKL 513 
261414926 411 IEIPIRRISHYDREKADQLLQELEENIAKCKYNQEHIIDYAVNHFKNILKKYGEGKERRTQIAEFGKVNAVHVALANQKL 490 
110638041 417 TEIKIKRISKFDSFKADELMRGYSNELKEVEHNLENIIDYSIAYYTGILKKYGKGRERKTEIKTFDVINATVVAANNQKL 496 
150009781 451 MEIKMGRILKFNSDKSNEFIAQTLEQIAKINDKLEHIIDYTIDWFTMLKEKYGKAYPRHTVIRNFDTIEATKVVEANEKL 530 
284037117 451 TEIKIKRISKYDGFKAEELMRRLEQELAETEDNLANITRFAIAYYKDLQKKYGKGRERKTEIRAFNTIAASVVAAANQKL 530 
302345857 434 LEIKMQRILKFNKDKADELIQKIKAEIAEIDKDLSEMVRVTIEWFTHLKEKYGSDHPRRTEIKSFDTIVAAKVVDANEKL 513 
255533353 494 YMNREDGFIGTGLRKDEFVADCSDIDELIVFREDGKCIITKVADKTFVG-KGILHAQVFKKGDERTIYNMIYKDGASGVS 572 
189502210 490 YINRKQGFIGYGLKKDELIGDCSDLDDVIVFRKDGKCLVVKIAEKVFVG-KDIIHAAVYKKNDERRVYNLIYIDGKTGIA 568 
294672800 505 YINRSDGFIGTGLKKDEFVCNCSDLDDVIIFYKDGKYKIVRVAEKLFVG-KNILYVNVFKKNDSRTIYNAVYRDGKKGAC 583 
255036406 493 YVNRAEGFVGYGLKKDEYVMDCSDIDDIIVFRGDGRCVVTKVQDKVFVG-KDIIYCAVFVKNDERKVYNVVYVDGKTGVS 571 
34541272  514 YINREEGFIGMGLKGDEFVCNCSDLDDVIIFFRDGTYLITKVEEKKFIGnREVIYIDRFERNDKRTIYNVIYRDGKSAPF 593 
261414926 491 YVNRKEGFVGTGMKKEEYLFDVSEYDDLIVFKADGSFKVVKVSDKDFVG-KDIILVEKFNKDDERHIYNVIHQDGKDGYA 569 
110638041 497 YINRAEGFIGFGLKKDEYICDCSDIDDVIVFRRDGICVVKKIGEKVFVG-KDILYAGIFRKGDDRMVYNLISLDGASGNS 575 
150009781 531 YINRQEGFIGMGLKKDEFICNCSDIDDVIIFYRNGTYKIVKVADKIFIG-KDILYVNVFKRNDNRTIYNVIYRDGKFGYN 609 
284037117 531 YVDREGGFIGYGLKKDEYVSDCSDIDDIIIFRRDGKCMVVKIAEKVFVG-KDIVYVSVFKKNDERKIYNLVYLDGKSGIS 609 
302345857 514 YIDRQEGFIGTGLKKAEFVQNCSDLDDVIIFYRDGKYKVIRIADKVFVG-KGVLHVQVFKKNDKRTIYNVVYRDGKTGPY 592 
255533353 573 YIKRFAVVGVTRDKEYDLTKGSKGSKVLYFTANPNGEAEIVTVQLKPHSKLKK--LQFDLDFAEIAIKGRGSQGNIVSKY 650 
189502210 569 RAKRFQMLGIIRDKEYDVTIGSTGSRILYLTDNPNGNAEVVTVILSPNSPARN--KVIDFDFASLQIKGRNSQGNILTKY 646 
294672800 584 YIKRFNVTSMTRDKEYDLTQGTDGSRVMYFTANPNGEAEVIKVTLDPSQNIKR--VFLVKDFSEIMIKGRASKGNLLTKY 661 
255036406 572 YAKRFQVTAVTRDREYDLTQGTPKSKITYFTANDNGEAEIITVNLQAQSKAKV--KQFDYNFAELLIKNRSAMGNILTKY 649 
34541272  594 YIKRFSVTGVTRDKEYNLTQETAGSRVMYFTANKNGEAETVRIILKPKARQRV--LSFEKDFSNVAIKGRSSKGNLLTKA 671 
261414926 570 YIKRFNVGGVTRDKDYYMGKNKPGSKILYMSSNMNGEAEVVEVILKPRPRIK---LNFEVDFSEVEVKGRGAIGNIVSKY 646 
110638041 576 MVKRFNVMGVTREKEYPLVKANKASKVLYFSANPNGEAETVSVTLTPTSKAKI--KVFDFDFSTIEIKGRDTQGNILTKH 653 
150009781 610 YIKRFAVTGATRDREYDLTKGTENSRVLYFSANPNGEAETVKVILKPKPRQKL--LVFEKNFSEIAIKGRGSQGNILTKA 687 
284037117 610 MAKRFPVTGVTRDREYDLTMGNPKSKLTYFSANDNGEAEVITINLTAQCTAKI--KQFDFDFASVGIKNRSAQGNILTKY 687 
302345857 593 YIKRFNVTSITRDKEYDVTLGTPGSKINYFTANPNGEAELIKITLDPNPDKKKqnIFMERDFASILIKGRAAKGNLLTKE 672 
255533353 651 PVKKILLKSKGVSTLSGLKIWYDDLLRRLNVDGRGKYLGEFDGEDKILQVHKDGWYELSTFELSNHFDAD-LILIQKFDP 729 
189502210 647 TIKKIQLKVAGQSTLGALEVWYDEHIGKLNTENRGKWLGTFKEDDRVLLLLQSGQYMLTNYALTNHYEPDqVILLEKFDP 726 
294672800 662 QVTRIGLKSHGHSTLGGRKVWFDPDVNRLNYDDHGKMLGEFYDDDQILVILSNGDYYLSNFDLANHYESN-ILRIEKYDA 740 
255036406 650 PVRKITLKAAGRSTLGGVDMWFDPIIGRLNRDERGEYLGNFGPSDNIVVIYKDGSYELTNFDLTNHYEPHeVLLVKKFDT 729 
34541272  672 EVHKILFKQQGASTLGGRKVWFDRDVMRLNYDEQGEYLGEFQANDSMLVILDNGDCYTTSIAENNHFDPN-MIRIEKYRP 750 
261414926 647 PVKTVKRLRKGVSTLGARVLYFDAPSGIVSTQKKGDCLGEFGENDKLLIIKQDGSARVHTMADPILVGSN-IKYLHKYDP 725 
110638041 654 PVKKVTFKAAGESTLAGTEIYYDETIGRINTDKKGLLIGSFASEDKILATYKDGTYEVTGFELTNRYDADqLLSIEKHNP 733 
150009781 688 EVHKISLKQKGSSTLGGREVWFDWDVLRLNYDGRGEELGEFHSNDQILVILPNGDFYVTNFDLSNHYESN-IMVIEKYQP 766 
284037117 688 PVRKITQKSGGVSTLGGVDIWYDEHLGRLNRDERGRLLGNFDAKDCILVVYKDGLYELTSFDLTNRYEPNeIAILVKFEP 767 
302345857 673 SIHRISLKSHGHSTLGGRKVWFDPDVNRINYEDHGRYLGEFSDQDSILVILKNGEFYITNFDASNHYEDN-ILRIEKFDA 751 
255533353 730 EKPFAVVQYEGKAKNY-FIKRFLFEaiAVGKKVSLISEENGSKFLYLSSNPAAVLTVDVLKGKTQvPETLEIVLAEFIDV 808 
189502210 727 KCIVSAVYYDGKTKQH-YVKRFHIEttVLDKKFCFISEARNSKLIIATVTATPQICMEYSIAVGEaTQNLIYDLGD-LPV 804 
294672800 741 DKVWTAVLYDADNQGYpYLKRFQMD--ATKKKQNWLSDNPASQLLLLTDTPYPRLQVTYGGADAF-RGSEEIDAEQFIAV 817 
255036406 730 KLPITAIYFDGGQKQH-FIKRFNIEtsSLDKKFLFISDAKNSKLILASTDVRPRLEIVYPKTAQKeQSTEEYLVEDMVDI 808 
34541272  751 EKIWTAIYHNRE-AGFpYLKRFKIE--NGSRDNMLGGEAEGNSLLLLSDTRYPRFALTFAGIDAT-RPELIVEGEDFVAV 826 
261414926 726 AQVFTVLYFEGSNFNY-MVKRFNLEgcPMTTEFSVVSDHKDTKLIELFATDDARELMEYQVGRE--VQKEELDLTEIAEV 802 
110638041 734 EAIVSALYLDAPSKTY-YIKRFKLEttTLGKRFAFIPDGKGNQVLFISTDDKPKIKIDFAKGKYVtNPTMIVSIDEFSEI 812 
150009781 767 SKIWTAVLYDADQKYY-YIKRFLLE--VNTRKQNFLGENPKNRLMLLTDEVYPRIEVIFGGHDAF-REALVLDADEFIAV 842 
284037117 768 DTVLSAVYYEANQKAW-YVKRFKVEttTIDKKFNFIGDVKGSKNLAVTADRYPRIEITHQVKDRGpLEKMVLEPEGFIDI 846 
302345857 752 DKPWTAVIFDADNQGYpYLKRFQME--ASKRHQNFIGDNPDSQMVLLTDVAFPRIQITYGGADAA-RGTEEIDAEQFVGV 828 
255533353 809 KGIKANGNRLTAHEVKNITISNhteiepaeevkvvsvaneaedefqedeaaatniengeelvdpalskdadeeeaPLPEP 888 
189502210 805 KGWKAVGSRLSKYIIKEITLLP---------------------------------------------------------- 826 
294672800 818 KGYKAKGKRLTTYALENIEELE-----------------------------------------------------PTRFP 844 
255036406 809 RGWRAQGNRIPNDKFKDIRWLE-----------------------------------------------------PLAVP 835 
34541272  827 KGIHAKGKRLTTYKLDGAKELS-----------------------------------------------------PVRDE 853 
261414926 803 KGYKALGSKFTAKKIKRVSRIS---------------------------------------------------------- 824 
110638041 813 KGWKSIGNKLGTNKINSISRLE-----------------------------------------------------AKKT- 838 
150009781 843 KGFKAKGKRISTFEVETINELE-----------------------------------------------------PNRFV 869 
284037117 847 RGWKALGKILPFAKVKDVKLLA-----------------------------------------------------PKVVK 873 
302345857 829 KGFKAKGKRLTTWTVDKIEELE-----------------------------------------------------PTRLP 855 
255533353 889 EipatEKPAAA--------------------EKPKKQWDsgatkpaeapkpkKETGPAkeksadetkpkkepiakpepeq 948 
189502210 827 -----VQQEHD--------------------------------------------------------------------- 832 
294672800 845 E----PPAETAdad---------------tePEEEDLDP-------------DAGKSE---------------------- 870 
255036406 836 TeepaETVTGEapdddnaeeateetanaleeNTVIPTEP-------------EDETEAsaadgdeesk------------ 890 
34541272  854 E----PDEETTdp-----------------dESFAEVAP-------------EAIASD---------------------- 877 
261414926 825 -------------------------------PADPFSDG----------------------------------------- 832 
110638041 839 -----------------------------------AEKP----------------------------------------- 842 
150009781 870 PsenaSESDDT--------------------EGNEEENDt------------DDGQST---------------------- 895 
284037117 874 EpvspELIIVT-----------------------DPVTA----------------------------------------- 889 
302345857 856 E----EEKTDDesneddvq-----eensaatEKEENLDP-------------DAGKSQ---------------------- 891 
255533353 949 eekpakkidfeitnpDDIKIDDKGQLGF-F 977 
189502210     ------------------------------     
294672800 871 ---------------QQIRDELTGQLNL-F 884 
255036406 891 ------tksetkpkkDKKGPDSKKQLGL-F 913 
34541272  878 ---------------EDIRDELLGIQRLqF 892 
261414926 833 ---------------SGESEGSNEDPSL-F 846 
110638041 843 ---------------KKDDGYVAGSTIE-L 856 
150009781 896 ---------------TDIIDEITGQMKL-F 909 
284037117 890 ---------------PEAEEKESIQLGL-F 903 
302345857 892 ---------------QQVIDEITGQLNL-F 905 
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