Conserved Protein Domain Family
Complex1_LYR_LYRM1
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cd20261: Complex1_LYR_LYRM1 
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins
LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.
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Statistics
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PSSM-Id: 380756
Aligned: 36 rows
Threshold Bit Score: 57.6364
Created: 4-Apr-2019
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O43325         8 EVLGLYRSIFRLARKWqatsg---------------------------qmedtIKEKQYILNEARTLFRKNKnl--tdTD 58  human
XP_003060466  57 RALSLMRSMLRCSMGWqgd--------------------------------rgRREAEYIVLETSKAFRARRda--tdPA 102 Micromonas pusi...
XP_007511486  13 EVLSLFRHMFRLARKMkr---------------------------------dsLKEAEYITSECKNRFRENRfl--kdHA 57  Bathycoccus pra...
SPR01919       4 AALNLYRRILRASRRFg------------------------------------PDEGRTIRDEARSLFEKNAal--tdAQ 45  Plasmodiophora ...
NP_001129840   9 RVIQLYRQILKLGKNWkake-----------------------------etntVVERQQIITEARQAFREHQqe--kdPI 57  Caenorhabditis ...
GBF90568      10 RAIALYRRILRAARTWqg----------------------------------pQEERAYIESTAKAEFRRDRnl---pPP 52  Raphidocelis su...
XP_003079011   4 RVANLYRRIARVARALp-----------------------------------tKRERMDALGEAREGFRAET------ST 42  Ostreococcus tauri
XP_002673867  12 KVLSLYRQILKLGNEWekhctkqmtsfhkniyerqfitfeqdaqdyhkgdeeiEREKEYIIDQAKSQFRSFKnl--tnPE 89  Naegleria grube...
KFH67759      10 RVLGLYRQLLKIGKAMp-----------------------------------tETRSSLVLSRVKGDFRTNVae--kdPE 52  Mortierella ver...
Q55EZ9         8 VVLSLYRELIYYSKLIt-----------------------------------nKEEKISKLNLIKSTFKKNKsipeteTE 52  Dictyostelium d...

O43325        59 LIKQCIDECTARIEIGLHYKIPYPR 83  human
XP_003060466 103 LVERYLREGEERLYMANNYKIAYAR 127 Micromonas pusilla CCMP1545
XP_007511486  58 HVQKAIDYAKTRIFYCKNYGIAYER 82  Bathycoccus prasinos
SPR01919      46 EIDAKLFEGNTRVDLALHYGIASPR 70  Plasmodiophora brassicae
NP_001129840  58 VIGKLIYQAEQRIVQAEHYGIPHAR 82  Caenorhabditis elegans
GBF90568      53 EAEARLAEAEQRVDLAIHYAIPYPR 77  Raphidocelis subcapitata
XP_003079011  43 SLEERLAEGERRLALAEHYGIAYSR 67  Ostreococcus tauri
XP_002673867  90 EIKSKIELAEKRLLLTLHYGIPFER 114 Naegleria gruberi strain NEG-M
KFH67759      53 EIEAMIQLAELQVDNLQIQRDHLTE 77  Mortierella verticillata NRRL 6337
Q55EZ9        53 KIDKLIEDGQKKLSFLKIMTPREFA 77  Dictyostelium discoideum AX4
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