4D6K


Conserved Protein Domain Family
DNTTIP1_dimer
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pfam18192: DNTTIP1_dimer 
DNTTIP1 dimerization domain
This is the N-terminal domain of DNTTIP1, a protein that forms part of a novel histone deacetylase complex present in Homo sapiens. Histone deacetylase complexes comprise DNTTIP1, histone deacetylase (HDAC) and the repressor protein MIDEAS. The acetylation of histone tails plays a critical role in determining the accessibility of chromatin to transcriptional regulators and RNA polymerase complexes. This N-terminal domain is responsible for dimerization of histone deacetylase 1(HDAC1). The N-terminal domain also interacts and mediates the assembly of the HDAC1- MIDEAS complex.
Links
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Statistics
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PSSM-Id: 408020
Aligned: 8 rows
Threshold Bit Score: 90.5198
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4D6K_A         10 ISMDLLRAVLQPSINEEIQTVFNKYM-KFFQKAALNVRDNVGEE--------VdAEQLIQEAC-RSCLEQAKLLFSDG 77  
EDV22112      147 RALELLRSTVQYSFNKEIMKLCEENL-MLYEIAAKNIRENTGDN--------I-TRDDIYALI-RKSLDESKRMFEPG 213 
EHB05299       65 ISMDLLRAVLQPSINEEIQTVFNKYM-KFFQKAAMNVRDNVGEE--------VdTEQLIQEAC-RSCLEQAKLLFSDG 132 
XP_002129783   71 SSMDLLLKVLQPAINSDVMEMFHKYI-EVFREGAENAAENMNLEpfksvnrvVdVDALVSRAC-MNALENAKKIFRNK 146 
VDL71101        7 KSLDLMRRIFQNEITKELQQIMDRHIrTTFSPAIENLKKNGH----------VvDQDVINDLY-TSILDAAKVPFMRD 73  
EKC33772     1385 KSLDILRQNIQRFINKEIDVIIQDYMeKFFKPGVRNIKMNNGEN--------SvNEEHVQAVC-RQILEEAKKMYCTD 1453
OWR47393       88 KSLDMLRQTVQSAVTREIDQVIKKYLeKFFVPAVNNIRLNLGDE--------SvSEDQVRAVC-RAMLDATRLLYSTP 156 
XP_002035087  455 RALELLRISVQQAFDAEVNELIKKYMqNYFKPAFGNIKENLGQH--------SvNEETLQKMSsCALLENAKAQYTNF 524
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