3CUE,2J3T,2ZMV


Conserved Protein Domain Family
TRAPPC4_synbindin
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cd14856: TRAPPC4_synbindin 
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Trafficking protein particle complex subunit 4
Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.
Links
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Statistics
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PSSM-Id: 341446
Aligned: 61 rows
Threshold Bit Score: 149.59
Created: 15-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:TRAPPC1 interface [polypeptide binding site]
Evidence:
  • Structure:3CUE; Saccharomyces cerevisiae TRAPP complex, contacts 4A
  • Structure:2J3T; Human TRAPP I complex, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #  #                                                                            
3CUE_A      4 ETILVINKSGGLIYQRNftndeq--------------------------------------------------------- 26  baker's yeast
ETO16490    4 HSLLILSRSGLLVFCKDfvkhpr--------------------------------------------------------- 26  Reticulomyxa filosa
EAL46160    6 YSVIIINKTGTLQWMRDfsekpt--------------------------------------------------------- 28  Entamoeba histolyt...
EFV55521    4 FYIFIINRAGSLIFDCDycprgvdieisfnypidiklqlidsrptvafgerngvnvgyivtevngrpvgsggrvesapgt 83  Trichinella spiralis
CCD68600    6 QHLFIINRAGSLIYSWEartetpevektyewpidvhleevdqkavvvfgekdgiklryyvks--vngetvsgtrlqlgaq 83  Caenorhabditis ele...
CAA15613    2 YSLYVNNQHGTLVYQKHfseeik--------------------------------------------------------- 24  Plasmodium falcipa...
EAN31920    2 LSLFMINKHGCLIYYKClsgndt--------------------------------------------------------- 24  Theileria parva st...
CCD60759    4 YGLYVISESGSLQFYYDhsdvnvevekkydfplpfhfkavdgrivvdfgacddvkigytvi-----svdgitakgtsled 78  Schistosoma mansoni
EER05036   31 FALYIVSRDGSLLYDYEsltaeq--------------------------------------------------------- 53  Perkinsus marinus ...
EFO65362    2 QQVYLINSSGSLMYSYStikdl---------------------------------------------------------- 23  Giardia lamblia P15

Feature 1                                    ##  ##  #  ########                              
3CUE_A     27 -----------------------klnsneYLILASTLHGVFAIASQLTPKalqltqqtnientipyipyvgmssnrsdtr 83  baker's yeast
ETO16490   27 ------------------------lkpndWIRVTGIFHGMSEVIKQLSPLpt---------------------------- 54  Reticulomyxa filosa
EAL46160   29 -----------------------krtendPLYLASSFHGFSVVASQINPLlk---------------------------- 57  Entamoeba histolyt...
EFV55521   84 ffnlfdylsdpnnfplmmkfskpgltaneKIILSSMFHSFHAIGAQLSPClg---------------------------- 135 Trichinella spiralis
CCD68600   84 qvnvleylqeedhypvtvkfaaptvstneKIILSSMFHSLFTIAVQLSPCqk---------------------------- 135 Caenorhabditis ele...
CAA15613   25 ------------------------lnsneEIRLASMLHGISTISEKINVYslyekktn---------------------- 58  Plasmodium falcipa...
EAN31920   25 ------------------------lnsndIIRLASTLHGLSTISIKLCSNnhnns------------------------- 55  Theileria parva st...
CCD60759   79 nrdilkvfsdkdnfpltiklgrprlrpndRIHLASMFHPLHSMARLLSPIpdssfsfvspa------------------- 139 Schistosoma mansoni
EER05036   54 -----------------------rpsandKIRWSSTFHTLSAIAASLSPTlpasghgsagg------------------- 91  Perkinsus marinus ...
EFO65362   24 -------------------------dsndHITLASTYFSLSTMSNECSPRep---------------------------- 50  Giardia lamblia P15

Feature 1                                      ########  # #             #                    
3CUE_A     84 ngggnnnkhtnneklgsfkgddffkepftnwnkSGLRQLCTdqFTMFIYQTLTGLKFVAISSsvmpqrqptiattdkpdr 163 baker's yeast
ETO16490   55 -------------------------------knDGISSVEDetFRLHCYQTLTGLKFIVTATpt---------------- 87  Reticulomyxa filosa
EAL46160   58 -------------------------------esDGIQKIQTsnFSLQCLHTQTGVEFLVIASpqs--------------- 91  Entamoeba histolyt...
EFV55521  136 --------------------------------sGGICQLITdtFRLQCFQSHTGLKFLAICDlc---------------- 167 Trichinella spiralis
CCD68600  136 --------------------------------sSGVEVLETtqFKLFCLQSRTGVKFVVITSaas--------------- 168 Caenorhabditis ele...
CAA15613   59 --------------------------ifqslekKGIETIEGdgFKIQCYDTLTGIKIFIVHKddl--------------- 97  Plasmodium falcipa...
EAN31920   56 ----------------------------iipspKGITNIDSdyFRLQCLETLTGTDLRLCIFmicdln------------ 95  Theileria parva st...
CCD60759  140 -----------------------ndkkaprvwnSGIQTLETecCRVHCFETHTGVKFLLVTDvkl--------------- 181 Schistosoma mansoni
EER05036   92 -----------------------ggsrlgylnpRGIKTIRGaaYSVHCMTVISGTKAFAVCApsf--------------- 133 Perkinsus marinus ...
EFO65362   51 -------------------------------ctSGLREIRTttGSIACLETPTGIRLIAAAAkhi--------------- 84  Giardia lamblia P15

Feature 1                                                        
3CUE_A    164 pkstsnlaiqIADNFLRKVYCLYSDYVMKDPSYsmeMPIRSNLFDEKVKKM 214 baker's yeast
ETO16490   88 --------teNLERLLKDVYGLYCDFVMKDPFHkmeQPIKSHKFIEQLDTL 130 Reticulomyxa filosa
EAL46160   92 --------apVLGEFLSQLYILYTDYVLKNPFIiseMIIKSKKFETKVREL 134 Entamoeba histolytica HM-1:IMSS
EFV55521  168 --------tgDLEPLLHRLYELYSDYALKNPFYsldMPIRCELFDQASIAN 210 Trichinella spiralis
CCD68600  169 --------niAADSLLSKMYELYTDFALKNPFYsidMPIRAQKFDEAIKTL 211 Caenorhabditis elegans
CAA15613   98 --------niEMNTYLKRVYELYSDIILKNPFYdidMPIRSAVFNEQIEKL 140 Plasmodium falciparum 3D7
EAN31920   96 -----gpskgHLNVMLSYIYELYSDYVQKCPFHkvdMPIRSKLFDEQINSY 141 Theileria parva strain Muguga
CCD60759  182 --------pmASREALRRVYEAYTDFVLKNPFYarnQPFNYEFFANQIKTI 224 Schistosoma mansoni
EER05036  134 -------pesVAQELLAQIFFYFCDYVMKNPFYelgMPARCKQFDDRVQQL 177 Perkinsus marinus ATCC 50983
EFO65362   85 -------sivRLHQFLRDLYRLYADFVVKNPFFvpnQLIRATKFEKGVQKL 128 Giardia lamblia P15

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