586408 1 MARRKNFKKGNKKTFGARDDSRAQKNWSELVKENEKWEKYYKTLALFPe---------dQWEEFKKTCQAPLPLTFRITG 71 baker's yeast 19074454 16 IEMVRHVLEGRSTVKQEVYKMKDPKMYHKLVHMVVENHDLLLDLIKRCky--------mEDDRELGVIRCFQILDRRIRN 87 Encephalitozoon cun... 14521973 34 VEHYYIRVNTLKVSREKLIEELRK--EGLKPRRSPYLQEALYFVREGPnfs------deYNPDLPTVIANKYAAESVYQG 105 Pyrococcus abyssi 18312148 36 PPRYYIRVNTLKISPRELVKRLNSRGLAVYRDEYIDDALWVPVEGPFKi-----------pTAKKVVVVDKKAAESVMLG 104 Pyrobaculum aerophilum 18314169 73 MKAVAKAWFIYRADALLYNKDLVTRYKKRLLKRALARPEEALEQLEGLrdn------avEYLSVKYSYHPKIVSTLLSHL 146 Pyrobaculum aerophilum 14591725 37 VEHYYIRVNTLKISREKLIGELKK--EGLKPLRSPYLPEGLYFVREGPnfs------ddFEPKLPVVVANKYAAESVYQG 108 Pyrococcus horikoshii 19115421 48 pVLDEIIARSDCFLKENLARVLVHDLLMSK-RGLSISNGPIKECILRHk-----------TRLNAEFVKLKVKKGVKSHe 115 fission yeast 15897082 17 qKNYPLAIAFKRAYLHNKPRKIDSNLLYEYSKRLILSYYALPQSKRSAkvrywlknrenIEIKFPKWMEDKLFTLLDVN- 95 Sulfolobus solfatar... 15897306 8 NPRLYIRVNTLKTSVEKILERLPHFKPDEDFKEAIYVEIKGPNEINIHe---------------nKVIVDKKTAESAMLG 72 Sulfolobus solfatar... 1730712 83 FSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLkl--------kVRELSELVLSEDISNDLPPVR 154 baker's yeast
586408 72 --S-RKHAGEVLNLF-KERHLPNLTNVEFEGEKIKAPVELPWYPDhl------aWQLDVPKTVIRKNEQFAKTqrflvvE 141 baker's yeast 19074454 88 trMrRKFMKALGGRKlKLTKATVFVRINTLRGGTEEDIGFLDYEKs---------CVDGVYKILDSKNIVFSEg------ 152 Encephalitozoon cun... 14521973 106 --AmLYAPGVLRADK-GIKEGDEVQIRDPRGLLVGIGIARMDYKEm--------IEATRGLAVEVTLPKFKLPslselkS 174 Pyrococcus abyssi 18312148 105 --AdLYAPAVIKTDR-VNIGDEVNIVSDNGRVVALGVAVMDSDEA---------LKARRGLYIKVEKSLYRTPklrnlpE 172 Pyrobaculum aerophilum 18314169 147 pqGeVERLLEAGNATwIWLRINTLKADIDKALRILEAEAEVEPHP---------KIPFVVLLKNAKRPVQYLE------A 211 Pyrobaculum aerophilum 14591725 109 --AmLYAPGVLKADK-NIKEGDEVQIRDPKGLLVGIGIARMDYKEm--------TEATRGLAVEVTLPKFKLPslselkA 177 Pyrococcus horikoshii 19115421 116 ----ELALKNPVSLP-RWLRINTIKSTKDEVLQGLGLDKVSSIEElgpdkfyidDCVENLIAIDPSFPIVENS------L 184 fission yeast 15897082 96 ----ALKRKLTERWI--WARINLLKTDIDKVYRMLESQNIEFEPDk--------DFYYMIKINRSSVRLSSLS------I 155 Sulfolobus solfatar... 15897306 73 --AnVYKPGLKSVVI-NNAKDKRVTVYSDNGIPVAEGKYYGMNTN---------LVVEVTNSLYTSPKLADLP------E 134 Sulfolobus solfatar... 1730712 155 --WiRINPLKCHPNGeTEPVLAELRKKFTLKVDKWSELVPGSIYYd--------EFIPNLFGIHPSDKITAHE------L 218 baker's yeast
586408 142 NAVGNISRQEAVSMIPpIVLEVKPH--HTVLDMCAAPGSKTAQLIEALHKDTDEps-gfVVANDADARRSHMLVHQLKRL 218 baker's yeast 19074454 153 YKNGKFVIQNISSCLPahILDPEEG--SRVIDTCSAPGNKTSQLAMIMRNTGKI------YAFERSKNRAETLRAQLFKL 224 Encephalitozoon cun... 14521973 175 FEKGYFYPQSLPSMVAtRVLEPKED--ELIIDMAAAPGGKTTHIAQLLQNRGEI------IAIDKSKNRLKKMEENLRRL 246 Pyrococcus abyssi 18312148 173 YAEGLFYSQSLPAILVg-HIARRITq-TDAVDLNSAPGGKTTHLAQMGIR---------VIAVDRSAQKIEKLRSEAARL 241 Pyrobaculum aerophilum 18314169 212 VKRFLAIPQDLASIYAvlSLNPQPG--DRIIDLAAAPGMKTSLIAQLAEGRAKI------VAVDLSAKRVSRMRHLLKNL 283 Pyrobaculum aerophilum 14591725 178 FEKGYFYPQGLPSMVTaRVLEPKED--DVIIDMAAAPGGKTTHIAQLLENKGEI------IAIDKSKNRLRKMEENIKRL 249 Pyrococcus horikoshii 19115421 185 YKEGKVIIQDKASCFPaaVLAGLTGhvGDIIDGCAAPGNKTTHLAACFPK-SHI------FAFERDAKRVQTLRKMVGIS 257 fission yeast 15897082 156 VKDFKLILHDKASSIVveALKPEIS--EKLVDLSSAPGIKASLYMMLTENRAET------FLADVDLKRLSKEYNLLKRC 227 Sulfolobus solfatar... 15897306 135 LKNGLIYVQGKASMYVahLLDPHPN--EKIVDMTAYAGGKLTHIYQLEPR--VK-----LIGFDHTEKKVEKLRDLANKM 205 Sulfolobus solfatar... 1730712 219 YKHGKIIIQDRASCFPahILNPGPS--DIVIDSCSAPGNKTTHTASYIYPEPPKdnntrIYAFEKDPERAKVLQKMIKIA 296 baker's yeast
586408 219 NSAN-LMVVNHDAQFFPRIRLHGNsnnkndvlKFDRILCDVPCSGDGTMRKNVNVWKDWNTQ------------------ 279 baker's yeast 19074454 225 GVSN--TEVVEDDFMNANPEDFEG---------IRYILCDPSCSGSGMH----LG-YKMDKE------------------ 270 Encephalitozoon cun... 14521973 247 GVKN-VKLIQMDAR----NLPDLGl-------KADKILLDAPCTALGVR---PKLWEERTPK------------------ 293 Pyrococcus abyssi 18312148 242 GLDV-FIDILLHDSRYLDRDFPKI--------KAGVALVDPPCTDIGVR---PKIYHKVTFE------------------ 291 Pyrobaculum aerophilum 18314169 284 GAGGfVEVVRADSRALKTRR-------------FDKALLDAPCTSSGAFTKEPAVKIYPRLE------------------ 332 Pyrobaculum aerophilum 14591725 250 GVKN-VKLVQMDAR----KLPDLGi-------KADKILLDAPCTALGVR---PKLWEERTLK------------------ 296 Pyrococcus horikoshii 19115421 258 GANN-VTIEHQDFTLTDPKSDLYR--------NVTHILLDPSCSGSGIVSRQDYLLGNEQDVted--------------- 313 fission yeast 15897082 228 GVDLrKVHIIYQDSTKNSIIK------------SDKILLDAPCSSSGMINNDPSILLKLRNGe----------------- 278 Sulfolobus solfatar... 15897306 206 GMR--IEIYKADSRYLYEDYKIGD---------VDKVVIDPPCSALGIR---PKLYDHKTKQ------------------ 253 Sulfolobus solfatar... 1730712 297 GCSPnISVNVGDFTKLATPEKYKD---------VTCFIVDPSCSGSGIFGRKFFDSFNRRKIddkdddggivpdeqeefi 367 baker's yeast
586408 280 -------AGLGLHAVQLNILNRGLHLLKNNGRLVYSTCSLNPIENEAVVAEALRKWGD--KIRL-VN-----------CD 338 baker's yeast 19074454 271 -------RIEGLKSFQIEIVRHALRFR--PEKLVYSVCSDHREEGEEVVEEILRSSEYelENISmFWs------------ 329 Encephalitozoon cun... 14521973 294 -------HIEATARYQRAFIWAAIKSLRKGGVLVYSTCTLSYEENEGNVKFMLKKGMKleDQQIfIG-----------SP 355 Pyrococcus abyssi 18312148 292 -------AAKTLARYQIQFLKTALKIA---PYVIYSTCTLTYIENEGVIEKAGAEIVDagIEIGaPG-----------WG 350 Pyrobaculum aerophilum 18314169 333 -------DAPKYSKLQKALLKNALSLA---SEVVYAVCSILPEEGEEVVTSVGAKAEKplGDLAsSY------------- 389 Pyrobaculum aerophilum 14591725 297 -------HIEATARYQRAFIWAAIKSLRRGGVLVYSTCTLSYEENEGNVKFMIRKGMKleEQSIfIG-----------SP 358 Pyrococcus horikoshii 19115421 314 -----teRLENLCSFQSTILKHALQFP-NCRHVTYSTCSVHRLENEQVVCEVLSQEPDwkCNSLtKTlp--------nWK 379 fission yeast 15897082 279 -------KIEKFTKLQKSLLNEALKIK--SNKLVYAVCSLFPEEGEKVIEDYYEIAEKp-FSNYqSG-----------YS 337 Sulfolobus solfatar... 15897306 254 -------DILNFHKYQKQFLNSAYKILKKNGVVIYSTCTVTTWENEKVINDPR-------FS------------------ 301 Sulfolobus solfatar... 1730712 368 akeelqtRLAKLSSFQFQMVKHAMSFP-AAKKIVYSTCSIHAEENERVVIDLLLDKSVreWGWKvAPkrevipswprrGK 446 baker's yeast
586408 339 d------KLPGLIr---SKG---VSKWPVYDrN-LTEKTKGDEGTL 371 baker's yeast 19074454 330 --------SAHSSg--fSFSqdvVRCRRDES-GaIGFFIALFVRKK 364 Encephalitozoon cuniculi 14521973 356 g----------------iGLdkvQRFYPHKHnT-QGFFIAKLRKVR 384 Pyrococcus abyssi 18312148 351 cr-------------------ecRRFLPHVHnT-PGFFIAVLRGAR 376 Pyrobaculum aerophilum 18314169 390 ------------------RGevgGRTFPHVH-KsEAFFISRLRE-- 414 Pyrobaculum aerophilum 14591725 359 g----------------iGMnkvQRFYPHKHlT-QGFFIAKLRKVK 387 Pyrococcus horikoshii 19115421 380 t-----rGIPEYCaq-pSMAegmIRCKPGAG-GtIGFFVANLYHPQ 418 fission yeast 15897082 338 lf---------------kSGkrsNRTFPHID-StEGFFISTLNLTK 367 Sulfolobus solfataricus 15897306 302 -------------------VeyeIRFHPHIH-EiTGFFIAKLIKKG 327 Sulfolobus solfataricus 1730712 447 veefeevFRDGVTydpqQLAegcIRALPKSD-GgIGFFAVCFERD- 490 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",