1A0P,1Q3V,1Z1G


Conserved Protein Domain Family
Phage_integrase
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pfam00589: Phage_integrase 
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Phage integrase family
Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.
Links
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Statistics
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PSSM-Id: 395471
Aligned: 24 rows
Threshold Bit Score: 115.495
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1A0P_A 110 DLSEAQVERLLQAPLIdq---pLELRDKAMLEVLYATGLRVSELVGLTMSD-ISLRQGVVRV---IGKGNKERLVPLG-- 180 Escherichia coli
P0ADH5  12 FLTHSEIESLLKAANTg----pHAARNYCLTLLCFIHGFRASEICRLRISD-IDLKAKCIYIh--RLKKGFSTTHPLL-- 82  Escherichia coli K-12
P0ADH7   6 YLTGKEVQAMMQAVCYg----aTGARDYCLILLAYRHGMRISELLDLHYQD-LDLNEGRINIr--RLKNGFSTVHPLR-- 76  Escherichia coli K-12
P45198 135 RVTEENINAIVAISEYvdtlktAKARTAAAILFAVETAMRAGKICSLSWGN-VNFEKRTAFLp--MTKNGTSRTVPLTkn 211 Haemophilus influenza...
1Z1G_B 179 RLTADEYLKIYQAAES------SPCWLRLAXELAVVTGQRVGDLCEXKWSD-I--VDGYLYVe--QSKTGVKIAIPTAlh 247 Escherichia virus Lambda
Q32DW2 173 RLTANEYVEIYHAAEP------LPIWLRLAMDLAVITGQRVGDLCRMKWSD-I--NDNHLHIe--QGKTGAKLAIPLTlt 241 Shigella dysenteriae ...
P32053 213 SIRPDQLPQLMHTMRTa----sISMSTRCLFMWQLLTITRPAEAAEARWDE-IDFNASEWKIpaaRMKMNRDHTVPLSdg 287 Escherichia coli K-12
P37326 199 FLPADQIPAFNKALATf----sGSIVSLIATKVLRYTALRTKELRSMLWKN-VDFENRIITIdasVMKGRKIHVVPMS-- 271 Escherichia coli K-12
Q5HNP3 330 FIDEFVLEQLNSHLDK------LPEYIATMTMIVQECGMRISELCTLKKGClLEDKDGDFFLkyyQWKMKKEHIVPIS-- 401 Staphylococcus epider...
P42540 106 RFYHDDLELIMTYTKNlns-skNSITYKSFIRLLLDSGLRVSEALNIKISD-MDFKNKVIRVl--SSKTRKQRYAPFS-- 179 Acholeplasma virus L2

1A0P_A 181 -EEAVYWLETYLEHGrpwLLNGVSIDVLFPSQ--RAQQMTRQTFWHRIKHYAVLAGIDs-----EKLSPHVLRHAFATHL 252 Escherichia coli
P0ADH5  83 -NKEVQALKNWLSIRt--SYPHAESEWVFLSR--KGNPLSRQQFYHIISTSGGNAGLS------LEIHPHMLRHSCGFAL 151 Escherichia coli K-12
P0ADH7  77 -FDEREAVERWTQERa-nWKGADRTDAIFISR--RGSRLSRQQAYRIIRDAGIEAGTV------TQTHPHMLRHACGYEL 146 Escherichia coli K-12
P45198 212 aIAILERLKVEIGDA----------GLCFDIK--------SSVLDATFRKLKKLAERE-------YLHFHDTRREALTRL 266 Haemophilus influenza...
1Z1G_B 248 iDALGISXKETLDKC----KEILGGETIIAST--RREPLSSGTVSRYFXRARKASGLSfe---gDPPTFHELR-SLSARL 317 Escherichia virus Lambda
Q32DW2 242 iDALNISLVDTLQKC----REASSSETIIASK--HHDPLSPKTVSKYFTKARNASGLSfd---gDPPTFHELR-SLSARL 311 Shigella dysenteriae ...
P32053 288 aLAILEMMKPLSGGR----------EFIFPSRikPNQPMNSQTVNAALKRAGLG----------GVLVSHGLRSIASTAL 347 Escherichia coli K-12
P37326 272 -DQVVELLTTLSSIT------KPVSEFVFAGRndKKKPICENAVLLVIKQIGYE-GLE---------SGHGFRHEFSTIM 334 Escherichia coli K-12
Q5HNP3 402 -KEVALLIKVREDKV---SEEFPDSEYLFPRK--DGSPLKQETFRGELNKLAYEQNIVdksgeiYRFHAHAFRHTVGTRM 475 Staphylococcus epider...
P42540 180 -SFSLKYIKELIEVN-------PKRDYLFYNFi-KDRQTNKNDIKLFYKRLKKHLNLE-------RIHTHRFRKTFASIL 243 Acholeplasma virus L2

1A0P_A 253 LNHGADLRVVQMLLGHSDLSTT-QIYTHVAT 282 Escherichia coli
P0ADH5 152 ANMGIDTRLIQDYLGHRNIRHT-VWYTASNA 181 Escherichia coli K-12
P0ADH7 147 AERGADTRLIQDYLGHRNIRHT-VRYTASNA 176 Escherichia coli K-12
P45198 267 SKKV-DVMTLAKISGHKDISILqNVYYAPDM 296 Haemophilus influenzae Rd KW20
1Z1G_B 318 YEKQISDKFAQHLLGHKSDTXA-SQFRDDrg 347 Escherichia virus Lambda
Q32DW2 312 YRNQIGDKFAQRLLGHKSDSMA-ARYRDSRg 341 Shigella dysenteriae Sd197
P32053 348 NEEGFPPDVIEAALAHVDKNEVrRAYNRSDY 378 Escherichia coli K-12
P37326 335 NEHEWPADAIEVQLAHANGGSVrGIYNHAQY 365 Escherichia coli K-12
Q5HNP3 476 INNGMPQHIVQKFLGHESPEMT-SRYAHIFD 505 Staphylococcus epidermidis RP62A
P42540 244 IENGLNIDDLQKIFDHSRIETT-IKYVQHNE 273 Acholeplasma virus L2
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