Conserved Protein Domain Family
Sprouty
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pfam05210: Sprouty (this model, PSSM-Id:398746 is obsolete and has been replaced by 461589)
Sprouty protein (Spry)
This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.
Links
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Statistics
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PSSM-Id: 398746
Aligned: 45 rows
Threshold Bit Score: 61.9609
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX84664     356 RVRCKHCqdtyRPEENYRGA----------CDhapdcVRSTIDAVSCVSCAECLMYHCYadAEGD-FAP--QPCVcgsgs 422 common water flea
3_pfamImport   1 KCRCDSC----RSPRSPPSAwlcs--dlcyCS-----VDSCVDYASCLCCVKGAMYHCG----EE-PGWadDPCS----- 59 
EEN67677     267 RCICPDC----AEKKIESTNdatcg-nrlmCT-----SEDALDYATCMCCVKGVFYHCSkdNCDDdFRSadNPCS----- 331 Florida lancelet
NP_001163980 152 RCKCNEC----AQVRNLPSCwvcn--drciCS-----AENVIDYGTCLCCIKGLFYHCS--TDDE-DNCadDPCS----- 212 tropical clawed...
XP_014343108 158 RCKCNDC----TAPRSLPSRwicd--qrclCS-----PENVLDYGTCLCCIKGLFYHCS--SDDE-DNCadDPCS----- 218 coelacanth
XP_005342132 152 RCKCVPC----TAARPLPSCwlcn--qrclCS-----AESLLDYGTCLCCVKGLFYHCS--TDDE-DNCadEPCS----- 212 thirteen-lined ...
XP_007244508 148 RCKCQEC----CAPRSLPSCwacg--qrclCS-----AENAVEYGTCLCCVKGLFYHCS--ADDE-DNCadRPCS----- 208 Mexican tetra
ESN92576     615 RCRCDSC----TRPKRLPRTwlgsarcrfeCS-----AEEAVRVCSCLCFIQAFFYHCFyhPDDDdDYLmtEPCAc---- 681 Helobdella robusta
EKC37112     108 KCKCGSC----TEPKKLPQRwccg--dycqVS-----PDCIVDTCTCFCCVKAVFYHCGkdQDDDeDMCymHPCAg---- 172 Pacific oyster
XP_011616558 206 RCRCPEC----SRPRTLPSCwmcg--rrcvCS-----AQSAVEYITCVCCVKGLFYHCS--SDDE-DTCadKPFS----- 266 torafugu

EFX84664     423 vrrhngsgCCSiESSPKRWFGLALLSLVVPCLWCYLPLRACYRCGVRCGC--------C 473 common water flea
3_pfamImport  60 --------CSG-AGWGPRWACLSIASLILPCLWCYCPLRSAADACSRGYAacthrgctC 109
EEN67677     332 --------CSR-KHCFLRWTALGLMGMFLPCLLCYLPVRGCMRLTTACNHrehkkgclC 381 Florida lancelet
NP_001163980 213 --------CSQ-GSCCARWAAMSLLSFFMPCLCCYLPAKGCLKLCQKAYDrvkrpgcrC 262 tropical clawed frog
XP_014343108 219 --------CNQgGQCCSRWAAISFFSVLMPCLCCYLPAKGCLKLCQKCYDgikrpgcrC 269 coelacanth
XP_005342132 213 --------CGP-SSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDslrrpgcrC 262 thirteen-lined ground squirrel
XP_007244508 209 --------CAP-AHACARWGTMALLALCLPCLCCYPPAKLCLTLCQRGYDrtk--rpgC 256 Mexican tetra
ESN92576     682 --------CER-PRCCLRWGLMTLLTPILPCLCCYCPLQCCVDSLTACYDsctnegcrC 731 Helobdella robusta
EKC37112     173 --------CTK-PHCVKRWTCMAMMACCLPCLCCYWPARAVLKACTSCYNkcrkkgcqC 222 Pacific oyster
XP_011616558 267 --------CRQ-SHCCVRWSAVSLLSLLFPCLLCYLPAKGCVAVCQSCYD--------R 308 torafugu
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