5A9Q


Conserved Protein Domain Family
Nup96

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pfam12110: Nup96 
Nuclear protein 96
Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex.
Statistics
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PSSM-Id: 463462
Aligned: 121 rows
Threshold Bit Score: 174.705
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A9Q_5              452 EAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADS-FIQDERLRIFALLAGKPvwql 530 
XP_028038292       1373 ARIWTLLLGGRTLEACKLARESGDLNMAMLLAQAGGDVAYRGLVARQLAQWSACGADT-HVAGARLHALRALGGAAppa- 1450
XP_001750473       2354 QNVLRALLVHDLESAASLASSQKDHHLSLLIAQAGGANKMRSWLLNQLQDWQQRAADD-FIHPLRLRIYAVLAGAMiwpd 2432
XP_001565807        615 EELVQAILCHRLREARTSARSVANEELARVVRVCGEGNQFGGYVEMARSGFRNGEEVR-------QRVVSLLSGKVepfi 687 
EEF35071            602 EHILLLMTGRQLDGAVEIAVSRGDVRLACLLGQAGGSMVNRTDVARQLDLWRNNGLDFnFIEKERIRLYELVSGNIhnal 681 
KRH14081            556 QHIFVLLTGRQLDEAVQLAVSKGDVRLACLLSQAGGSTVNRSDIARQLDIWRNKGLDFsFIEKDRLRLYELLAGNIhdal 635 
Q8LLD0              579 EHLFFLLTGRELDSAVELAISKGDVRLACLLSQAGGSTVNRNDILQQLHLWRRNGLDFnFIEKERIKLYELLAGNIhdal 658  thale c...
WGS:AAAA:OsI_10206  542 EHIILLLTGRQLDTATEVAASRGDVRLAILLSQAGGSMLNRSDLSQQLDLWKTNGLDFdYIQEDRLKIYELLSGNVqgal 621 
XP_003061415        254 NAAAAHAAAGRSSRSVASAAANRDPRLATLLAQANAGGDLRALTAAQLDLWRGSPVEK-YLTRETSSAFALLAGEVs--- 329 
XP_001420436        128 RAALTHVAGGRTVSAARAAAAHGDPRLATCLAQIGAGKNVAFYAKQQLTRWRAGSVGK-YIDEFSEQAFKLLAGEVerd- 205 
5A9Q_5              531 sek---kqinvcsQLD-------WKRSLAIHLWYLLPPTASISRALSMYEE-A--FQntsdSDRYA-----------CS- 585 
XP_028038292       1451 -----------laGAG-------WLRALHATARYICPQIPSLEKIIRTYEG-F--FS----KDEQVdltslgddvdmRP- 1504
XP_001750473       2433 qaq---trlptcqGLP-------WLAALAVHHWYAVSSTATVADSIRSYARsAfnLL----SGRSK------------Sg 2486
XP_001565807        688 rdeeytglhdeaiEVRaaptaatWKQLLGIFTFYGCVSDTPAEDIIHAFLE-R--LR----APSSRk----------LN- 749 
EEF35071            682 ----------dgvKID-------WKRFLGLLMWYRLAPQTSLPIIFQTYQH-L--LN----DGKAP------------Y- 724 
KRH14081            636 ----------hdvKID-------WRRFLGLLMWYKLPPNTSLPIAFQTYKH-F--VD----EGTAP------------Y- 678 
Q8LLD0              659 ----------qdfTID-------WKRFLGLLMWHHLPPDSSLPIIFRSYQL-L--LN----QAKAP------------W- 701  thale c...
WGS:AAAA:OsI_10206  622 ----------vdsSID-------WKRYLGLIMWYQLSPDASLDIIIHSYHQ-L--LG----EGKVP------------Y- 664 
XP_003061415        330 ------------pPEDvvrgvgaWPQNFGLTQWFASPPTTTLSAVVEGYLE-A--VA----RGEAA------------Y- 377 
XP_001420436        206 -----------ddGMG-------WYQNLGLHMWLAAGPTSPLRDVVKNYLD-A--VA----QQRAA------------N- 247 
5A9Q_5              586 ----------PLPSYLEGSGCVIAEEQNSQTPLr-------------DVCFHLLKlys--------drHYDLNQ--LLEP 632 
XP_028038292       1505 ----------PLPDYNEDYCYITSKNGNTKAVL--------------DLRYELIR-------------ARAFNQrpKLKP 1547
XP_001750473       2487 aavqtfeaaaPSPSYLDPEALQAQQMLGMQKFDdasgmpssnsdffgDLLFNIMQmfa-------cpsNVNMER--ALLG 2557
XP_001565807        750 ----------PLPPYAERVDTAVLRTCRGKDVVrrgn-------tfqDAALLVLEgfa--------ngSAPPAA--CLHP 802 
EEF35071            725 ----------PLPIYIDEGPAEEAVNFS-GRHF--------------DLSYYLMLlhak-----gdgeIGYLKT--MFSA 772 
KRH14081            679 ----------PVPLFIDEGTSEEVISWNTDNHF--------------DISFYLMLlhan-----eetkFSFLKA--MFSA 727 
Q8LLD0              702 ----------PVPIYIDEGPADGFVSDN--KHS--------------DILYYLMLlhsk-----eeeeFGFLQT--MFSA 748  thale c...
WGS:AAAA:OsI_10206  665 ----------PVPVYIDEGPLDESLQWSPGDRF--------------DISFYLMLlhan-----qdekFGMLKT--MFSA 713 
XP_003061415        378 ----------PDA---PGLIAVDADARRLK-----------------DASFNLLIlgskg---ptapsDADVRD--AFHP 422 
XP_001420436        248 ----------PLP---PVATYEALDANQATHLR--------------DVAFNILAlaastedeggspsTAEVRV--AFHP 298 
5A9Q_5              633 RSI-TADPLDYRLSWHLWEVLRalnyt--hlsaQCE-----GVLQASYAGQLESE--------------G--LWEWAIFV 688 
XP_028038292       1548 AAY-TPDPNDFTLCFLLGAWFG-----------SPA-----VESVVSVAEQLEAG--------------G--AWQLATAV 1594
XP_001750473       2558 RTV-GPDLDDLRLPCLAYLILRslgap--qlnaHAE-----AQLLTDFAAQLEGA--------------G--AWCHAVFV 2613
XP_001565807        803 HAS-SYSGTDYLTAFVIVTAIRavqlprdqayrDAE-----LSVLLGMTAELECNd---------------eTWFWGLLP 861 
EEF35071            773 FSS-TNDPLDYHMIWHQRAILEavgi----ltsNNL-----QVLDIGLVSQLLCI--------------G--QCHWAIYV 826 
KRH14081            728 FSS-TPDPLDYHMIWHQRAVLEavgv----insNDL-----HILDMSFVSQLLCV--------------G--KCHWALYV 781 
Q8LLD0              749 FSS-TDDPLDYHMIWHHRGILEavga----ftsDDL-----HTLDMGFVAQLLSQ--------------G--LCHWAIYV 802  thale c...
WGS:AAAA:OsI_10206  714 FSS-SYDPLDYHMIWHQCSILEaiga----fssNDL-----HVLDLSFVYQLLCL--------------G--KCHWAIYV 767 
XP_003061415        423 LTYcARDLGNVSLAWHLFATLRaiga----lpeTVEnralgDALHANFARQLLSSssssssetktrrqqRhsMIEWAVFV 498 
XP_001420436        299 LTY-SDDVLNASLAWHLFGVLNaigvlegegmdALA-----DEITVAFATQLLGMpe-----------rG--RCEWAVFV 359 
5A9Q_5              689 LLHID--NSGI--REKAVRELLTRHCQLle------tpESwaKETFL--TQKLRVPAKWIHEAKAVR 743 
XP_028038292       1595 LAYHP--HGAA--RSSLVRSMISRHAPS----------SG--SAPGLqlLERIGVPEKWIHLARAHR 1645
XP_001750473       2614 LLHLR--DDVP--RTHAARTLVLRHLTAec-------rEA--ERDFL--KVELKVPETWLHEALAQD 2665
XP_001565807        862 LHMIE--SPTN--RLDAVRAFCKRNAMRasaqkqlgeaQP--DYNRL--MCLMHVNEGWLEPAVAPP 920 
EEF35071            827 VLHMPyrDDYPylQATVIREILFQYCEIws------ldES--QRQFI--E-NLDIPRAWLHEAMAVN 882 
KRH14081            782 VLHLPlrEDYPylHVNLIREILFQYCETws------sdES--QQQFI--E-DLGIPTDWMHEALAIY 837 
Q8LLD0              803 VLHIPfrEDHPylHVTVIREILFQYCETws------smES--QRQFI--K-DLGIPSEWMHEALAVY 858  thale cress
WGS:AAAA:OsI_10206  768 ILHMPhlDDAPyiHEKLIREILSQYCESws------kdET--QRVYI--A-ELGIPVEWMHDALALY 823 
XP_003061415        499 AMHVE--DGAR--RRDLVKEILNAGCAEwc------ddDA--KTTFM--RETLRVPEAWTREAKETW 551 
XP_001420436        360 SQHLR--DDTR--RTKMTGHILRERFEEwk------cdDG--KIAFI--KDVCAVPQESLDDAHALW 412 
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