1ZC6


Conserved Protein Domain Family
ASKHA_NBD_GspK-like
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cd24082: ASKHA_NBD_GspK-like 
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins
The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.
Links
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Statistics
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PSSM-Id: 466932
Aligned: 85 rows
Threshold Bit Score: 126.491
Created: 27-Jun-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1ZC6; Chromobacterium violaceum N-acetylglucosamine kinase forms a homodimer, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1ZC6_A        12 YLIGVDGGGTGTRIRLHas-dGTPLAXAEGGasalsqGIAKSWQAVLSTLEAAFQQAglpa---apasACAIGLGLSGvh 87  Chromobacterium...
TAN12650      11 HLIAIDGGGTGCRALVAtm-gGVVLGRGASGsanlmtDPEGTCRSVVEAVEAAFADAglpa---gamrRSGAFLGLAGan 86  Rhizobiaceae ba...
KPB01596       7 FYLGVDGGGTGCRACLCda-dGVPLSFAKAGsanimsSLDVARDSILQCCSEAVEQIglpa---eklsQIPVYMGLAGae 82  Ahrensia marina
PCJ03353       8 LIIAIDGGGSTCRVNICql-dGIVLGAAVGGaanlttDFTAAVATILATIGTAYKSAnlsp---dckpNDYAYLGLAGak 83  OCS116 cluster ...
RPG55191       3 YFVGVDGGGSGCRVVLTsa-kGTILSRASGGpanietSFVAAKENIIESCKLALNLAkipk---eeisNCHAVLGLAGsn 78  Flavobacteriale...
PCJ89467       8 YLVGVDGGGTSCRVAVSdv-sGTVLGRGMSGasnvtsDFEGAIANINLAVDNAFTEAgian---wshgQVSAVLGLAGvn 83  Hyphomicrobiale...
WP_133572992   7 CVLLIDGGGSGARARLCtl-sGEVLATGTAGpsnistDFEAAAANLMGLAHAVYAQAgrdi---tsfaNDYAFVALAGag 82  Maritalea mobilis
RZO33024      13 HILAIDGGGTRSRVALAgc-dGTILSQIEGGfanltsDFETSRINIETAIRDAYEAAqvpv---dslqRDVAVLGIAGan 88  SAR116 cluster ...
WP_045962745   8 FVIAVDGGGTKCIVRLSdq-sGRVLSQVQTGsanvatNFEVARQNIMEGISQAYAEAgral---nqskGDIIGLALAGae 83  Vibrio nigripul...
WP_133754675   1 MFCGIDLGRSGCRLAVVddrpLVVSSEGGASlid-avDSEGAHSEVVTAALQAILTArdqlpaerrhpAGSLVCGVAGag 79  Naumannella hal...

Feature 1                                                                                        
1ZC6_A        88 -nRQWAGEFESQApg---fARLSLATDGYTTLLGAHgg-qPGIIVALGTGSIGEALYpdGSHREAGGWGYPsGDEASGAW 162 Chromobacterium...
TAN12650      87 -vSRSGERLKAMLp----fSDCVVVTDSVIAMEGALgp-aDGVVAILGTGSVFVARSa-GEVRSIGGWGFVlSDLGSGAR 159 Rhizobiaceae ba...
KPB01596      83 -yEALNTKLKQRLp----fENIIVETDARISLEGAVgs-gDGAAAIIGTGSIYQYRYn-GVEKTTGGWGFMvGDLSGGAW 155 Ahrensia marina
PCJ03353      84 -lPGLTMQLEQALp----fKNIIVTTDQHITIQGAMgd-qDGAIASLGTGSFFVKRQh-GKIRHVGGWGMQlGDECSGAY 156 OCS116 cluster ...
RPG55191      79 -lGNYAKELTQELp----fAKNLILNDGEITLEGAIgp-fDGCIGALGTGSIFVGRKe-GKVSLTGGWGFNlGDDGSGAK 151 Flavobacteriale...
PCJ89467      84 -iGDAGERLTKQLd----fAHCQIVPDTLIAHRGAFag-aDGLLAIVGTGSAFLKIIg-DEHHYFGGWGARvSDLASGAW 156 Hyphomicrobiale...
WP_133572992  83 -aSAQRQELIDRFg----fRRMILATDIDVTLAAALgteqDGLVAMLGTGSFFVWREq-GQVRRVGGWGFIlGDECGGAW 156 Maritalea mobilis
RZO33024      89 -fGDFAARLSGAFd----fAKTYVVSDREIAIAGVLgq-aNGTLAQMGTGSFFVSQCq-GRTKQIGGWGLQlADECSGAW 161 SAR116 cluster ...
WP_045962745  84 -sSDRVGELRESLn----fAQVVICSDLEATLKGALgd-eDGVVASIGTGSFFLSQQn-GAYQRVGGWGLFlSDDCSGAA 156 Vibrio nigripul...
WP_133754675  80 aePELAAELATRLqaelpgTTVQVTSDLVITHAGALgg-rSGSVANVGTGAEVIALSpgGELRQLGNWGPWlGDDGSGAW 158 Naumannella hal...

Feature 1                                                                     #  # #  ##  #   #  
1ZC6_A       163 LGQRAAQLTQXALDgrhshSPLTRAVLDFVGgdwQAXXAWNGRAt--pAQFARLAPLVLSAAr-VDPEADALLRQAGEDA 239 Chromobacterium...
TAN12650     160 LGRALLQEVLLAYDrvhrpSALTDEVLTRFGnepGELVAFARTAa--pRDFGTFAPLLFSFAdrGDPVATRVLDEAVKSI 237 Rhizobiaceae ba...
KPB01596     156 LGRELLQETLLVYDgihagSPLTQAVLDQFGnnpQKIVEFAQGAs--pASFGTFAPMVFDFAdkGDSFGVRLVHKAVANI 233 Ahrensia marina
PCJ03353     157 LGRGLLRRSLHAYDglvehSGLSQNIMQHFGgspQKMIIFARTAs--pQDYASFAPQLIEAFeqGDTNAKEIVNVAVKTL 234 OCS116 cluster ...
RPG55191     152 LGKELMRMSIKCHDglekhTKLTEKLLSEFQndiSKLVEKAKGFg--pKDFAYYAPQIFSALtaGDQIAKKIVFEEVLNI 229 Flavobacteriale...
PCJ89467     157 LGRAVIESTLLAADgirpfTDLAHKALSRFGgdaGALAISCAHAe--pSDFAEYAPMVVDAAaqKDVAALKIMNQAAADL 234 Hyphomicrobiale...
WP_133572992 157 LGRELLRDTIKAYDgvgpsSNLTQKVLDHFGgtpKNMVPFARDSk--aADFAKFAPWITEAVaaGDVVAQQIVNRAVQQL 234 Maritalea mobilis
RZO33024     162 LGRELLRHVMKANDgligeTDLTRDMMQRFGsqpGNIVLFAKTAt--pQDFGQLAPEIFAAQmtGDTVANGIIGTAIADL 239 SAR116 cluster ...
WP_045962745 157 LGKALMRYVANVYDgmlpsSPLVDETFAKFDsqiRKLVNFSLQAs--pKDCAEFASDIVSAYqkGDPVARQLVCSSVSRL 234 Vibrio nigripul...
WP_133754675 159 LGREALRRVLASREadydlGPLVGAATERYGd-lDRLHQTLATSgtpaRSTAAFAGDVLRLAedGEPGALEVTRSAADAL 237 Naumannella hal...

Feature 1        #   #                             ## ### #                 
1ZC6_A       240 WAIARALdpqdelPVALCGGLGqa--------lrDWLPPGFRQRLVAPQgDSAQGALLL 290 Chromobacterium violaceum ATCC 12472
TAN12650     238 GEALDTVkpkhceRICLLGGLApl--------yaKRLESRFQHLLKPPLaDALQGALAL 288 Rhizobiaceae bacterium
KPB01596     234 EETLDRIlpdatsPFCMIGGLGai--------yaQRLGDDYKKHLIAAKgDALSGAVSL 284 Ahrensia marina
PCJ03353     235 DSTLDALdvkaagVLYMLGGLGaf--------yqNLLHPDYQKICQPPKaNAMAGAIML 285 OCS116 cluster bacterium
RPG55191     230 EKSLLAAgfspskPFCLIGGLGkl--------flPHLAEVFRKAVREPKgDALTGAISI 280 Flavobacteriales bacterium TMED235
PCJ89467     235 NEALHALnrenpvSICLWGGLAqv--------yaPLLSRENAARLQSPQtTALNGALSI 285 Hyphomicrobiales bacterium
WP_133572992 235 CDTIGPAhnvpqqHLCFLGGLGrf--------yqSQMPAEYQAICHSAKgEALDGAFWL 285 Maritalea mobilis
RZO33024     240 RRILIALdaaetgRIFLCGSVGerlkellvddvaDEFDHDLAALISSPDgDGLIGAIAL 298 SAR116 cluster bacterium
WP_045962745 235 VEILEFLnaqktgNLCMNGGLAaf--------yrPLMPESYQAIFAEPKgNVLDGITSI 285 Vibrio nigripulchritudo
WP_133754675 238 ASVLQRSgp---gPYAITGGLSghq------vylDEIAGALGQPVTNAEgTALDGALLL 287 Naumannella halotolerans

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