Conserved Protein Domain Family
AdeS_HK

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NF012226: AdeS_HK 
two-component sensor histidine kinase AdeS
Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Statistics
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PSSM-Id: 411090
Aligned: 21 rows
Threshold Bit Score: 583.495
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_004937161   7 KNSIGISAQLLIMMSVLNLGITIFSFGLGYLVYGWATEKGLLDLKNACPDNFSFTSVDYLWTFLVVLTGFLLSTFLAFRY 86  Acinetobacter soli
WP_017392733   2 KYKLGISKQLFIALSIVNLSVTLFSILMGYLVYNYALEKGWITLSSIQEDWTSFHLVDWIWLCTVIFCGSMISLVIGMHL 81  Acinetobacter c...
WP_005089995   2 KNKSGISKQLFIALSIVNLSVTLFSVFIGYVIYNYAIETGWITLGSLEEDWTEFHVVDWVWLFTVIFCGTVISLIIGLLL 81  Acinetobacter
WP_018678943   2 INKVGMSKQLIIALSIVNFSVTAGSVFFGYFIYTYAIETGWISLKTLNEDWSVFHSVDWVWLFFVLLFGSVLSIILGVKL 81  Acinetobacter t...
WP_005197979   2 KNKLGINKQFFIAFSMVNLSITLLSVFVGYIVYNYAIDHGWISLSSLQGDFTDFHLVDWIWLGIVILCGSIISLIIGMQL 81  Acinetobacter s...
WP_000791566   2 KNKLGINKQFFIAFSMVNLSITLLSVFIGYVVYNYAIDHGWISLSSLQGDFTDFHLVDWIWLGTVILCGSIISLIIGMQL 81  Acinetobacter b...
WP_016145432   2 NNKFGINKQLFIAFSMVNLSITFLAIFVGYCVYKYAIGNGWISLSSLQGDFIDFHIVDWIWLFVVGLSGSIISLIIGMQL 81  Acinetobacter l...
WP_005069225   2 KNKTGISKQLIIALSFTSLSVTLSSLILGYGTYYVAIEVGLISLEKLKESDEFFHYLDGIWLFAVLLFGTALSIILGIKL 81  Acinetobacter
WP_019459149   2 KNKTGISKQLIIALSFTSLIVTLSSLILGYGTYYVAIEVGLISLKKLKESDEFFHYLDGIWLFAVLLFGTAFSIILGIKL 81  Acinetobacter
WP_010326702   7 KNSVGINFQFIIMMSLLNLGVTLLSFMIGYFVYSWAIEIGFLDFQSVNSNEFFITSVDFIWLFLVLLTGFFLSTLLAFKY 86  Acinetobacter
WP_004937161  87 AKRYTQPINALANVVKQIQQGNLSLRIEqQQAHIPHELMSLIQNFNAMANQLEISVKNSTLWNAAIAHELRTPITILQGR 166 Acinetobacter soli
WP_017392733  82 AKRFIIPINFLAEAAKKISQGDLSARAY-DNRVHSAEMSELLYNFNNMAQKLEVSVKNAQVWNAAIAHELRTPITILQGR 160 Acinetobacter c...
WP_005089995  82 AKRFIVPINSLANAAKEISLGDLSARAE-DTKIHSTEISELMHNFNNMAQKLEDSVKTAQVWNAAIAHELRTPITILQGR 160 Acinetobacter
WP_018678943  82 ANRFIIPINFLADAAKKISQGDLSARVE-DAEGHSAEILELMHNFNSMAQQLETSVKNAQVWNAAIAHELRTPITILQGR 160 Acinetobacter t...
WP_005197979  82 AKRFIVPINSLADAANKISEGDLSARAN-DQKIHSSEISKLIINFNDMAQKLESSVQNAQVWNAAIAHELRTPITVLQGR 160 Acinetobacter s...
WP_000791566  82 AKRFIVPINSLADAANKISEGDLSARAN-DQKVHSTEIYTLILNFNDMAQKLESSVQNAQVWNAAIAHELRTPITILQGR 160 Acinetobacter b...
WP_016145432  82 AKRFIVPINSLSNAANKISEGDLSARAN-DQQIHSSEISRLILNFNGMAQKLEDSVHNAQVWNAAIAHELRTPITILQGR 160 Acinetobacter l...
WP_005069225  82 AQRFIVPINLLADAAKKISHGDLSARVE-KPTHHSSEIGELMDNFNDMAQKLETSVENAHVWNAAIAHELRTPVTILQGR 160 Acinetobacter
WP_019459149  82 AQRFIVPINLLADAAKKISQGDLTARVE-SSMHHTSEIAELMHNFNDMAQKLETSVQNAHVWNAAIAHELRTPVTILQGR 160 Acinetobacter
WP_010326702  87 GKRYTQPISDLADVIQQIQQGNLALRIKqPHHDIPHEIKSLIENFNAMANQLEVSVKNSTVWNAAIAHELRTPVTILQGR 166 Acinetobacter
WP_004937161 167 LQGIVDGVFEADQQLHQSLLSQVEGLSYLVEDLRTLTLVENQQFRLDIQETNLQNSIFKCFQMFQDRFEHKGLHVVFNLT 246 Acinetobacter soli
WP_017392733 161 LQGIIDGVFKPDEVLFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYELFDFKSVLEKVLKAFEDRLQQANLVPELDLT 240 Acinetobacter c...
WP_005089995 161 LQGIVDGVFEPKPKLMKSLLNQVEGLSYLVEDLRTLSLVENQQLRLNIEAVNFQACVDKVISMFGERLKQAHLTIETEVS 240 Acinetobacter
WP_018678943 161 LQGILDGVFQPDPVLFKSLLNQAEGLSHLVEDLRTLSLIENQQLRLNFEWIDLEYHVERVLLIFKERLHQTGFNIQVELS 240 Acinetobacter t...
WP_005197979 161 LQGIVDGVFEPEPNLIKSLLNQVEGLSHLVEDLRTISLFENNQLKLNIEPLDFLRCVEKVVLMFDEKLKEAKLRIDYDIS 240 Acinetobacter s...
WP_000791566 161 LQGIVDGVFNAEPELIRSLLNQVEGLSHLVEDLRTLSLFENKQLKLNIESVDFLRCVEKVIRMFDEKLKQANLTVNYDIS 240 Acinetobacter b...
WP_016145432 161 LQGIVDGVFIAEPNLMRSLLNQVEGLSYLVEDLRTISLFENNQLKLNIESIDFLKCVEKIVQMFEEKLIQAKITIVSDIS 240 Acinetobacter l...
WP_005069225 161 LQGIIDGVFEADPILFKNLLNQVEGLSNLVEDLRTLSLFENQQLRLNLETICFNETAHKVLHMFEEKLEKAQLKVIFDIE 240 Acinetobacter
WP_019459149 161 LQGIIDGVFKPDPVLFKNLLSQVEGLSNLVEDLRTLSLFENQQLRLNIETINFNETAYKVVHMFQEKLQTAQLKVAFNIQ 240 Acinetobacter
WP_010326702 167 LQGIVDGVFIADQALHQSLLNQVEGLSYLVEDLRTLTLIENKQLRLELEKTNLKDSIEKCLQMFHERFQFKGLTTVLNLT 246 Acinetobacter
WP_004937161 247 HETARCDVTRMEQVLIALFSNASRYADAGKLSITTKTTQDHWILMLEDQGPGIDEQHLEHLFKPFYRLEESRSRSEGGTG 326 Acinetobacter soli
WP_017392733 241 TTPVFSDRRRIEQVLIALIDNAIRYSNAGKLKISSVVDSQNWTLKIEDEGPGIATEFRDDLFKPFFRLEESRNKEFGGTG 320 Acinetobacter c...
WP_005089995 241 KDIVHCDRQRMEQVLIALVDNAVRYANAGLLTIRSRIDANDWILQIEDEGPGIALEYQHDLFDPFFRLEESRNKEFGGTG 320 Acinetobacter
WP_018678943 241 VTQVYCDSRRIEQVLIALIDNAIRYVNAGVLKISSNMIEQSWVLQVEDEGPGIPIEYQRDLFNPFFRLEQSRNKELGGTG 320 Acinetobacter t...
WP_005197979 241 NDIVFCDKRRMEQVLIALVDNAIRYSNPGVLRIRSSVQQDKWTLEIVDEGPGIPVEYQKELFDPFYRVEQSRNKALGGTG 320 Acinetobacter s...
WP_000791566 241 NDLVTCDARRMEQVLIALIDNAIRYSNPGVLKIKSSVQQEKWTLEIVDEGPGIPVEYQKELFNPFYRVEQSRNKALGGTG 320 Acinetobacter b...
WP_016145432 241 HDSVWCDSRRIEQVLIALIDNAVRYSNSGVLKIKSSVERDQWTLEILDEGPGIPLEYQKELFNPFYRVEQSRNKALGGTG 320 Acinetobacter l...
WP_005069225 241 APKVECDQRRIEQILIALLDNATRYANQGKLIVSTRQEQTSWILEIEDEGPGISAEHRKDLFNPFFRLEQSRNKELGGTG 320 Acinetobacter
WP_019459149 241 APEVKCDHRRIEQVLIALLDNATRYANPGNLKISTQYHQHDWVLEIEDEGPGISAEHHKELFNPFFRLEQSRNKELGGTG 320 Acinetobacter
WP_010326702 247 DELVCVDVRRMEQVFIALFSNFLRYSNAGQINITTVTTTEHWVLTFEDEGPGINESHLEHLFKPFYRLEDSRSRLDGGTG 326 Acinetobacter
WP_004937161 327 LGLAVIYAIIEAHQGQITYTTSTdlGGSCFTILLKK 362 Acinetobacter soli
WP_017392733 321 LGLAVIHAIIVAMKGTIQYSNQG--SKSVFTIKISM 354 Acinetobacter calcoaceticus/baumannii complex
WP_005089995 321 LGLAVVHAIVVAHQGSIQYENKK--PNSVFTIRIPM 354 Acinetobacter
WP_018678943 321 LGLAVVHAIVVAHKGLIKYSNFQ--NNSVFVIILPL 354 Acinetobacter tjernbergiae
WP_005197979 321 LGLAVVHAIVLAHSGSIRYENVN--ANSAFIIELKN 354 Acinetobacter sp. NIPH 298
WP_000791566 321 LGLAVVQAIVLAHAGTIRYENRI--PNSAFIIQLKT 354 Acinetobacter baumannii
WP_016145432 321 LGLAVVQAIVLAHSGTIRYQNRN--NRSVFTITLPM 354 Acinetobacter lactucae
WP_005069225 321 LGLSVVQALVIAHKGQVDYLNQH--SHSIFRISIPQ 354 Acinetobacter
WP_019459149 321 LGLSVVQALVIAHKGRVDYINEN--SHSIFKISIPQ 354 Acinetobacter
WP_010326702 327 LGLAVIDAIIEAHQGHIYYSKSKslGGSCFTIQLKA 362 Acinetobacter
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