SWIB domain found in BRG1-associated factor 60A (BAF60A) and similar proteins
BAF60A, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1), or 60 kDa BRG-1/Brm-associated factor subunit A, or SWI/SNF complex 60 kDa subunit, is a core subunit of the SWI/SNF chromatin-remodeling complex that activates the transcription of fatty acid oxidation genes during fasting. BAF60A is involved in chromatin remodeling and hepatic lipid metabolism. It mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. It is also a key component of the transcriptional control in cardiac progenitors. Moreover, BAF60A interacts with p53 to recruit the SWI/SNF complex, suggesting that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors.
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
Comment:The SWIB domain and the MDM2 domain share a common evolutionary origin and thus adopt similar structures, which suggests the SWIB domain may interact with a helical peptide through a cleft on the surface.
Comment:Based on the structural evidence that MDM2 domain binds p53 or other peptides.
Jiyao W et al.(2023). "The conserved domain database in 2023.",