1SEN


Conserved Protein Domain Family
ERp19
?
cd02959: ERp19 
Click on image for an interactive view with Cn3D
Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that the protein is involved in disulfide bond formation. In vitro, ERp19 has been shown to possess thiol-disulfide oxidase activity which is dependent on the presence of both active site cysteines. Although described as protein disulfide isomerase (PDI)-like, the protein does not complement for PDI activity. ERp19 shows a wide tissue distribution but is most abundant in liver, testis, heart and kidney.
Links
?
Statistics
?
PSSM-Id: 239257
Aligned: 6 rows
Threshold Bit Score: 175.009
Created: 15-Nov-2004
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
catalytic
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:CXXC motif
  • Comment:In vitro, ERp19 possesses oxidase activity which is dependent on the presence of the active site cysteines.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                   #  #                                              
1SEN_A     28 DHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISE---LSHNFVMVNLEDEEEPKDEDFSPDGGYI 104 human
NP_496599  35 DDIAWVKWEDAIETALDTDKPIFLLIHKSWCHACKALKKTFQQSNAKKAfkkLSEHFVMVNTEDDDEPFEEEYRPDGKYI 114 nematode
NP_508381  32 SAIEWVEFDKAIGIAKDLNKPIFFLIHKTWCGACKSLKRELKSSPKTDEliiLSRKFVMVNVEDDEEPEDPKYSPDGGYI 111 nematode
AAH44076   34 DHIHWRTLEDGKKEATSSGLPLMLVIHKTWCGACKALKPKFAESKEISE---LSHNFVMVNLEDEEEPKDESLSPDGGYI 110 African clawed frog
AAH95367   36 DHIHWRSLEDGKKEAEASGLPLMVIVHKTWCGACKALKPKFAESKDISE---LAHNFVMINLEDEEEPKDEAFSPDGGYI 112 zebrafish
XP_791682  42 EQYDWATFEDGLKLDKENNKPLMLVIHKTWCGACKALKPKFAASEEILK---LSSDFVMVNVEDDEEPEGSQFQPDGGYI 118 Strongylocentrotus...

Feature 1                                              
1SEN_A    105 PRILFLDpsgKVHPEIINENG-NPSYKYFYVSAEQVVQGMK 144 human
NP_496599 115 PRLLFLDkngDLLQEFKNKKAeYKNYAYYYSSPADILNSMK 155 nematode
NP_508381 112 PRILFLDt--DGNPLKTNNERkYKNNKYFYPLPAQIIDGME 150 nematode
AAH44076  111 PRILFLDpsgKVHPEIINSKG-NPSYKYFYNTAEQVTEAMK 150 African clawed frog
AAH95367  113 PRILFLDptgKVHSEITNKNG-NPNYKYFYSNADQVVASMK 152 zebrafish
XP_791682 119 PRILFLNsdgVVQPDLINTLG-NPQYKFFYSNALMVTEAMK 158 Strongylocentrotus purpuratus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap