Conserved Protein Domain Family
NKAP

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pfam15692: NKAP 
NF-kappa-B-activating protein
NKAP is a family of eukaryotic proteins that interacts with NF-kappa-B. It is a nuclear regulator of TNF- and IL-1-induced NF-kappa-B activation. NKAP does not interact with RIP in mammalian cells family is often found in association with pfam06047.
Statistics
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PSSM-Id: 464805
Aligned: 37 rows
Threshold Bit Score: 40.1299
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESO11140             48 NDSSSSRSayn--nvWLREFDRLESSMADKWGHTGYKEMHPEDFQPSPSPSPDQNDY--------NDTRRHSGRRNNTEC 117
EFX79336             71 RVMERARTegg--nrWTKKLLDEEAKDPDRWGHSGFKEMYKNELGISR-------------------SRRSRSREKTS-- 127
EEZ98772             48 TVMKKARAspnsnayWDKKLLEVEAKDPNRWRHSGYKSLYIDGSSSPSSGHRSRSRSp-------TGRRSPPRRSPVRRS 120
EGI64175             23 SVMRKAREshs--syWNKKLLEAEERDPNRWRHSGYKELYVG---SSSEPSRGHPKSp------rSPRSRSPHSPRPR-- 89 
XP_016772924         45 SVMRKAREsqs--syWNKKLLEVEERDPNRWRHSGYKELYVGGT-TSGEPSRGHPRSp------rSPRPRSPHIQRPR-- 113
XP_011269470         45 NVMRKAREsqs--syWNKKLLEAEERDPNRWRHSGYKELYVGGTGGSGEPSRGHPRSp------rSPRPRSPHSPRPR-- 114
XP_011154451         46 NVMRKAREsqs--syWNKKLLEAEERDPNRWRHSGYKELYVGGTGSGEPSSRGHPRSp------rSPRPRSPHSPRPR-- 115
ETN58786             56 NVMKKARAfpn--etWDKKLLEAEEKDPNRWRHSGYKKLYLEDDPSSSDSERPVrf--------gNG------------- 112
4_pfamImport          1 NVMKKARAgtn--dyWDKKLLEVEEKDPNRWRHTGFKKMYIEGDESGSSGGESDRES------------RYKRSNNGR-- 64 
WGS:AAPU:GI20931-PA  39 NVMKKARAntt-ndyWDKKLIEAEEKDPNRWRHTGYKKMYIQGESSSGESERDSAQAsysrysgaPGNAGPPPSSASS-- 115
ESO11140            118 csrdngdiEDRKKKKKTDKKKKRK 141
EFX79336            128 --------ARRSRSRERAHKIESG 143
EEZ98772            121 --------PVSRRSPRSPIARRSP 136
EGI64175             90 --------SPRTRSPRSPRERSSR 105
XP_016772924        114 --------SPRTRSPRSPRDKSHT 129
XP_011269470        115 --------SPRARSPRSPRERSSR 130
XP_011154451        116 --------SPRARS-RSPRERSTR 130
ETN58786            113 --------GRRSRSPRSP-PRNRR 127
4_pfamImport         65 --------EREEVYRRQSRSRSRS 80 
WGS:AAPU:GI20931-PA 116 --------SARYGRSRSPHSRSRS 131
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