4E4W


Conserved Protein Domain Family
Mlh1_C

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pfam16413: Mlh1_C (this model, PSSM-Id:406741 is obsolete and has been replaced by 465109)
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DNA mismatch repair protein Mlh1 C-terminus
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Statistics
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PSSM-Id: 406741
Aligned: 172 rows
Threshold Bit Score: 130.724
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4E4W_A         26 NLTSIKKLREKVDDSIH-RELTDIFANLNYVGVVDEerRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDF-----ANFGK 99   Saccharomyces...
Q57TS9        623 LLTSVSTIVSNIRAGTS-QTAQSLFQNLAYVGVLKG--HLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWatpslSAVPQ 699  Trypanosoma b...
XP_001016280  505 RIQVQQQLLSLRNQDIH-DTTSSFFKNLTYVGCISSnhFLA--QFRDDLYLINSIPLCQEIFKFEILRNF-----GQIKP 576  Tetrahymena t...
Q8IIJ0        710 EISSIKKLKMICEEKEK-KELTECLKNSIYVGPVDN--MHSLIQYKEKLLLIKMPLIIKEVTYQSILNRL-----GKIPP 781  Plasmodium fa...
CAQ39952      560 dISSIRKLKRICEEKEK-KELTECLKNSIYVGAVDN--LHSLIQYKDKLLMIKMPLIIKEITYQSILNRI-----GRIPP 631  Plasmodium kn...
Q5CRJ3        548 TEIEIMNDNTEASKMEYlKSLTKNIINGIYIGQIKS--SWSIIQAKNQILLINIEQMSKIALKQSLICRL-----GYIPL 620  Cryptosporidi...
1_pfamImport    1 EFESLEFLRRQIVNESS-LSLRNLFKTCIFVGSIDP--QTILVQFGTSLYQIDFAAVLREFFYQISIFSF-----GNYGS 72  
Q9XU10        501 HFESIEVLRKEIIANSS-QSLREMFKTSTFVGSINV--KQVLIQFGTSLYHLDFSTVLREFFYQISVFSF-----GNYGS 572  Caenorhabditi...
EGT60154      500 DFESLDIIRRQIVSTTS-LSLREMIKTSTFVGSIDC--EQVLFQFGTSLYIMNFKAVLREFFYQISIFSF-----GNFGS 571  Caenorhabditi...
CAP33641      500 EFESLEILRHQIASSAS-LSLRELIKTSTFVGSIDP--ETVLIQFGTSLYMLKFSEILREFFYQISILSF-----GNYGS 571  Caenorhabditi...
4E4W_A        100 INLqstnvsDD-IVLYNLLse---fdELNDDA-----------------SKEK----IISKIWDMSSMLNEY---YSIEL 151  Saccharomyces...
Q57TS9        700 LSF------EEpIHLSDLLs------FALQNDvqlppsqk-radggpgsLLSR----LGRRLCNWRYMLQDY---FAVEI 759  Trypanosoma b...
XP_001016280  577 VEL------NQaIGLKDILeyfllnfdEIPNEkkef----------hlsNMDT----YIEQFGLLSDFLRDS---VGIVI 633  Tetrahymena t...
Q8IIJ0        782 FEF------DPpIPLYDLLl------VAVNNSysgfyenpnyankniekVCNE----LEQIFYTYNEMYSDY---FSIII 842  Plasmodium fa...
CAQ39952      632 FKF------DPpIPLYDLLl------VAMNNSqsgyfenpdyvtknierICNE----LEQVFYSYEEMYADY---FSIII 692  Plasmodium kn...
Q5CRJ3        621 LKL------NPpVSLGELS--------LFGTEsvk-----------nykLNENdqiqLKDFINSQAYLYFDIlkvLGIDF 675  Cryptosporidi...
1_pfamImport   73 YRLe-----EDpPAIQELLell--geLSASDEnyaafevf---------agaekrkeAEAMLAEHAELLNDY---FAIKL 133 
Q9XU10        573 YRLd-----EEpPAIIEILell--geLSTREPnyaafevf---------anvenrfaAEKLLAEHADLLHDY---FAIKL 633  Caenorhabditi...
EGT60154      572 YRLe-----QEpPSILEMLeli--geLSENDErykgfgvf---------kqeekrveAENLLGEQAELLHDY---FAIKM 632  Caenorhabditi...
CAP33641      572 YRLe-----EEtPLIIDMLeli--geLSETDEnykafsif---------rdpttreeAEFLLGEHVELLYDY---FAIKM 632  Caenorhabditi...
4E4W_A        152 vnd--glD-NDlksVKLKSLPLLLKG-Y--IPSLVKLPFFIYRLGKEVDWE--DEQECLDGILREIA-LLYIpdmvpk-- 220  Saccharomyces...
Q57TS9        760 -------S-AD---GHLIALPLSMGTsW--PPPLRAVPLFIWRLAAEVPYNa-GEIECFTAIARHIAeTLYGvql----- 820  Trypanosoma b...
XP_001016280  634 ---------KD---QKLLAFPNLFNL-FenDNNFKDISYILLRIITKVNFS--EILQSGMGLANELS-FYFAwql----- 692  Tetrahymena t...
Q8IIJ0        843 ---------ED---GCIVTFPACCGE-Y--FPGQEFLPFLFLRLATQIDYS--KEINCINGICYLLA-NFYSkitllndk 904  Plasmodium fa...
CAQ39952      693 ---------ED---GCVCTFPACCGE-Y--FPGQEFLPLLFLRLATQVDYE--NELNCINGICYLIA-NFYSkvtllddk 754  Plasmodium kn...
Q5CRJ3        676 -------DsSN---NSFSTLPLFFGN-F--VPNIDFLPELFEHVIFA-CWNfhIAHACKQKLLNTGSaQILNphfn---- 737  Cryptosporidi...
1_pfamImport  134 ewsdenlGeKK---LILTGIPSLVHY-Y--VPQLEKLPFLIAELVLEVDYD--DEKSCFESICRALG-RLFSlh------ 198 
Q9XU10        634 dq----lEnGR---LHITEIPSLVHY-F--VPQLEKLPFLIATLVLNVDYD--DEQNTFRTICRAIG-DLFTld------ 694  Caenorhabditi...
EGT60154      633 ewfgeeeDqRR---LHLTEIPSLVHY-Y--VPQLEKLPFLIAALILDVDYD--DEQKCFESVSRAIG-DLFTlh------ 697  Caenorhabditi...
CAP33641      633 ewmclegEkRR---LHITEIPSLVHH-Y--VPQLEKLPFLVASLILDVEYD--DEQKCFQSICRAIA-ELFTlh------ 697  Caenorhabditi...
4E4W_A        221 -------------------------------------------vdtsdASLsEDEKAQFINRKEHISSLLE--------- 248  Saccharomyces...
Q57TS9        821 ---------------------------------------------hssWLPnVIKDGIRQDDVPPFCDAIR--------- 846  Trypanosoma b...
XP_001016280  693 ---------------------------------------------eksFKNqLQRQHFQETQKQKWDDFFE--------- 718  Tetrahymena t...
Q8IIJ0        905 ewtyqddllmiqekekeiqmllnksnkhinnsnhhnqhydetnldyilGDEsVVDINKHLSVSRNINLVFE--------- 975  Plasmodium fa...
CAQ39952      755 ewtfqnellmlkekeiqmlq-gqattdgsgeasplanddqtyhfenilGDEtVIDVNRHLAASKNINLVFE--------- 824  Plasmodium kn...
Q5CRJ3        738 --------------------------------------------eennCLSdKISEDYIIKLYELFIELIEilvdyylfg 773  Cryptosporidi...
1_pfamImport  199 ----------------------------------------------tgFVTaDKLVSKFST--MRWKPMVK--------- 221 
Q9XU10        695 ----------------------------------------------tnFITlDKKISAFSA--TPWKTLIK--------- 717  Caenorhabditi...
EGT60154      698 ----------------------------------------------khFVTdEKKVSRFST--MYWKPLIK--------- 720  Caenorhabditi...
CAP33641      698 ----------------------------------------------spFITaEKKVSAFCG--THWKPLIK--------- 720  Caenorhabditi...
4E4W_A        249 ----HVLFPCI---KRRFLAPRHILK--DVVEIANLPDLYKVFERC 285  Saccharomyces cerevisiae S288C
Q57TS9        847 ----FGLLPCAt-nSTFFVPPCDALVdgTVQAVVSVDELYKVFERC 887  Trypanosoma brucei
XP_001016280  719 ----QKMLPMI---KKKLSLPKLDISe-FTVKLFKQEDAYKIFERC 756  Tetrahymena thermophila SB210
Q8IIJ0        976 ----KYFFPMIq-lNNIMKIPTTFSNngYIIELTSLNQLYKIFERC 1016 Plasmodium falciparum 3D7
CAQ39952      825 ----KYFFPMIq-lNTIMRVPRTFSTngYIIELTSLNQLYKIFERC 865  Plasmodium knowlesi strain H
Q5CRJ3        774 iednELLFQAIrnnNNLILVEDQISQn--IIELSSLEKLYRVFERC 817  Cryptosporidium parvum
1_pfamImport  222 ----HILFPLV---KRKLIPPESFKQqnVIKQLADAHDLYKVFERC 260 
Q9XU10        718 ----EVLMPLV---KRKFIPPEHFKQagVIRQLADSHDLYKVFERC 756  Caenorhabditis elegans
EGT60154      721 ----QILMPLV---KRKFIPPEHFKEkqIIKQLADSHDLYKVFERC 759  Caenorhabditis brenneri
CAP33641      721 ----QVLMPLV---KRKFIPPEHFKSadIFVQLADSHDLYKVFERC 759  Caenorhabditis briggsae
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