Conserved Protein Domain Family
TM6SF1-like
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cd21106: TM6SF1-like 
transmembrane 6 superfamily member 1, member 2, and similar proteins
This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).
Links
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Statistics
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PSSM-Id: 411047
Aligned: 58 rows
Threshold Bit Score: 314.89
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_075379      6 ATGVFVLSLSAIPVTYVFNHLAaq----hDSWTIVGVAALILFLVALLARVLvkrk--------pprDPLFYVYAVFGFT 73  Homo sapiens
XP_001742584 172 TAGCAMASFLAIPFLYAVDAHPev---isDPVYMAVVGCVTLTAFPILVYYSifrhm-----prfqfDVFMLFFALFAFT 243 Monosiga brevic...
XP_002129070   7 VLASCFISLSGIPLVVFVTNSDvl----sQPINLMAIGFTSMATIVVFVYLVvppngikkeegkegrGVLYYTCCLFMWA 82  vase tunicate
XP_004994066  76 AGKVAALTLLAVPVCYLFDFFGen----lSGFGTFLFGLTILIGFPMGLRDMfsvi--------pdhDMFMYFFSVFAFT 143 Salpingoeca ros...
OWF51375       6 VVVICLTSLIGLPLTYSVNLFKdn---vsNPLIILGIGGVALILVALLPYLYtrntd------ipkrDPYFYAWSLFAFA 76  Yesso scallop
XP_021936721  15 TIVALVVGLLSLPICFGYTLLCel----lPPVGMLGLAGAILAGVLAIFVILtkg---------kvkNKMYYGFAVFIFT 81  Zootermopsis ne...
XP_021951900  16 VGLACLISQLAWPFMYIFNTLFlhlnpkfMDLYMFIAGYFLLGLIVVITRKLfp-----------gkDWVLYSSTVFAFT 84  Folsomia candida
XP_021962451  13 LWLSFWMSFLAWPVVYVFNNGFgkvdaahRPFVMMTAGFGMMAAIGWLCAKLsk-----------ttSRIGVVFMLFIFT 81  Folsomia candida
XP_022335240   6 TLVVLFASILSVPIAYFVNLIPgi---seKPVAIFIIGLSCLLVAFLIPALAkvykl------vkndDPLYYAMSILTFA 76  eastern oyster
XP_004227050   7 VTIALLVGQSAWLVLYLASVFPi-----lSTAPCLLGYASYISLLFLFTKILppkkkne-npekckrGGLYYVCCLFTWC 80  vase tunicate

NP_075379     74 SVVNLiiglEQDGIIDGf-mTHYLREGEPYLNTAYGhmICYWDGSAHYLMYLVMVAAIAWEETYRt--iGLYWVGSIIMS 150 Homo sapiens
XP_001742584 244 SMVDLmlalTIDGRSTVm--KWYLDAGESYLNSSYGfaANIFDATAHWLLYMVMIYGLSSHNPASwryvYLYWCGSVMFS 321 Monosiga brevic...
XP_002129070  83 SMTDLalqgQRFGLFGLksgTGYFEHGEPYLDTPFGlgVQGWNAIVNYLLYIHIIYNIDNNKDPRy--tAIYWAGGILTS 160 vase tunicate
XP_004994066 144 SAIDFilafTIDKRNAVl--VDYLERGEPYLSTAYGfaANLWDGTAHWLLYIIMIFGLASHNPALyrsyYLYWIGSITFS 221 Salpingoeca ros...
OWF51375      77 CVVDLiialENDRIIHSf-mAFYLLEGEPYLKTTHGtfINYWDAVVHFSLYIYILKQDSYNERYRk--aGLYWVGSITNS 153 Yesso scallop
XP_021936721  82 GIIDIlsglEMDGIVHGf-lTLYLKHGEPYLVSAWGavVAYWDGTVFLTCYIIMAYLSSNGRSYRt--iGLHWSSAILNS 158 Zootermopsis ne...
XP_021951900  85 CVVDLiislEVNGNVSGf-mTQYLKYGEPYLNSSFGfaICLFDGIVYYAMYFIMIFAIANGKKYKc--vGLYWCGAIICS 161 Folsomia candida
XP_021962451  82 CMIDLiialEYYGHITGf-mWRYLELGEPYLNSPWGsaITLFDGIGLYVMYLAIIHRISNRKNWHt--iGIYWVSAIINS 158 Folsomia candida
XP_022335240  77 AVIDFtialENDGIVHSv-mAFYFVSGEPYLKSGHGsgINYHDGIIHFACYIIILLAIDNRKNYRe--vGLYWGGSIINS 153 eastern oyster
XP_004227050  81 TVTDLifylEVIGMVDGf-iGFYLKNGEPYLDSSFGtvALLWDPLGNLIVYLIIIYRIDNNLDCRn--aVLYFSGTLITS 157 vase tunicate

NP_075379    151 VVVFVPGNIVGKYgtrICPAFFLSIPYTCLPVWAGfriynqpsenyny-------------------------------- 198 Homo sapiens
XP_001742584 322 LINLLAGGTISHIshaLQPSSFLNTPYVLFPLIFLkrvfdtpr------------------------------------- 364 Monosiga brevic...
XP_002129070 161 QFCVIVGAYSGSFatyLPPSVAMNIVFVVFPMWVFfhflnkprs------------------------------------ 204 vase tunicate
XP_004994066 222 LCKLMPGAAIGHFshaMDYSAFLNVPFILLPVYFLkrvidtp-------------------------------------- 263 Salpingoeca ros...
OWF51375     154 LLIILPAGLIGEYg--VRWPILLNMPYLCIPVWMGykfltnapqhqtq-------------------------------- 199 Yesso scallop
XP_021936721 159 MVILLLGACLSQSg--PGWCTILNIPYVLFPLAVAvqclaetpk------------------------------------ 200 Zootermopsis ne...
XP_021951900 162 SLLVEIYGFCMGGphgPTMASLLNTPYIVVPIIALfrffaeekkn----------------------------------- 206 Folsomia candida
XP_021962451 159 MIVLLMGVATGKHs--PTFCTFLNVPYVVFPCYVLyyllkkdcqpnwnesaattpgeeeekvekvekpkkgkkvekvekg 236 Folsomia candida
XP_022335240 154 LIVLMIGGAVGMHg--AKWSMLLNVIYMVLPIWITkkvldkpsn------------------------------------ 195 eastern oyster
XP_004227050 158 LFCLLVGGVSGTHgkqLYPSTWLNVPYVVAPIYYLlefvskprqf----------------------------------- 202 vase tunicate

NP_075379    199 ----pskviqeaqakdLLRRPFDLMLVVCLLLAtgFCLFRGLIALDCpsel------crlYTQFQEPYL--KDPAAYPKI 266 Homo sapiens
XP_001742584 365 ---------parradaFCRPSVDFHFAIFFVLAmiAIYVRFAASAGSews-------larAWREIEPTL--TDETGFFRV 426 Monosiga brevic...
XP_002129070 205 --------dkiqainsTKYRALDIFLITGLLVAsfFMIIRGLGALDSpfpl------tkyYVTTHEPYI--MEPGKFGAT 268 vase tunicate
XP_004994066 264 ---------rpiepakRGTAWMEAAFAALLSVAviVLGIRFAAANNSdlp-------iaaAWREVEPTL--DDPSRFFAV 325 Salpingoeca ros...
OWF51375     200 ----yksdsdqrgsqpIQQRPVDLMFIVVFTAAigVHVLRASAVLGSpael------aknYLQQYEPYL--TDGVAFPKV 267 Yesso scallop
XP_021936721 201 --------plhqpqtnGKPSWLDKALVFLLIESslAALLKGLATCGSkqyv------ptwYRTMAEPILqeEEPAPFAAI 266 Zootermopsis ne...
XP_021951900 207 ------psvqwspnfsLSLRPRETKIVTSVLFF--FTVLSMWSIVSLaygslgsdfwlftWISKATPSInfRDPEPFSQI 278 Folsomia candida
XP_021962451 237 eegekgeeayllfgrkWLAKFFEWGIVIGFICTilLTITKAFLSLGStfy-------mfrWYTAHDPSLmnNNPAPFAKI 309 Folsomia candida
XP_022335240 196 -------mkvisadesILKRPVDIISICLLLSTmfIYIYRGLAALGCnsei------tknLVQKYEPYI--TDPLAFPKI 260 eastern oyster
XP_004227050 203 -------sketitkvsTEYKISDILLSLGLFATfvFGIIRGLSAFGSpmyl------anvYSKDFEPYL--MDPSKFGAV 267 vase tunicate

NP_075379    267 QMLAYMFYSVPYFVTALYGLv----vPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPee-----akILFLA 337 Homo sapiens
XP_001742584 427 FGYLGLCYHIPYCLVVVACLllganrVQTEVLTDISVLMAGGFMETYFCFCVSAVYKLTNEASRISdeq----apAFWTI 502 Monosiga brevic...
XP_002129070 269 WVLYGFIYGVPFQLFAIYGLl----hSGCEWMMDLVVFYAAGMLQGTCVYMAYTWFPMSNPEYHIPqas----myMVIAI 340 vase tunicate
XP_004994066 326 TSMVHLYYAVPMMSVLIVTMlfgasrTQRGFCSDVAVLLAGGMGESQFCYMVSAFHHLTPDNLRVSpd-----scGFWGI 400 Salpingoeca ros...
OWF51375     268 QMLLYLFYFVPYYVLVIFDLly---pSGQSWVVDWSLIMAGASGEGQFSFIGASIHPYTPAASQLPqgn----nlLFWVI 340 Yesso scallop
XP_021936721 267 QGLVTLFYFLPGYLVVAWGImv---nPGQRWLQDLAVILAGATLHAGGSTVGIVLHKLTKPEHQLTstvnhsaywAFWGV 343 Zootermopsis ne...
XP_021951900 279 QVLIYLFYVCPMHIIFLANCfk---pQKPQFLWNLLIVQAGIALQGQFTMIGISLYEVTTPAEYLSspg----sfAFWFS 351 Folsomia candida
XP_021962451 310 QSVVLFFYSLPIQVLCLLYAcr---aTRPQYLWDLAVVNAGIFHQAIFTSIVTALDSKAPAGYQADlt-----dpYFWIL 381 Folsomia candida
XP_022335240 261 QMVTYLFYFVPFCAFASYSLfn---aPAKKWFLDWLIIYAGATLNGQIPYIFGSLHHLTPSKYRLPktpe--aqwAFWTQ 335 eastern oyster
XP_004227050 268 WVIYFMIIGSILQISIVFGLf----nPGSSWVLDLSIIYAAITIHGTFIHLIPQFCEGVLPKYHIPpga----qwLVVLG 339 vase tunicate

NP_075379    338 LNIAYGVLPQLLAYRCIYKPEFF 360 Homo sapiens
XP_001742584 503 NVLLVLLTHVFAAHCIYSLPFKG 525 Monosiga brevicollis MX1
XP_002129070 341 NVFLVFISNLLLWRCFAEPQYFV 363 vase tunicate
XP_004994066 401 NVGLVVLTHAIAVYLTSRRGLAG 423 Salpingoeca rosetta
OWF51375     341 NGALFIVPHLYAYRCVTMPTKSE 363 Yesso scallop
XP_021936721 344 NILLSIVPQIVALRLTWLPVQVR 366 Zootermopsis nevadensis
XP_021951900 352 HLLILIVPHAQLYFLYKGHVDKG 374 Folsomia candida
XP_021962451 382 NMTLLTVPHMFLVLLYERHRLQA 404 Folsomia candida
XP_022335240 336 NVFLLIVPQVLLIYYYCANSKGE 358 eastern oyster
XP_004227050 340 NLFIPIVAVSVVIRCFKEQSYFK 362 vase tunicate
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