6325110 13 SLLLNLHTHCIGLHVNDvTpKVYFKLLIRHLLQISRSnAAHPKLRRRAQILLVSLFLsgVTLFSgvtySTFKIILKCYKf 92 baker's yeast 17989321 6 QISQQALQARER----------SAVSRMTSFWGLLRA-YWVSDRWKEAWALTAAIFL--ITAFI----SKTTVWVAEAS- 67 Brucella melitensis 1175812 13 WILTALFWVVLCFS-VTmL-ALKQTTFGKKFWCIVSP-SMDKKTSIKLILMLLVLFI--MILLE----VRFSVLNSFFY- 82 Haemophilus influenzae 15828127 22 WIAKAWAISAACVV-VLvM-LSFITRWGRQYWRITRG-YFIGPQSVGVWLMLAVLLF--SVVIS----VRLNVLFSYQS- 91 Mycobacterium leprae 2492589 22 WVGKAWTISAICVLAILvL-LRYLTPWGRQFWRITRA-YFVGPNSVRVWLMLGVLLL--SVVLA----VRLNVLFSYQG- 92 Mycobacterium tuber... 2492589 22 WVGKAWTISAICVLAILvL-LRYLTPWGRQFWRITRA-YFVGPNSVRVWLMLGVLLL--SVVLA----VRLNVLFSYQG- 92 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 1 ---------------------MFFIKMLRQFSRIGKL-YWLSEKKWQAIALLFLLLC--LSLIG----TVVTVVLSLFL- 51 Nostoc sp. PCC 7120 17230155 1 ------------------M-NLGNPQIWQQFWQIIQP-YWLYRWRGDAIAQLIMLVI--LSLGS----SYFIIFEILQR- 53 Nostoc sp. PCC 7120 13470735 6 RRSQESVPDRLHRGPAGrS-HLTPVSSMRSFWGLMKA-YWFSERWKEAWTLTVVIAL--LTALS----SKAGVWFALAL- 76 Mesorhizobium loti
6325110 93 ykfpwkrrnrrpliRRtrsqmqldsgarimyipevelvdrqspddnkfmnatdkkkrkrifippkdndvyehdkflfknv 172 baker's yeast 17989321 68 --------------GH---------------------------------------------------------------- 69 Brucella melitensis 1175812 83 --------------NG---------------------------------------------------------------- 84 Haemophilus influenzae 15828127 92 --------------KD---------------------------------------------------------------- 93 Mycobacterium leprae 2492589 93 --------------ND---------------------------------------------------------------- 94 Mycobacterium tuber... 2492589 93 --------------ND---------------------------------------------------------------- 94 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 52 --------------GE---------------------------------------------------------------- 53 Nostoc sp. PCC 7120 17230155 54 --------------GE---------------------------------------------------------------- 55 Nostoc sp. PCC 7120 13470735 77 --------------GE---------------------------------------------------------------- 78 Mesorhizobium loti
6325110 173 eleraknsqlfYSKFLNQMNVlskili--ptvfdkNFLLLTAQIFFLVMRTWLSLFVAkldgqivkniiagrgrsflwdl 250 baker's yeast 17989321 70 -----------LMNSIVNVNT--------------APVQSPLAAVVTNAGVLIILILAkdvl------------------ 106 Brucella melitensis 1175812 85 -----------LYSSMQELNI--------------EKFWFFAKLNALLVVAQVIHAIA---------------------- 117 Haemophilus influenzae 15828127 94 -----------LYNALQAAFEgagaqndlvkqsgmHGFWMSLGIFSILAVIFIARVMA---------------------- 140 Mycobacterium leprae 2492589 95 -----------MYTALQKAFEgiasgdgtvkrsgvRGFWMSIGVFSVMAVLHVTRVMA---------------------- 141 Mycobacterium tuber... 2492589 95 -----------MYTALQKAFEgiasgdgtvkrsgvRGFWMSIGVFSVMAVLHVTRVMA---------------------- 141 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 54 -----------LESSLAAVDS--------------NRFIQAVVIFLGILLIGVPILAL---------------------- 86 Nostoc sp. PCC 7120 17230155 56 -----------ITSSLAAQNF--------------NRFYQTFWFFSGVVIINVIFISL---------------------- 88 Nostoc sp. PCC 7120 13470735 79 -----------LGNSIAFFHD--------------AANTSPLQAILTNAGILVLLVVLkdag------------------ 115 Mesorhizobium loti
6325110 251 gcwfliavpasytnsaIKLLQRKLSLNFRVNLTRYIHDMYLDKRlTFYKLIFDAk--aSNSVIKNIDNSITNDVAKFCD- 327 baker's yeast 17989321 107 ------------lvgfRHLLSTTLHRKWRKWLNDSFSDALLDRN-HTHFHLQQGn---GAHLPDNVDQRVQESIKGMTG- 169 Brucella melitensis 1175812 118 ----------------DYFFQQVFEIRWLESFNATLVKRWLNKK-KYYRLKYER------DLPDNIDQRIEQDAREFIT- 173 Haemophilus influenzae 15828127 141 ----------------DIYLTQRFIIAWRMWLTNHLTTDWLDQR-AYYREQFID------NTIDNPDQRIQQDIDIFTAg 197 Mycobacterium leprae 2492589 142 ----------------DIYLTQRFIIAWRVWLTHHLTQDWLDGR-AYYRDLFID------ETIDNPDQRIQQDVDIFTAg 198 Mycobacterium tuber... 2492589 142 ----------------DIYLTQRFIIAWRVWLTHHLTQDWLDGR-AYYRDLFID------ETIDNPDQRIQQDVDIFTAg 198 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 87 ----------------KTYLQAQLSLSWRQWLTTYFLNKYLHQR-NFYHLTTT-------SDIDNPDQRIAEDIQNFTQ- 141 Nostoc sp. PCC 7120 17230155 89 ----------------KNYIQAQISLDWRKWLTSDYFQQYFAKQ-SFYQLQVN-------AEIDNPDQRLAEDIKNVTQ- 143 Nostoc sp. PCC 7120 13470735 116 ------------ftgvRGLVSATLHRKWRGWLNSQFNKALLDGN-HTHFHAQHGsaagGIVAPDNIDQRIQESIKDMTG- 181 Mesorhizobium loti
6325110 328 -----------ATCSVFANIAKPVIDLIFFSVYLRDNLG-T--------VGVAGIFVN----YFITGFILR--KYTPPLG 381 baker's yeast 17989321 170 -----------GAIGLVMGIVGVVLSAFFVGQKLLEISTeVhgleflgsYGGALLALAvillYVPLGTLIAi-KIGKRLE 237 Brucella melitensis 1175812 174 -----------STVQIVRGVINSVLTTIEFTIILWSLSGvLtl----fgFNIEKGVVFfiyaFIIFATLMSv-WIGRPLI 237 Haemophilus influenzae 15828127 198 aggtpngpsngTGSTLLFGAVESVISVISFTAILWNLSGrLav----feFEIPRAMFWivivYVLLATIITf-WIGRPLI 272 Mycobacterium leprae 2492589 199 aggtpnapsngTASTLLFGAVQSIISVISFTAILWNLSGtLni----fgVSIPRAMFWtvlvYVFVATVISf-IIGRPLI 273 Mycobacterium tuber... 2492589 199 aggtpnapsngTASTLLFGAVQSIISVISFTAILWNLSGtLni----fgVSIPRAMFWtvlvYVFVATVISf-IIGRPLI 273 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 142 -----------QSLYFAIVLLDSILQLIAFSGVLW---------------RIAPTLMVfliiYAVVGTVFTtiVFGKTLV 195 Nostoc sp. PCC 7120 17230155 144 -----------RLVALFVIFLDSLVQLIGFIGVLW---------------LISPFLMYslvtYAVVGTLVTtlVFGKVLV 197 Nostoc sp. PCC 7120 13470735 182 -----------GAIGLAMGVLGVATSLYFIGENLIGSSVeVkgleflggYGSAVLAFLavaiYVPLNTWIAv-KLGRLLE 249 Mesorhizobium loti
6325110 382 KLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTKVKELYDVLMEkmllvdkvkfGYNMLEDYVLKYTWSGLGYVF 461 baker's yeast 17989321 238 RLNLGMQKAEGSYRGEWTTLLRRSFQISASEGENVQRTVNNRLYREVDG----------TWDKLNRFDAAYLAFSQAYGF 307 Brucella melitensis 1175812 238 KLNFTKEKLNGDYRYSLIRVRDNAESIAFYNGEPKEQTFLQHQFRQIIH----------NRWSIVLKMLGLNSFNSGVTR 307 Haemophilus influenzae 15828127 273 GLNFANEKLNAAFRYALVRLRDAAEAVAFYRGEEAERKQLEQRFTPIID----------NYRRYVSRTIRFLGWNASVSQ 342 Mycobacterium leprae 2492589 274 WLSFRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVID----------NYRRYVRRSIAFNGWNLSVSQ 343 Mycobacterium tuber... 2492589 274 WLSFRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVID----------NYRRYVRRSIAFNGWNLSVSQ 343 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 196 GINFEQLKREADLRYGLIRVGDNAEAIAFYQGQAVESQEIWQRFLRVVS----------NFTHLIRWQLGLDLFQNSYQY 265 Nostoc sp. PCC 7120 17230155 198 GINLEQIKREADFRYGLVRVRENAEAIAFYNGQTQESQQLKQRFSQVFA----------NIKRLISWQFRLNVFQNGYQF 267 Nostoc sp. PCC 7120 13470735 250 RLNIRMQQAEGSYRSELTTFLRRSFHVAASHGEDVQKSMHDKLYVDIDK----------TWGKLNVVNNGYTSFELIYNF 319 Mesorhizobium loti
6325110 462 ASIpIVMSTLATGInseeknmkeFIVNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFnygavpS 541 baker's yeast 17989321 308 LSLrIVAYIPGFLP---------YMSGAVNFRNYVTGAELVAAMINDCSWFIQVMPAIANLRANAGRVIGLAQ------S 372 Brucella melitensis 1175812 308 VAK-LLPLMLQAPR---------FFSGQIKLGDMHQTVQAFNRLMTALSFFRLFYEQFTLYQARLNRLYGFIT------K 371 Haemophilus influenzae 15828127 343 TIV-PLPWILQAPR---------LFAGKINLGDVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRLHGLVV------A 406 Mycobacterium leprae 2492589 344 TIV-PLPWVIQAPR---------LFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIRLHGLVD------A 407 Mycobacterium tuber... 2492589 344 TIV-PLPWVIQAPR---------LFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIRLHGLVD------A 407 Mycobacterium tuber... 15678005 -------------------------------------------------------------------------------- Neisseria meningiti... 17230142 266 ITF-LLPTFILAPR---------ILAGELEIGVSAQAGVAFRSILLALGLIISQFEQLSNLAAAVTRLDELYN------L 329 Nostoc sp. PCC 7120 17230155 268 LTF-ILPFLILAPR---------IFSRELEIGAVTQSQAAFERVGLALGLIITQFNQITTLAAGVERLSELG-------- 329 Nostoc sp. PCC 7120 13470735 320 LGArIVAYGPGLVS---------FIHNRLDYKGYITGSEMVAQLISQCSWFIHVMPAIATLRANSQRVTELAN------A 384 Mesorhizobium loti
6325110 542 ILSIRTEDASRNSNLlPTTDNSQDAiRgtiqrnfNGIRLENIDVIIPSVRasegiKLINKLTFQIPlhidpitsksnsiq 621 baker's yeast 17989321 373 IESVQEPAEFYARSGvNRFAFTHQHpR-------FGLSVRNLTLMQGPASe---tPFLRSGVINMR-------------- 428 Brucella melitensis 1175812 372 MDELD-KQNVHHPFH-------C---S-------HRVALKNFGIKDEQGH-----VLLNNLNINLE-------------- 414 Haemophilus influenzae 15828127 407 NARSRELPHVTAKST-------N---D-------GTVHVVAVEVRTSAGE-----QLIDPLDLQLN-------------- 450 Mycobacterium leprae 2492589 408 NEKGRALPAVLTRPS-------D---D-------ESVELNDIEVRTPAGD-----RLIDPLDVRLD-------------- 451 Mycobacterium tuber... 2492589 408 NEKGRALPAVLTRPS-------D---D-------ESVELNDIEVRTPAGD-----RLIDPLDVRLD-------------- 451 Mycobacterium tuber... 15678005 1 ---------------------------------------------------------MSGININLK-------------- 9 Neisseria meningiti... 17230142 330 I----EKLENPINLNqEQYIILNRLaD-------SYISFQNVTLHTPDYQk----ILVKDLSFTVS-------------- 380 Nostoc sp. PCC 7120 17230155 330 -----K------AMQtEAQGKIKFAeN-------TEINIKNLTLEIPE-Rg----NLIQDISLSVK-------------- 372 Nostoc sp. PCC 7120 13470735 385 IENVQHPQAFYSQTGqSDFHYASQNpV-------FGLTIQKLELAHQGEDa---tPFLSAANLRFR-------------- 440 Mesorhizobium loti
6325110 622 dlskandiklpflqgSGSSLLILGPNGCGKSSIQRIIAEIWPVYNknGLLSIP-SENNIFFIPQKPYFSRGgTLRDQIIY 700 baker's yeast 17989321 429 ---------------AGDWIYMRGESGSGKTSFIKALNGLWPYGT--GNIIYP-QGANSLYVPQEAKFPSV-SLKQLVAL 489 Brucella melitensis 1175812 415 ---------------NGDALLIQGASGTGKTSLLKAIAGIYPFET--IG-IAEhPCMGSLFLPQRPYMPQG-TLREAICY 475 Haemophilus influenzae 15828127 451 ---------------CGSSLVITGRSGVGKTTMLRSLAELWPYAS--GTLSRPdGKNETMFLSQLPYVPLG-NLRGVVCY 512 Mycobacterium leprae 2492589 452 ---------------RGGSLVITGRSGAGKTTLLRSLAELWPYAS--GTLHRPgGENETMFLSQLPYVPLG-TLRDVVCY 513 Mycobacterium tuber... 2492589 452 ---------------RGGSLVITGRSGAGKTTLLRSLAELWPYAS--GTLHRPgGENETMFLSQLPYVPLG-TLRDVVCY 513 Mycobacterium tuber... 15678005 10 ---------------NGDSLLIRGPSGCGKTSLLRALAGLWPFGS--SGKVSRpPHQDILFLPQRPYTAQG-SLRDAVCY 71 Neisseria meningiti... 17230142 381 ---------------PGESLLITGKSGVGKTSVLRALAGLWQSGT--GKITYPkSH--LLFLPQRPYMILG-SLREQLLY 440 Nostoc sp. PCC 7120 17230155 373 ---------------PGESLIIVGESGVGKTSLLRAIAGLWLHGE--GIIERPaNDS-LLFLPQRPYITWG-SLRQQLTY 433 Nostoc sp. PCC 7120 13470735 441 ---------------RGEWTFLKGESGCGKTSLIKAINGLWPYGR--GTIVFP-DGVKSFYAAQEVKLQQV-SLKQLVCL 501 Mesorhizobium loti
6325110 701 PMSSDeffdRgFRDKELVQILVEVKLDYLLKRgvgltyLDAIAD----WKDLLSGGEKQRVNFARIMFHKPLYVVLDEAT 776 baker's yeast 17989321 490 PRDEG----D-FNDLAVAAVLHEAGLGEFIER------MKDADAgnspWDMVLSGGQKQKVMLARILLHKPSIIFLDEAT 558 Brucella melitensis 1175812 476 PNIN-------PSHAELEQTMKDCALGKYIHA------LNVKND----WQAILSPGELQRVAFIRILLTKPDVVFLDETT 538 Haemophilus influenzae 15828127 513 PNAP-----AdIPEDTVRDTLTKVALNPLCDR------LDEERD----WAKILSPGEQQRIAFARILLTKPKAIFLDEST 577 Mycobacterium leprae 2492589 514 PNSA-----AaIPDATLRDTLTKVALAPLCDR------LDEERD----WAKVLSPGEQQRVAFARILLTKPKAVFLDEST 578 Mycobacterium tuber... 2492589 514 PNSA-----AaIPDATLRDTLTKVALAPLCDR------LDEERD----WAKVLSPGEQQRVAFARILLTKPKAVFLDEST 578 Mycobacterium tuber... 15678005 72 PDID-------KQHPELAEAMNTCRLGYLVDK------LDKTDD----WQHKLSPGELQRVAFVRALLSKPKIVLLDEAT 134 Neisseria meningiti... 17230142 441 PQNNR----S-ISDDELLQVLQQVNLTDLIER------FNGLDSit-dWERVLSVGEQQRLAFARLLIQSPQYAILDEAT 508 Nostoc sp. PCC 7120 17230155 434 PQTTT----N-IPSEILLKTLQQVHLPDLAQS------HGGLDTvi-dWSRVLSLGEQQRLAFARLLLIQPKYAILDEST 501 Nostoc sp. PCC 7120 13470735 502 PGSEH----D-HGDAQVASALHKAGLGDFIEH------MANESRegksWDQVLSGGQKQKLVVARIILQQPGLLFLDEAT 570 Mesorhizobium loti
6325110 777 NAISVDMEDYLFNLLKR--YRFNFISISQRPTLIKYHEM---LLEIGENRDGkwqlQAVGTDEAITSI 839 baker's yeast 17989321 559 GALDPASKLRFHTALKTrcPDAIVVSIMHEEKLPTLESGesiFSHVLDIANG----YVSLIPAHFAAA 622 Brucella melitensis 1175812 539 SALDETTENLLYQTIKErlPEMIILSVGHRSTLQQFHNK---QLKLDVCLLC----EN---------- 589 Haemophilus influenzae 15828127 578 SALDEGLEFALYQMLRSelPDCIIVSVSHRRAVELLHAQ---QLELLGGGQW----RLGPVEKEPLHV 638 Mycobacterium leprae 2492589 579 SALDTGLEFALYQLLRSelPDCIVISVSHRPALERLHEN---QLELLGGGQW----RLAPVEAAPAEV 639 Mycobacterium tuberculosis 2492589 579 SALDTGLEFALYQLLRSelPDCIVISVSHRPALERLHEN---QLELLGGGQW----RLAPVEAAPAEV 639 Mycobacterium tuberculosis 15678005 135 AALDEPTEALLYRALKQklPDSIIISIGHRSTLNAFHNM---RLDVGNVACG---------------- 183 Neisseria meningitidis MC58 17230142 509 SALDETNQTQLYQQLQT--TQITYISVGHRSSLRPFHHH---ILELIKPprpfa-------------- 557 Nostoc sp. PCC 7120 17230155 502 SALDEETEASLYQQLQQ--TSITYISVGHRNTLLNYHQM---VLELAQQNWQ----LLPIDNFCFAQR 560 Nostoc sp. PCC 7120 13470735 571 GALDPEGKIAFHQAIKDncPDVTVISVMHEAVAPRSAAGtefYHSIVLIADG----VATKKPLTPTLP 634 Mesorhizobium loti
Jiyao W et al.(2023). "The conserved domain database in 2023.",