2BI0


Conserved Protein Domain Family
FkbR2

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cd03451: FkbR2 
Click on image for an interactive view with Cn3D
FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.
Statistics
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PSSM-Id: 239535
Aligned: 39 rows
Threshold Bit Score: 110.372
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on the active sites of (R)-hydratase and the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #    # #  #               #  ##                    
2BI0_A       12 GPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIVGNRLRLALDSDLCAAvtgXPGPLAHPGLVCDVAIGQSTLAtqr-vkA 90  Mycobacterium tu...
NP_422450     7 GNYFEDFRLGQRLVHATPRTVTAGDVALYTALYGPRFSLFSSDAFAQGc-gLMSAPVDPLIAFHVVFGKTVPDislnavA 85  Caulobacter cres...
NP_712808    29 GRYLEEFTEGEIFEHPREITIDRAFAQEFATTFMDANPLFLSAPYAKAh-gFQDMLVSSLQVFNIALSLGVQNdsekalA 107 Leptospira inter...
AAK25618    192 PHAFEDYAIGEKIDHVDGMAVEEAEHQMATRLWQNTAKVHFNQFERAKd-pSGRRLVYGGVVISTAKALSFNGlqn-agL 269 Caulobacter cres...
ZP_00767844   8 GNFFEDFRLGQTIVHATPRTITEGDVALYTSLYGSRFALTSSTPFAQSl-gLERAPIDSLLVFHIVFGKTVPDislnaiA 86  Chloroflexus aur...
ZP_00767844 193 NYLWDDYEVGEKIDHVDGVTIEEAEHMQATRLYQNTARVHFNLHVEREg-rFGRRIVYGGHIISLARSLSFNGlan-alS 270 Chloroflexus aur...
ZP_00599349   7 GNYFEDFRVGMKIRHATPRTLTEGDRSLYIGLTGSRAALCTAETNARDl-gMERRPLEDLLVFNTAFGKTVPDislnavA 85  Ralstonia metall...
ZP_00054946 198 PHLWDDYAVGEKIDHVDGMTIEEAEHMMATRLWQNTAKVHFNQYTEGQg-rFGRRLIYGGHIISLARALSFNGlgn-afK 275 Magnetospirillum...
ZP_00554115   7 GYFFEDYHVGQSLHHATSRTLHDGDVAMYQALYGPRFALQSSWDFASPgssLRNPVMDDLITFHTVFGKTVPDislnavA 86  Jannaschia sp. CCS1
YP_135394   241 LERADTENAAVAYRHERGRTMDDQLVAGLPLATLNTARQHHNRDEMADs-pSGDIVAYGDVTRSVALAHARSDea--tyR 317 Haloarcula maris...
Feature 1                                                                                       
2BI0_A       91 NLFYRGLRFHRFPAVGDTLYTRTEVVGLRanspkpgrAPTGLAGLRXTTIDRT---------------DRLVLDFYRCAX 155 Mycobacterium tu...
NP_422450    86 NLGYAEGRFLAPVFPGDTLSAVSDVIGLKen----snRKTGVVYVRTTGVNQR---------------GEPVLSYVRWVM 146 Caulobacter cres...
NP_712808   108 NLGYYNVQFLKPVYPGDTLSAKTKILKVDdk----gsDKPGIVSVRTICLNQN---------------KELVLQYERKIM 168 Leptospira inter...
AAK25618    270 ILAINGGRHVAPFFAGGTVFAWSEVLDKAd------lGAVGALRLRLVATKDRpcddfpdkdaegaynPAVILDFDYWAA 343 Caulobacter cres...
ZP_00767844  87 NLGYAGGRFGAVVYPGDTLSTTSKVIGLRqn----kdGKTGVVYVHSVGVNQW---------------DEVVLEYIRWVM 147 Chloroflexus aur...
ZP_00767844 271 IAAINSGRHTNPSFAGDTIYAWSEILAKMaip---grTDIGALRVRTVATKDRpchdfpyrdaegnydPAVVLDFDYTVL 347 Chloroflexus aur...
ZP_00599349  86 NLGYAEVRFLAHVYPGDTLAVESEVIGLKen----tsGKSGVVYVRSMARNQH---------------GREVLSWVRWVM 146 Ralstonia metall...
ZP_00054946 276 IVAINGGRHTNPTFAGDTIHAWTEVLEKIevp---grKDVGALRLRLVATKNCl-------------aPLPPQGGKRXGF 339 Magnetospirillum...
ZP_00554115  87 NLGYAEGRFLARVESGDTIHARSEIIGLKqn----snGKTGIVWVRTRGFSNV---------------DVPVLEYVRWVM 147 Jannaschia sp. CCS1
YP_135394   318 ERRFADEQFHDFVTLGDTVYGFTRVLDCDpda---gpERAGAVTFEHVAFNQD---------------QTPVYSGRRTAL 379 Haloarcula maris...
Feature 1            
2BI0_A      156 LPASP 160 Mycobacterium tuberculosis
NP_422450   147 VRKRD 151 Caulobacter crescentus CB15
NP_712808   169 IYRSN 173 Leptospira interrogans serovar lai str. 56601
AAK25618    344 VPKRG 348 Caulobacter crescentus CB15
ZP_00767844 148 VRKRD 152 Chloroflexus aurantiacus J-10-fl
ZP_00767844 348 MPRRG 352 Chloroflexus aurantiacus J-10-fl
ZP_00599349 147 VHKRD 151 Ralstonia metallidurans CH34
ZP_00054946 340 RRQRG 344 Magnetospirillum magnetotacticum MS-1
ZP_00554115 148 VRKRD 152 Jannaschia sp. CCS1
YP_135394   380 IQRDT 384 Haloarcula marismortui ATCC 43049

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