2QAG,2QAG,2QAG


Conserved Protein Domain Family
CDC_Septin

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cd01850: CDC_Septin 
Click on image for an interactive view with Cn3D
CDC/Septin GTPase family
Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.
Statistics
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PSSM-Id: 206649
Aligned: 65 rows
Threshold Bit Score: 279.816
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:2QAG: Human Septin binds GTP; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #######                                                             
2QAG_C     28 RGFEFTLMVVGESGLGKSTLINSLFLTDLYSpey----------------------------pgpSHRIKKTVQVEQSKV 79  human
CAI38985   57 KPIYLNIMVVGQSGLGKSTFIDVLLKKKLGTgq------------------------------iiRDSTLQIQEIQGQIY 106 Paramecium tetraur...
NP_011975  31 EGGTFTVMLCGESGLGKTTFINTLFQTVLKRadgqq------------------------hrqepIRKTVEIDITRALLE 86  baker's yeast
CAD25010   22 AGIDFNIMTVGSNGLGKSSFINQMLGDSILSsdpflkpedghhsnetvraldedivddpeskyfhRNSLINIQISKFFVM 101 Encephalitozoon cu...
XP_444875  26 AGSVFNMLVCGESGLGKTTFINTLFPGLKQRkg-------------------------------kKVSTEAVDIVRAQLT 74  Candida glabrata C...
XP_447306  21 DGGVFNMMVCGESGLGKTTFVNTLFSTTLKStedhp-------------------------rdnaIRKTVRINISRAILE 75  Candida glabrata C...
XP_451892 146 NGVQFTMMVVGQSGLGKTTFINTLFGTSLLPtvwesd-----------------------mtergVTKTTKIVRHESELV 202 Kluyveromyces lact...
AAW42225   21 RGAHFTIMVVGQSGLGKTTLINTLFATEICSprnyrq-----------------------rfakqLDKTTEVEILKADLE 77  Cryptococcus neofo...
XP_722568 114 MGGKFSLMVAGARGTGKSSFVNCLFGNELLVen------------------------------cdTANREFLDINHFELI 163 Candida albicans S...
XP_759746  22 AGGHFTLMVVGESGVGKTTLINTLFSTELATgkdhtr-----------------------rhtkqLDKTVEIDIIKAELE 78  Ustilago maydis 521
Feature 1                   #  #                                                              
2QAG_C     80 LikegGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNR---------RQMPDNRVQCCLYFIAPSG 150 human
CAI38985  107 Nn---DLSLNIKFIDTPGFRHQYGLRSWLKLLSTYIHNQFNTYKLRQTQQYEskekfqqlsQQDLDERVHVCLYFFSGPR 183 Paramecium tetraur...
NP_011975  87 Ek---HFELRVNVIDTPGFGDNVNNNKAWQPLVDFIDDQHDSYMRQEQQPYR---------TKKFDLRVHAVLYFIRPTG 154 baker's yeast
CAD25010  102 En---DFQTRVTVTEVDGVGDGVCNEGCWDPIVELIQDNFRDYLDQERKNVR---------SLIKDKRIHICLYFLEPNP 169 Encephalitozoon cu...
XP_444875  75 Ek---GFTMRFNVVDTPAFGDKVDNNRAWQPVVDFIDDQYDSYLRQEQQPFR---------DVRFDFRVHAVLYFIRPTA 142 Candida glabrata C...
XP_447306  76 Es---DFSLRVNVIDTPGFGDNINNDKAWQTVVDFIDDQHDSYMRQEQQPFR---------DTKFDLRIHAVLYFIRPTG 143 Candida glabrata C...
XP_451892 203 En---GFTLRYTVIDTPGFGDLANNNFSWSPIVNYIDEQYRSYIFQEEQPLR---------ASLKDNRIHCCLYFINLTR 270 Kluyveromyces lact...
AAW42225   78 Er---GFNIKLTVIDTPGFGDYVNNRDSWGPIVDFIDDQHESYMRQEQQPFR---------KEKQDLRIHACLYFIKPTG 145 Cryptococcus neofo...
XP_722568 164 En---GFTLNLQIIETVNYGNFFDKGFKSDSLCAFVDEKFKAFLYQSRQPRR---------ESLIDSRVHCCVYFLTQTV 231 Candida albicans S...
XP_759746  79 Ek---QFKVKLTVIDTPGFGDYVNNRDSWTPIVDFIDDQHELYMRQEQQPER---------RDKTDLRVHACLYFIRPTG 146 Ustilago maydis 521
Feature 1                             ## #                                                    
2QAG_C    151 HGLKplDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEfpetddee--------------enk 216 human
CAI38985  184 IQAE--DLQALKKISGLVNVIPILAKGDSYTKNEIIQLKQQFNDLISEYHIDLFKcqcnns-----------------yq 244 Paramecium tetraur...
NP_011975 155 HGLKpiDIETMKRLSTRANLIPVIAKADTLTAQELQQFKSRIRQVIEAQEIRIFTppldadskedaksg--snpdsaave 232 baker's yeast
CAD25010  170 SHVSlvDIRTMKEISKICNLIPVVGKSDLLSDSEREECRNRIVEVLSMENIDVFRldile-------------------- 229 Encephalitozoon cu...
XP_444875 143 HGLKplDIWTMKHLSQRCNLIPVISKADTLTAQELQLFKSRIRQVIEAQEIAIFTppldytdgaegaagsldeanapale 222 Candida glabrata C...
XP_447306 144 HGLKpiDIETMKRLSSRANLIPIISKSDTLTQNEITEFKNRIRQVLEYHQIRIFTppleeaadqsnk------qdmisfe 217 Candida glabrata C...
XP_451892 271 NGLSalDIAAMEEISKRVNLIPVIAKIDGLTSADLEMYKRKIRETLQKQEIKVCSfldqnh------------------p 332 Kluyveromyces lact...
AAW42225  146 TTLKplDVEIMKKLGTRVNLIPVIAKADTMTPEDLHNFKTIVRETVIAQNISVYTppvdldde-------------aaae 212 Cryptococcus neofo...
XP_722568 232 NSISdlDIQTMKKLSTRTNLIPVVAKADMLTEIELHNFKNLVKTTLEKHEIETCQsisne-------------------k 292 Candida albicans S...
XP_759746 147 HTLKplDIETMKRLGTRVNLIPVVAKADTLTQTDLAVFKQRIREVISTQNIRVYSppvevdda-------------asad 213 Ustilago maydis 521
Feature 1                   ##                                                                
2QAG_C    217 lvkkIKDRLPLAVVGSNTIievn---gkrVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHmqDLKDVTNNVhYENYRSR 293 human
CAI38985  245 ekgqFGITPPYVIISSIEQfqvg---nhfIYGRKFPWGICDIFNPQHSDLSILYKLLIGHYcfELISLTEYL-YNKYEQK 320 Paramecium tetraur...
NP_011975 233 harqLIEAMPFAIVGSEKKfdng--qgtqVVARKYPWGLVEIENDSHCDFRKLRALLLRTYllDLISTTQEMhYETYRRL 310 baker's yeast
CAD25010  230 kekiSRTESPFFIIAKNVNsgd-----ssGHNREYPWGTMFPEKVESNDFYFLVDSLIAKNliRLVETTEVF-YDEYKTR 303 Encephalitozoon cu...
XP_444875 223 harqLIESMPFAIVGSEDRydng--sgtmVLARKYPWGLVEVENDEHCDFRKLRALLLGTYmlDLITSTEQThYENYRRT 300 Candida glabrata C...
XP_447306 218 harsIIEAMPFHIVGSDKQyqna--agqmVTARKYPWGLVEVENEAHCNFVLLRTLLLRTYlaDLIETTNEIhYETYRRL 295 Candida glabrata C...
XP_451892 333 ncqtIFDTYPFGIVCSDEMvtnn--egklVRGRKYKWGNVEVENPLHSEFTALRTVLMSKNlvDFAVGCENY-YEKCRSH 409 Kluyveromyces lact...
AAW42225  213 haraMQAVMPFSIIGSTQDvttp--dgrvVKGREYLWGVAEVENEDHCDFKKLRSLLIRTYmlDLITSTEEKhYEAYRLA 290 Cryptococcus neofo...
XP_722568 293 lvqeISMKIPLSVISSSSSpseinnngkiDRVRKYPWCLLDIENESWCDFHYFRKLLLEENmlEFVASTEVY-YEQFRNN 371 Candida albicans S...
XP_759746 214 haklLMSAMPFSIIGSTDDvrtg--dgrvVKGREYLWGVAEVENEDHCDFKKLRSLLIRTHmlDLINTTEELhYENYRQA 291 Ustilago maydis 521
Feature 1           
2QAG_C    294 KLAAVT 299 human
CAI38985  321 EKEKLK 326 Paramecium tetraurelia
NP_011975 311 RLEGHE 316 baker's yeast
CAD25010  304 EIGLSI 309 Encephalitozoon cuniculi GB-M1
XP_444875 301 RLEGIN 306 Candida glabrata CBS138
XP_447306 296 RLEVGL 301 Candida glabrata CBS138
XP_451892 410 ILLSRI 415 Kluyveromyces lactis NRRL Y-1140
AAW42225  291 QMETRK 296 Cryptococcus neoformans var. neoformans JEC21
XP_722568 372 FLSGNI 377 Candida albicans SC5314
XP_759746 292 QMETRK 297 Ustilago maydis 521

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