Conserved Protein Domain Family
SAP25
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pfam15476: SAP25 
Histone deacetylase complex subunit SAP25
SAP25 is a family of proteins found in eukaryotes. SAP25 is a core component of the mSin3 co-repressor complex whose subcellular location is regulated by PML. mSin3, the transcriptional co-repressor, is associated with histone deacetylases (HDACs) and is utilized by many DNA-binding transcriptional repressors. SAP25 is a nucleo-cytoplasmic shuttling protein that is actively exported from the nucleus by a CRM1-dependent mechanism. It binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA.
Links
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Statistics
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PSSM-Id: 406038
Aligned: 9 rows
Threshold Bit Score: 250.208
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ELK06931     248 MTLLAPWDPNYEAKAGPGLLWGPSCGSGASFSGRTLGHPSFWPLYEaASGRGHRPLA---PTIGHQ-------NGK-QVP 316
EHB13480       1 MTLFSPWDPNFGAKARPQPVWTPSCGPGASFSGRTLCHPSFWPMYE-AWGRGRRHQA---PSLGCQ-------NGQ-QAP 68 
XP_007617540  96 MTPLPLWDPIHEANARPQLV-GPSCGSGASLSGRTLCHPS-WPMYD-DWGRV--------PTSGHP-------EEA-QVS 156
XP_023614306 128 MTLLAPWDPNYEAKAGSQLVWGPSCASGASFSSRTLCHPSFWPLYEaASGRARRPLT---SAAVHQ-------SGE-QAP 196
XP_014332900   1 MALLAPWDPNYEATAGRRLVWGPSCASGVSFSGRTLYHPSFWPLYQaASCRGLRP-----SLAGHR-------GEE-QAP 67 
ELW56482      97 MTLLAPWDPNYHAKAGPRLMWEASCGSGASFSSRTLCHPSFWPLYEaASSRVLRPLA---PTTGHQ-------NGDnQAP 166
3_pfamImport   1 MTLLAPWDPNYQAKAGPRLVWGASCGSGASFSGRTLCHPSFWPLYEaSSSVGVRPRTfrnPGTGPQ-------NGE-WAV 72 
XP_019663566  10 MTMLAPWDPNYKATAGPRLVWGPSCASGASFSGRTLCHPSFWPLYEaASGRELRPLV---PTTGHQ-------NGE-HAP 78  giant panda
XP_005328637  92 MTLLSPWDPNYEAKPRPRLVWGSSCGSGASFSGRTLCHPSFWPMYE-VSGRAARP----------LaptpghqNEE-QSP 159 thirteen-lined ...

ELK06931     317 RDAGFPVMCCEDVFLSDPLLPCGQRVPLYLSEAPQQVMGSPKLLLPPPIMSPRVCPTQSPGCSTAWLSGPELIALTGLLQ 396
EHB13480      69 RDAGFPVMCSEDVFFLDPLLPPGQHVPLYLSEAPQQALGSMKLQLPPPIMSPSVYPSQPRGCCMAQLSGPELIAITSLLQ 148
XP_007617540 157 KDTGLPVTGYEDVFLLDPLLPCGQRVPLYLSKPPQQAVGTRKLLLPPPIMSSSVRPSSSQACSSTWLSEAEMIALTGLLQ 236
XP_023614306 197 RDAGFPVMCCEDVFLSDPLLPPGQRVPLNLPEAPQQVMGSLKLLLPPPIMSPQVCPTPSPGCCTAWLSGPELIALTGLLQ 276
XP_014332900  68 RTAGFPVMCSEDVFFLDPLLPHGQRVPLYLSEVPQQVMGSLKLLLPRPIMSPWLLPIPSSGCSTTWLSGPELIALTGLLQ 147
ELW56482     167 RDAELPVMCHEDIFLSDPLLPCGQRVPLYLSEAPQQVMGSMKLLLPPPVMSPWVHPTPSRGRSTAWLSGPELIALTGLLQ 246
3_pfamImport  73 QDTGFSVMCREDVFLCDPLLPCGQRVPLYLSEAPTAVMGSLKLLLPPPVMSPWVVPSRSQSCSTAWLSGPELIALTGLLQ 152
XP_019663566  79 RDAGYPVMCCEDVFLSDPLLPCGQRVPLYLSEASQQVMGSLKLLLPPPIMSPWVLRTPSPGCSTAWLSGPELIALTGLLQ 158 giant panda
XP_005328637 160 RDAGLPVMCCEDVFLLDPLLPCGQRVPLYLSEPPQQNMSSLKLLLPPPIMSPSVCPSASQGCSTAWLSGPELIALTGLLQ 239 thirteen-lined ...

ELK06931     397 MSQGEPRPSFSGssmAPTPFAG--PPDPIS---NHPRPSGDpscphcTDPSLPWTPDTHCP 452
EHB13480     149 MSQGEPRPGSSG---APPSPAG--PLEPIS---DHQSSSGS------TDPSLPRPSDTHCP 195
XP_007617540 237 MSQGELRPNSLA---SPLTSTScqDPGSAS---EDPGPSGGqscsgsTDACPTQTPDTHCP 291
XP_023614306 277 MSQGEPRPSSTGslaAPTPPSG--PLDPVS---DHAGPSGsh----gTDPSLPQTPETNCP 328
XP_014332900 148 MSQGEPRPSSSG---APGLPSG--SPAPAS---DHPAASGGpgcshcGEPSLPGTPDVQGP 200
ELW56482     247 MSQGEPRSSLAS---SSIPSAG--TSDPVS---DHPGPSDDqscfhcTDSSLPWDPDTHCP 299
3_pfamImport 153 MSQGEPRPNSSS---APAAPAG--LPDPISgqpDQSGSSGGpscshcTDPCLPWTPDTHCP 208
XP_019663566 159 MSQGAPRPASSG---APTAHAG--PPDPVS---DHPGPSGGpscshcTNPSVPRTPDAH-- 209 giant panda
XP_005328637 240 MSQGDPRPSSPP---ASPIPASctAPVPVS---DHPGPSGSqscsgnTD-----------P 283 thirteen-lined ground squirrel
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