1J1J,2QVA,4DG7,3RIU,3PJA,1KEY,3QB5,3AXJ,2QRX


Conserved Protein Domain Family
Translin

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cd14819: Translin 
Click on image for an interactive view with Cn3D
Translin, also known as TB-RBP (testis brain RNA-binding protein)
Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in drosophila. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.
Statistics
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PSSM-Id: 271349
Aligned: 85 rows
Threshold Bit Score: 128.803
Created: 2-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:3AXJ: Drosophila melanogaster translin-TRAX interatcions; contacts at 4.0A
  • Structure:3RIU: Drosophila melanogaster translin-TRAX interactions; contacts at 4.0A
  • Structure:1KEY: Mus musculus translin-TRAX interactions; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ## ##   #   #  #                                                                
1J1J_A        22 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHqgagfq------dipkrcLKAREHFGTVKTHLTSLKtkfp--- 92  human
3AXJ_A        27 YQKYIDNEQEVRENIRIVVREIEHLSKEAQIKLQIIHsdlsq--------isaacGLARKQVELCAQKYQKLAelvp--- 95  fruit fly
XP_002295219  40 YLTEIGSELRLTEQKRRSANDRSWELNAALVRVVMAHeasmepss---tnqdelvKEEESLDSLVKETVLSSAfydnivr 116 Thalassiosira p...
EMG49059       9 SIKDDIEQLNRKSSLQEIEHQFDLTLIPYKSIINEWIncspthlsssiiekgasgQTIYENYHKYKSLILDLDck----- 83  Candida maltosa...
EGW31868      11 IQDEIEKDLQQKSALQELEHQLDLKLIPHKNFINELSalnpqdlit-iptltspeIPIPEILDEFTTSLGKLDck----- 84  Spathaspora pas...
XP_003868381  11 IREEIAKDVNKKTLLQELENQFDLSLIPYQTTINSWTsispsrlnsvfqttnsfeCTIRENVEKFTNSLLELDck----- 85  Candida orthops...
EPY51937       9 LQTKIDHETSLRDELSSRVETIDQETKVLRLLLGEVEisnn-----------evsIDITRSTEVIKVKIQELAklas--- 74  Schizosaccharom...
EOQ99356      20 LNGFIEKDNEYKQSLKDRVAVMDESLHESTAIAQNIHsikqse------ipqsiiKPMESGLLQYAKDFHQLCseie--- 90  Wallemia ichthy...
EIM19609      13 LNVTIEKDNDYKQSLRDTVSLMDEHLQNAMANAQRIHttkqed------ikinviEPTTSCLKQFREFYLSEFankm--- 83  Wallemia sebi C...
Q9P7V3         9 LQDQIDKEHSIREKLTAEVDLLDEKLRVLQLLLANCEqnl------------enqEEILEALEIIKSKTRGLAelas--- 73  Schizosaccharom...
Feature 1                      ###                                                # ##           
1J1J_A        93 -----------aeqYYRFHEHWRFVLQRLVFLAAFVVYLet----------------------eTLVTREAVTEILGiep 139 human
3AXJ_A        96 -----------agqYYRYSDHWTFITQRLIFIIALVIYLea----------------------gFLVTRETVAEXLGlki 142 fruit fly
XP_002295219 117 dglgdmkteskahpRAPRLDSLSLKMEEYARYKAFRHFLse----------------------gNLLSPSAPCFVATegd 174 Thalassiosira p...
EMG49059      84 -------------pSQKERFLSKFLEDSIYILVANRYFLsiangfitdpie-ipmitntvsdvgVIMNPNEVAEILFldk 149 Candida maltosa...
EGW31868      85 -------------aVQKERLLNKSIEECAVLILAYRYYRsigecfntdgetvkvpmvsnshlvgTIGTPRELSHLLNlek 151 Spathaspora pas...
XP_003868381  86 -------------sSQKERLSNKFIEDSIYILLVNRYFWilatsfahdpik--vklittennlgIIATPQEIFQSLGird 150 Candida orthops...
EPY51937      75 -----------ehsYYKYVNVWDRTIQEVACLILLATWRgalrgh--------------edkkyQILTLEEVGQILNvpv 129 Schizosaccharom...
EOQ99356      91 -----------ptdYTKYEHIWNRSLQTFIYLNLLSNYLsh----------------------dDIIDYSTIKLMINnd- 136 Wallemia ichthy...
EIM19609      84 ----------sdieYLKYQHLWSRSIQTYMFIQLLLNYLqd----------------------eDLLTHKEFNEFTKyd- 130 Wallemia sebi C...
Q9P7V3        74 -----------nfpYYKYNGVWDRSIQKVVYLYLLASWTgrldks--------------lrptySLLSLSEVGQILQvpv 128 Schizosaccharom...
Feature 1                  ## ##  #                                         #  ### ## ##         
1J1J_A       140 dre-kgfhldVEDYLSGVLILASELSRLSVNSVTagd----------ysrPLHISTFINELDSGFRLLNLKNDsLRKRYD 208 human
3AXJ_A       143 sqs-egfhldVEDYLLGILQLASELSRFATNSVTxgd----------yerPLNISHFIGDLNTGFRLLNLKNDgLRKRFD 211 fruit fly
XP_002295219 175 eq---ravvtDEEYLGGCILLCHDLAKYGVSRATnavtdp-----davpaVQKARDIVSKVLEMLLEFDFRNGpLRRKYD 246 Thalassiosira p...
EMG49059     150 --------idYQSYLLALLRLVDTIVEYTTTTVInesvgssgaksanysiSIINSQIVSKLQNGFQLLDLKNDmLRKRYD 221 Candida maltosa...
EGW31868     152 --------idYQVYLLALLRVVDTIVDYTSSTVIrlsigsn--spkdytiAMINSEIVSKLQKGYQLLDLKNDiLRKKYD 221 Spathaspora pas...
XP_003868381 151 --------vnYQLYLIALLKLIDVVVEYTTTTVInqsigsttsqspnysiGIINSKIVSKIQNGFSLLDLKNDiLRKRYD 222 Candida orthops...
EPY51937     130 ypeevkfhisIEEYLHGVLSISSELARFSVNAVIhgn----------kevPLKSLQTIENVHSSFQLLSLKNDsLRRHFD 199 Schizosaccharom...
EOQ99356     137 --------nhLYDYLFALMQLVSELTRLTVNTVIlne----------fdrPKRISAFIKDVYQALSQLNFKNDaLRRKFD 198 Wallemia ichthy...
EIM19609     131 --------dhLYDYLFALISLVNELTRLTVNTVImne----------fdrPKRISAFLKDVYQGLSLLNFKNDaLRRKFD 192 Wallemia sebi C...
Q9P7V3       129 fpeestfhlsIEQYLHAVLSLCSELARQSVNSVIsgn----------yhiPFEALNTIQKVHSSFQVLSLKNDsLRRHFD 198 Schizosaccharom...
Feature 1                            
1J1J_A       209 GLKYDVKKVEEVVYDLSIRG 228 human
3AXJ_A       212 ALKYDVKKIEEVVYDVSIRG 231 fruit fly
XP_002295219 247 GTKYKLKTLETVLYELSVAG 266 Thalassiosira pseudonana CCMP1335
EMG49059     222 SLKYNSQRLNKIVYDLSLRN 241 Candida maltosa Xu316
EGW31868     222 GLKYNSQRLNKIVYDLSLRN 241 Spathaspora passalidarum NRRL Y-27907
XP_003868381 223 SLKYNSQRLNKIVYDLSLRN 242 Candida orthopsilosis Co 90-125
EPY51937     200 SLKYQLKRAEDVVYDMRIHN 219 Schizosaccharomyces cryophilus OY26
EOQ99356     199 ALKYDINKVEGVIYDLTLRN 218 Wallemia ichthyophaga EXF-994
EIM19609     193 SLKYDLNKVEGVIYDLTLRN 212 Wallemia sebi CBS 633.66
Q9P7V3       199 GLKYDLKRSEDVVYDLRIHK 218 Schizosaccharomyces pombe 972h-

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