1BRC,1SHP,1TFX,1PIT,1KUN,1DTK,1BIK,1DTX,1BUN


Conserved Protein Domain Family
KU
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cd00109: KU (this model, PSSM-Id:238057 is obsolete and has been replaced by 438633)
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BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Links
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Statistics
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PSSM-Id: 238057
Aligned: 93 rows
Threshold Bit Score: 48.015
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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trypsin
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:trypsin interaction site
Evidence:
  • Comment:active site inhibitor acts via a substrate-like mechansim
  • Citation:PMID 7683059
  • Structure:1BRC; rat trypsin with APPI inhibitor
  • Comment:most of the contacts are also conserved with inhibitor BPTI
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ### ## #                                     
1BRC_I       3 EVCSEq--aETGPCR-AMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG 56   human
7497155   1148 GRCYLprvdGPLRCD-QLQPRYYYDHSKKHCVAFWWRGCLGNANNFNSFEECSMFCK 1203 Caenorhabditis elegans
7505770    170 AECEHplhfGVQQCTnTSVVRYHFDMESKKCLAFKYTGCGGNENNFKDYSACSNFCI 226  Caenorhabditis elegans
7505769     17 NICDSpvdlGTAKCSnTSSIRYHYDPTVKRCLPFGYTGCGGNENNFADPRICRQRCI 73   Caenorhabditis elegans
4850188     27 GACHDpfflGDTPCDkQWSIRYYMDVPTETCLAFNYTGCGHNWNNFATSQACYEECL 83   Caenorhabditis elegans
7508133    127 NTCSLqydaGKFGSSgKHTPRYFFSKSYKNCMLFTFYGRDGNANNFATYNECKNFCM 183  Caenorhabditis elegans
544480     290 AVCRLp--mAPEPCT-GQPTIWAFDFVTGSCMPYKDGICQANANQFYSRAECQEYCG 343  plaice
7508133     21 TDCFSardtGNSGCGqQGARSFYFHKNTRTCQPFFYQGCDGNSNRFQSKEACESACR 77   Caenorhabditis elegans
7497910    170 HVCSLpvssGSERLAfKHYGRYAYQPGLKNCIRFSYFGQEGNFNNFLTYNDCKKFCM 226  Caenorhabditis elegans
3123221     29 RDCDKp--pDKGNCG-PVRRAFYYDTRLKTCKAFQYRGCNGNGNHFKTETLCRCECL 82   many-banded krait

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