Conserved Protein Domain Family
HECT_2

?
pfam09814: HECT_2 
HECT-like Ubiquitin-conjugating enzyme (E2)-binding
HECT_2 is a family of UbcH10-binding proteins.
Statistics
?
PSSM-Id: 462911
Aligned: 91 rows
Threshold Bit Score: 161.856
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EEH04717             14 ELLPNIRQITLHVSLPASSrlaqssitsdtpgdlvrgnfslsllpsrDAVSLYSSH------------TVHTLPLPA-CV 80 
EFN77356              7 ELRPRLQSCNAFIAMRKDLd--------------------------lKDVQVKLSEsnia-------------------- 40 
XP_001847825         12 ELRPRLQSANFFICFSRRFve-------------------------iKSTKIDLAPdriti------------------- 47 
WGS:AAQB:GK19715-PB   9 ELRPNLRCGNAYLQFNRQLre------------------------dgRKTRIILKEhnvhim-edddeNNLVIRYNCfGM 63 
EDV95222              9 EFRPNLCCGQICLQFDEPIrn-------------------------cKNTRLIINNgdmf-------------------- 43 
XP_002010793          9 ELRPNLSSGHVFLQFDQEIrg-------------------------rKKTRLIIKEhdvhiv------------------ 45 
XP_002054975          9 ELRPNLSSGHVFLQFDQEIrd-------------------------rQKTRLIIKEhdvhiv------------------ 45 
WGS:AAPP:GF19245-PA   9 ELRPNLRSGVVFLQFDHDIgt-------------------------cNQTRLVIREhnvyi--segpvKTSTPRSDS-DS 60 
Q9VWP0                9 ELRPNLRSGVVFLRFDQQVsq-------------------------sQKTRVVVRDynvy-----iseKPKNQAIDL-DS 57  fruit fly
EGD75803              7 EARPSVCSGHLFVRGPSHL-----------------------------NVNVVSQDgrlavvdtqaerQLATIALPP-HV 56 
EEH04717             81 SES-----AHTILSTkltpnp--------pgaghgELLFRLPVDVeaglpgasqpanGQPGHGs--nEVQVPWTAKDMCA 145
EFN77356             41 -----lvlKDHNMDFslpfikivptslsmlsirnnWICFRLQMMPlnsvfgsfsvevLTDSNKsaqlTC-----SQPILE 110
XP_001847825         48 ---stennDEQYEIRlgdffklhtqtlsslliknnYICFRIntnenk-----fhsevLEINEYnactDL-------KLEC 112
WGS:AAQB:GK19715-PB  64 DIQ-----GISIFTVsg-----------------nHLTFRFNYTKidmdal-------------eqntvQVDMQPLVMAC 108
EDV95222             44 ----flenGNSEFVLrhdswdmditqlslfnasgcHITFRFnytki-------dlikLFKIGSgpkvSH---LMPLELSF 109
XP_002010793         46 --engqnsGGSQLVLrhdtfgmdiqrisvfiangcHISFRFnyttl-------dveaLENSIAvpmkAQ-----PLVLGF 111
XP_002054975         46 --engtdsTESELVLrhdsfgmdiqrisvfivngcHISFRFnytti-------dleaLENCVGlpmaPQ-----PLLLSF 111
WGS:AAPP:GF19245-PA  61 EEEyheedEENSLVIrhdcfgmdigcisvfvvtgsHISFRFnysqi-------dldaLDAGSVqv-aME-----PLLLSC 127
Q9VWP0               58 SSEsdsedSDKLMLIrhaqygmdivclstflvsgrNISFRFnynqi-------dlasVDGSAVdv-pLA-----PLLLSC 124 fruit fly
EGD75803             57 RPSglertHQDEHTN--------------------TSTFRLVLHPsdtpfhrkpssvSTSETRss-qQK----------- 104
EEH04717            146 --------E-SRVRCQRCKNTLFTP-SDKGKvtWKDLPSTDWAEMMDLWHCHKPDTHADdhgdaavgtvlhthdenETVK 215
EFN77356            111 dikllfkaSeCIVLCACCKNVISKP-TTFKR--ALPLPDIQCSP--DEWFCCKHSsnd---------------------- 163
XP_001847825        113 rle---kgVnYTVTCSNCGNDLHEQpVAFKR--ILELPSDHMDS--NEWYCHRHDtp------------------eTHTE 167
WGS:AAQB:GK19715-PB 109 re----neE-FSLICHNCGNELAES-TVYKR--LREFPSCIVDP--SDFFCHNHGSAAE--------------------- 157
EDV95222            110 ve----kkDhLTLHCNKCLYELAPG-CNYNR--LRELPSGLFDA--SEFFCHSHGtsgqeq------------------- 161
XP_002010793        112 eeh---seQlVALHCNNCRSELVPG-CSYNR--LRECPSGLIDP--SEFFCHNHGpadk--------------------- 162
XP_002054975        112 ae----rtQtVSLHCSNCHNQLVPG-CSYSR--LREFPSGIIDP--SEFFCHNHGtvtk--------------------- 161
WGS:AAPP:GF19245-PA 128 re-----dDpFALTCRNCSAELVEN-RGYRR--LREFPSCVVDP--GEFFCHNHGsgcds-------------------- 177
Q9VWP0              125 qe-----nEpITINCRDCRAELVAG-RSYRR--LREFPSLLVDP--TEFFCHNHGpagkt-------------------- 174 fruit fly
EGD75803            105 ----------ACVKCTTCKAAVSPP-LQPYR-----LPSLRWHEIQDFVNCCEDDhhth--------------------- 147
EEH04717            216 G--YGAsn--------qVVCTSGTVLIDVLSFVMAEGDCQGlqkskiagnprkgfrasdylvlsptaaqsimmkearkwe 285
EFN77356            164 --------------ivnIETQKSDYLYGSYFALLHKNIFINnl------------------------------------- 192
XP_001847825        168 GecSSKsssaasphpnsFTPAETDLFYGPFYAVLNCQHLQRvh------------------------------------- 210
WGS:AAQB:GK19715-PB 158 ----SHqd--------vLVPPERDLFYGLNFIVVNIFKIKGvm------------------------------------- 188
EDV95222            162 ------------ptssvLVPRATQIYYGLNYIVLNMCVVQNri------------------------------------- 192
XP_002010793        163 -------------paatLVPGPKDLYYGLNYIVLNMSVLQDri------------------------------------- 192
XP_002054975        162 --------------patLVPRRDDLYYGLNHVVLNMTAVEAqv------------------------------------- 190
WGS:AAPP:GF19245-PA 178 -------------kppsLVPAETDLFYGLNYVVVSLSQTNPni------------------------------------- 207
Q9VWP0              175 -------------qpisLVPAETDLFYGLNYVVINFNEESScm------------------------------------- 204 fruit fly
EGD75803            148 -------------vdlsVRIGEHSVLFDDEQLLLQRDQLIThdrq----------------------------------- 179
EEH04717            286 nrgpnqmsgssirseilplsstsrhigngnqpanetKFQPVVDLSCSRCSAVVGEEHK--Afs-----gLRLYKANVSLL 358
EFN77356            193 -------------------------------------riDNKTLTCDKCFLHIGALYScnL--------LKLWNCCVDYK 227
XP_001847825        211 -------------------------------------lrADRFLYCKCCLQFLGVAKRngS--------VKLWYENLKFL 245
WGS:AAQB:GK19715-PB 189 --------------------------------------nrGGQLYCQRCLGLVGNTVL--Ndk-----aAKLWADAVRYL 223
EDV95222            193 -------------------------------------snISGNLYCKRCMRMLGSSIEsgAa-------AKLWADALRWL 228
XP_002010793        193 -------------------------------------mnRADHLYCKRCMWMLGLSTQagAa-------AKLWADALRWL 228
XP_002054975        191 -------------------------------------inRSEHLYCKRCMWMLGLTIEsgSa-------AKLWADALRWL 226
WGS:AAPP:GF19245-PA 208 -------------------------------------liREDHLYCRRCMRFLGLAIFngAa-------ARLWADAVSWL 243
Q9VWP0              205 -------------------------------------lnRDDHLYCQRCMRYLGLTMFdgAa-------ARIWADAVRWR 240 fruit fly
EGD75803            180 --------------------------------pldtSTLSDEVVRCERCLASIGA-----CavfqgqpcVSLHRHAVHMD 222
EEH04717            359 RKPKDGINSdhd---vwETYPVDMIVGTQLLDLVERV-------------GARRFAVHSAEYtdtssrdNKIGLLLWVFN 422
EFN77356            228 PQDDTLS------------IVNATNPLDDFLIFIKDSlt---------niLGEEIILQTSIGk------QTHYLLIKPMD 280
XP_001847825        246 KPDEHEQEHvn-----pASLFRTDDALLNFQYLVRKTvndynfishlglpPIFKIIFEMRRPgq---dgELFYLLMQIMD 317
WGS:AAQB:GK19715-PB 224 PTSLDITQK--------RHLFQHPSVTQVMKRLLHTLwpqsls--plcptKNRALLFTTLPNr------QQQSILIHIVD 287
EDV95222            229 PLSSLNANGndrasaltRLLFKHATVTHLMIRLLSSLwplagt--qfsphGKRAILTTTMPDg------HDHYMLIQVRE 300
XP_002010793        229 PQPTDAT-Apkl---qpRQLFKHSTVTQLMLRLLSTLwptllp-plfspaNSRAVLVASMPDr------QQHHMLIQVLE 297
XP_002054975        227 PSAVKTE-Datq--qepRQLFKYSTVTQLLLRLLNDLwptf------cpgNSRALLVANMPDr------HQHYMLIQVLD 291
WGS:AAPP:GF19245-PA 244 PSGGGST-Sl------pRHFFKSSSLTQLVKRLLHSLwpqplp--qlclsTSRAALVTSMPNr------CHRYMLIHVVE 308
Q9VWP0              241 PAGAATN-Ap------dRHFFQNSTLTQLFKRLLHSLwpqplp--qlclnTSRAVLVTSLPNr------NQQYMFLHVVE 305 fruit fly
EGD75803            223 GGGLPA-------------ISLVHAFIAVVQERMRSY-------------GWSKFLVVVRGEva----tNPSHLLLWIPS 272
EEH04717            423 PDLRYSsllld------------------------------sttdKV------ASITSQRAMKILYQ---EVQDVQSMLN 463
EFN77356            281 RELNLItep----------------------------------yhQIintdapISLQQKCVAKVLYKydtSKIANT---- 322
XP_001847825        318 ANLNVFkirkgvdaedsssasddpseskeaatdeddddddvftpsPKrpikrnIHVDRHRTMKVMYRydqFDQQPIFNFW 397
WGS:AAQB:GK19715-PB 288 SQLRVLrri----------------------------------qpNN------PDLQCFFACKMYFGinrHDQQIPESVP 327
EDV95222            301 TQLAILrri----------------------------------pnDEy----lDKGCFHRACKLYFRdygSCHFD--RQW 340
XP_002010793        298 PQLTVLrrt----------------------------------vsET------EQLQHYRACKLYFRvfgSCPPD--APV 335
XP_002054975        292 PQLSVLrrt----------------------------------gsETpkctdpQQLQHSRACKLYFRvfgSCQQD--PTT 335
WGS:AAPP:GF19245-PA 309 SQLRVLrrv----------------------------------qpHS------NKLRCYRACKLYFGlfgSSSSQEQPEL 348
Q9VWP0              306 SQLRVLrri----------------------------------rpNS------NRLRCFRACKLYYGvfgAN-----PPL 340 fruit fly
EGD75803            273 PHVLDVvtcll-----------------------------plqneRN------HTQETFSALKVLFKhsfASHSPTSSSD 317
EEH04717            464 paq----gvPSPAALEEVSLPPNIYDGVKQTLERTSEALPISARLVLrPGPI 511
EFN77356            323 ---------NNHWNVEYHEVSLPMIEAGLKHLLSSTERLPHNNRNIA-DYFL 364
XP_001847825        398 ---------LQDSNVVSVEISEQMFRAAVRYLDDNSDYVPECYRNNL-GFSL 439
WGS:AAQB:GK19715-PB 328 kp------wQSDHSLPQMEISPRMFQELHTQLTTNSQLVPYAWRFNTaEEKL 373
EDV95222            341 leqwmqqqeQQQQYVPKLSISPYLYAELLKRFDDNMSLIPKRLRYNNfEEKL 392
XP_002010793        336 lt-----qwQQQIEVPKMHISPHMFLELQARFDYNSALIPHAWRYNSeEEKL 382
XP_002054975        336 li-----qwQEQMQVPKMTISPYMFLELQARLNCNSMLIPHAWRYNTaEEKL 382
WGS:AAPP:GF19245-PA 349 mq-----qwQTEQTLPQMEISPDMFQALQERLEANSQLIPLAWRFNApDQQL 395
Q9VWP0              341 le-----kwQAQQTLPQMDVSPNMFLKIQKRLETNGHLIPDALSTNCaEEHL 387 fruit fly
EGD75803            318 vva----awHRDATVAELETTMETLLAVVRVLESTHRLHPPAHRVMA-SFPA 364
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap