3LK7


Conserved Protein Domain Family
MurD

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COG0771: MurD 
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]
UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Statistics
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PSSM-Id: 440534
Aligned: 870 rows
Threshold Bit Score: 272.724
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LK7_A         6 TFENKKVLVLGLARSGEAAARLLAKLGAIVTVNDGKPFDENPtAq--SLLE--EG---IkvvcgsHplELLD---E-DFC 74 
WP_069178979  11 HWDEKNVVIVGAGRQGQAAARFLISRHVNVTVTDRAPGEKCA-AaieALSG--LP---IrwvtggHplSLLD---EaDFV 81 
WP_095042317   6 ALHGKRLVILGMARQGTALARFAVGVGAFVTLSDMRPAVKLA-GarqALAD--LPadrLrfvlgeHplSLLD---AcDVL 79 
WP_011165559   7 DLKDKRILVVGLGKTGVSLAHFLTKHGAQVTVTDHKSKPELS-VqleQLGE--LP---IkfelggHspKTFI---AqDLV 77 
WP_102241878   5 RFKGKKVLIVGIGKTGFSLINFFNKLECEIRVTDIKPIFDLN-KsvkKLKKiePP---LemtfgeHkdEDFL---EaDVI 77 
WP_083857727  38 MFRGQKVVILGLARQGSALARFFVAAGARVTVSDAAPAERLA-TelaRLRD--LP---VelalggHplELLD---RcDLL 108
WP_087862626   3 QWDGMQVVMIGAARQGIALSRYLAKKGARVILNDQRSAEALK-NvreSLPS--EN---ItwvtggHplEILT---GaDLV 73 
AEJ41582       1 --mTQHIAVVGLGINNRPLVPFWLERHATVAVFDRRPESEIW-EdlaEFRHh-PG---LtvvggpDylRRLAewpHlGHV 73 
WP_116224459   3 NWQGKQVLVIGAARQGLAASRFLAGHGAKVLLNDSRPQESFS-AiipDLEK--QG---IsyhfgsHplELLQ---GtDLV 73 
WP_013560728   4 NWKDSRVLILGAARQGQALARFLCQRGAAVTLNDQNPAEKLT-LameVLAE--YP---IewvtggHplELLE---RhDLL 74 
3LK7_A        75 yxIKNPGIPYNNPXVKKALEKQIPVLTEVELAY----LVSESQLIGITGSNGKTTTTTXIAEVLNAG------GQR-GLL 143
WP_069178979  82 --CVSGGADLRQPFLAEAVNRGIPLLNDTEIFF----QESPAPIIGLTGSAGKTTTTTLVGRIAESDrqrrhsRTS-VFV 154
WP_095042317  80 --ALSGGVPSDSPLVAEARRRGIPLTNDSLEFM----RRAPAPVMGITGSAGKTTTTALVGQMGQKS------ARQ-TWI 146
WP_011165559  78 --ILSPGVPSNLKIFDYARSQGIKITGEFEFSA----GFIKEPIIGLTGTNGKTTVAKITEAILTES------GVK-TWV 144
WP_102241878  78 --VYSAAVNPNLPQLELARKNGKEVYSDFALAY----KLCKKPVIAVCGSFGRTTIAAMIGFTLKVD------GKN-VFV 144
WP_083857727 109 --CLSGGVPAQLPIVQEAIRRKIPLSNDSLLTLqlarQRGLGPIAAITGSSGKTTTTTLVGEMLAAG------GRR-VHV 179
WP_087862626  74 --CVSGGVPLNLPIVLEAARRKIPISNDSQIFL----EETPCPVIGITGSSGKTTTTALVGLIAEKHfslkkpGRK-AWM 146
AEJ41582      74 --YLTPGMPKTGPEIQQVTARGGHLTCETELFF----ETCPAPIIGITGSQGKTTTTTLVGEALKRD------GSRpVWV 141
WP_116224459  74 --CISGGVPLEIPLIQEALRRNIELSNDSQIFM----QAVKANVIGITGSAGKTTTTTLCGEIAKAElt---sPRN-AWV 143
WP_013560728  75 --CLSGGVPETLPIVQEALRRGMPITNDSQIFM----EEVPCRVIGITGSAGKTTTTTLVGRMASRAvv---aPQK-AWV 144
3LK7_A       144 AGNIGFPASEV--VQAANdKDTLVXELSSFQLXGV----------KEFRPHIAVITNLXPTHLDYH-GSFEDYVAAKWNI 210
WP_069178979 155 GGNIGTPLIAR--IDEIGaNDCVILELSSFQLELV----------T-ISPHIAAVLNITPNHLDRH-GTMEEYIRAKRNI 220
WP_095042317 147 GGNIGRPPLED--LAHMSsNDLIVVELSSFQLELW----------DECSPPIAAVLNLTPNHLDRH-RTMAAYAEAKSHI 213
WP_011165559 145 GGANEKPLVDY--LRLDDkAQVVIAEVSSFMLEHC----------DTFNPGNIVFTNLAENHLDRY-RSMEEYVNAKRRI 211
WP_102241878 145 GGTSEMPFIEYclLPNMNeIDYVVVEVSAIQMKSL----------QDFHPKLVVFPNIGENFSKANfASVSEYIETKLSI 214
WP_083857727 180 GGNIGTPLIDR--LDSIApGDCIVLELSSFQLELFdprwawgrvqDI-GPDVAAILNITPNHLDRH-PDMAAYAGAKFNL 255
WP_087862626 147 GGNIGNPLIQY--LDQMHpEDLAVMELSSFQLEIM----------TR-SPQIAAILNLTPNHLDRH-ETMAEYISAKSHI 212
AEJ41582     142 GGNIGRSLLPE--LPRIKaSDWVVMELSSFQLELV----------NR-SPQGAAWLNLSPNHLDIH-GSFEAYRQAKQHI 207
WP_116224459 144 GGNIGFPLIEN--LENIQaEDWAVVEFSSFQLELM----------N-VSPHIAVVLNITPNHLDRH-KTMEAYTAAKAHI 209
WP_013560728 145 GGNIGVPLIDR--LDEIQpADVVVLELSSFQLQWI----------TR-SPQVAAVLNITPNHLDRH-GTMEAYTAAKARI 210
3LK7_A       211 QNQXSssdFLVLNFNQGISKEL---------------AKT--T-KATIVPF----------STTEKV--------D---- 250
WP_069178979 221 LNFQSesdWAVLSRDDGNSAAL---------------RTA--V-RGKSATF----------GFEPPF--------Gde-- 262
WP_095042317 214 LRHQKpgdVAVLPADDPGALEM---------------RGL--A-RGRLRLF----------SAHEPV--------Sd--- 254
WP_011165559 212 FKNTNqatTSILNADDNAVVEL---------------ARDpaVqRGRIFYF----------SRKPAL--------Epqim 258
WP_102241878 215 IKKLSpedTLVANYDSLANNAF---------------FRN--A-NCQLYWY----------SRRSyV--------Tlgvm 258
WP_083857727 256 LHCLPeeaAIVLSAEDAITRRVasstwrandpslpasWAA--V-AGELETVleevgalvagRRTPPLlfhrysrvVn--- 329
WP_087862626 213 LTHQTaqdIAVLNRDDPHTRRL---------------YSE--V-RGRLITF----------GFHPPHd------nQd--- 255
AEJ41582     208 IEYQTpdhWAVLPADDPAILPS---------------LRH--Y-RGQPVYF----------SLDRAL--------Ph--- 248
WP_116224459 210 LQHQNvddIAILNRDDPGSLGL---------------TGE--V-RGNLLTF----------GFNPPLy-------Gn--- 251
WP_013560728 211 LEFQSatdIAVLGREDAGAWGL---------------REK--V-RGDLISF----------GLNHPA--------Eg--- 251
3LK7_A       251 ----G-AYVQDKQLFYK-----GENIXSVDDIGVPGSHNVENALATIAVAKLAGISNQVIRETLSNFGGVKHRLQSLGKV 320
WP_069178979 263 --aiA-VGIDEGFVFATin-gkRKNLLKRIEISLPGRHNLSNVMAAAAIALSAGFDPLSIQGGIRGFSGVPHRLETVGKL 338
WP_095042317 255 ----G-AFVQDGQIWLSda-rgQTALCPVAASRLRGRHNVLNVLAAVTLADAAGVPHEAIVEGIRLFDGVPHRLETVRRV 328
WP_011165559 259 -nigGaVNI-GDEIRVRtg--pEIESFNIKGMKMRGKHSVENIMAAILASREHGATREAVQKVINTFTGLPHRIEYVRKV 334
WP_102241878 259 neiqG-THFhDRRIHsni---nyHSEFKVSKMRIVGQNNRENLMAAVTACKALDVSDDAIQTCIEKFPGIPNRMEFIMEK 334
WP_083857727 330 ----G-AWGEGDRLFYQg-----qEICLRKEIKLRGEHNVGNLLAAAAIGGALGAPVEAMRHVARTFRGVPHRLEVVAEV 399
WP_087862626 256 ----S-TYLKRGKLYLQas-gqVAKIVEVDRVNLRGSHNLANVLAAIAISAAAAFSLQAIYAGIVEFTGVPHRLEYVRDW 329
AEJ41582     249 ----G-SYLQDGQLWWAapdrpPYPVMAASAVRLLGRHNLANALAAIAIVAQAGGSLEALREVLSTFQGVPHRLEQVREV 323
WP_116224459 252 ----G-CFVQDDHIVVTwq-dnLTPLVPLDSLHLTGRHNLANALAACAASFAAGFSPKAMRDGIDAVKGVPHRLELVRER 325
WP_013560728 252 ---kG-TFYDNGWLWYQge-mvEEALFERGKIALRGTHNLLNVLAACAIGIAAGFPPEALLDGVQGFGGVPHRLELVREW 326
3LK7_A       321 HGISFYNDSKSTNILATQKALSGFDNt--KVILIAGGLDRGN-EFDELIPDITG--LKHXVVLGESASRVKRAAQKAG-- 393
WP_069178979 339 HGVRYINDSIATAPERTLAALNAFSD---PMILLLGGRDKKL-PWGKLADELNRk-AKAAVCFGEAGPMIAQALESSPvr 413
WP_095042317 329 GGVQYVNDSIATAPERALAALAAFEE---PIILLAGGRDKDM-VWDGWARQVAQr-VKHVVLFGELGPALGQRLGDRA-- 401
WP_011165559 335 GGVMFYNDSKATNVHAVLRALDTFDE---NVILIAGGKDTNL-NYEPLRTSVKRk-VKTLILVGEAKERINRDLGDF--- 406
WP_102241878 335 NGVSFYNDSKAETMPEMLASLKSFKE---PVILIAGGKDNEDlNFDPFAKDMIGn-ARVLVLVGECKERLNRALGDHN-- 408
WP_083857727 400 NGVTWVNDSIATSPERAVAGLRSFDTsdgALILLAGGKDKKL-PWDEFADEALAr-VDMLIGFGEAGEMIVRTVQERAif 477
WP_087862626 330 NGAAWYNDSIATSPERAIAALQSFDE---PIILLAGGRDKNL-PWKDLAEWIYKk-VDHLVLFGEAATLIKDAVNETTpg 404
AEJ41582     324 DGVLYINDSIATTPDRTVAALNALER---PIVLIAGGYDKHL-EYDTLGQAVVQrhVRFVVALGQVRYKIQDAVRQFg-- 397
WP_116224459 326 AGVRWYNDSIATAPERVMAAVRAMNA---PLVLLLGGRDKDL-PWGELAELLAKr-KPKVILFGEAGDLIKNALMQNGa- 399
WP_013560728 327 RGVRWYNDSIATAPERTIAAIRSFEE---PLVLMLGGRDKKL-PWDSLADLIHEr-VDHVVVFGEAAEKIAHAIGEVRpg 401
3LK7_A       394 -----VTYSDALDVRDAVHKAYEVAQQGDVILLSPANASWDXYKNFEVRGDEFIDTFES-LR 449
WP_069178979 414 n--prFVVRRAATMLDALEIARELGEAGDLVLLSPGGTSYDAYKDFEERGNEFRSWVRSqIs 473
WP_095042317 402 ------PTTTVETLAEAVSVAHEQAGTGDVVLLSPGGTSFDGYSDFVERGEHFRLLVRE-LD 456
WP_011165559 407 -----SETFLIGTFEEAVLIAYQKSRIGDVVLLSPGCSSFDMFDSFEERGDYFKEIVRK-FH 462
WP_102241878 409 ------QTYIVGSFEESVLFAYQKSRTGDVILLSPGNPASDFFRDYEERGNYFKKLVYQ-L- 462
WP_083857727 478 rqrraPSTAVVHRLEEAVELAARVAEPGAVVLLSPGGTSYDAYRDFEARGEHFRQLVKE-IA 538
WP_087862626 405 t--qpFTVDLCQGLKDAVIKASEYASPGDVVLLSPGGTSYDEFVDFEERGKRFIQWVKE-LS 463
AEJ41582     398 ----eVPVVLADTFEQAFHTAVQASRPGDIVLLSPAAASYDMFRNFEARGQRFRELVQA-LP 454
WP_116224459 400 ----dYAIIQVDDLQSAVQEADRLAMPGECVLLSPGGTSFDAFRDFEERGECFRKIVKE-Lp 456
WP_013560728 402 k--rpFTLTLCKTVQEAVQAAAAVAEEGDVVLFSPGGTSYDEFRDFEERGERFRKWVQE-LL 460
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