?cl28904: PTP_DSP_cys Superfamily (this model, PSSM-Id:421693 is obsolete and has been replaced by 475123)
cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily This superfamily is composed of cys-based phosphatases, which includes classical protein tyrosine phosphatases (PTPs) as well as dual-specificity phosphatases (DUSPs or DSPs). They are characterized by a CxxxxxR conserved catalytic loop (where C is the catalytic cysteine, x is any amino acid, and R is an arginine). PTPs are part of the tyrosine phosphorylation/dephosphorylation regulatory mechanism, and are important in the response of the cells to physiologic and pathologic changes in their environment. DUSPs show more substrate diversity (including RNA and lipids) and include pTyr, pSer, and pThr phosphatases.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",