1XUU


Conserved Protein Domain Family
NeuB_NnaB
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TIGR03569: NeuB_NnaB 
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N-acetylneuraminate synthase
This family is a subset of the pfam03102 and is believed to include only authentic NeuB N-acetylneuraminate (sialic acid) synthase enzymes. The majority of the genes identified by this model are observed adjacent to both the NeuA and NeuC genes which together effect the biosynthesis of CMP-N-acetylneuraminate from UDP-N-acetylglucosamine.
Links
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Statistics
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PSSM-Id: 274655
Aligned: 36 rows
Threshold Bit Score: 468.6
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XUU_A        20 PLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSDEAKq----vIPGN-ADVSIYEIMERCALNEEDEI 94  Neisseria menin...
WP_011499634  13 VFIIAEAGVNHNGSIALAKQLIDVAAKSNADAVKFQTFVTEDVVSINTPkaeyqkHTTE-SSESQFEMIKKLELSKTDHK 91  Methanococcoide...
WP_011868275  15 AFIIAEAGVNHNGSLELAKKLIDVAFEAGVDAVKFQTFKTENVVTENAEkaeyqiQNTGvESESQYEMIKKLELSEKDFE 94  Methanococcus m...
WP_010946489  19 CFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEkaeyqkNNAP-ESSTQYEMLKALELSEEDHY 97  Legionella pneu...
WP_011382527  18 CFVIAEAGVNHNGDLALAHRLVDMAVQAGADAVKFQTFTAEKVVSAQAPkaayqkVTTG-GGQSQLDMVRGFQLPPEAFA 96  Magnetospirillu...
WP_002258013  20 PLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSDEAKq----vIPGN-ADVSIYEIMERCALNEEDEI 94  Neisseria menin...
WP_012022411  19 PLVIAEIGINHEGLLIAAKEMVDAAYRAGVEVVKHQTHIVEDEMTGAAKk----vIPGN-ADVSIYEIMERCSLNEADEL 93  Flavobacterium ...
WP_011233779  24 PVVVAEIGINHEGSLETAYEMVDAAVSAGAEIIKHQTHVVEDEMSADAKk----vIPGN-ADVSIYEIMERCALNEEDET 98  Idiomarina loih...
WP_011541869  11 TFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAkaayqqRQTG-AG-TQYEMIRALELDDAAHE 88  Sphingopyxis al...
WP_011578114  16 PLVVAEIGINHNGSLEIAKLMVDAAKRVGIEVIKHQTHIIEDEMSISALk----vIPGN-SELSIYEIMKKCALSKNDER 90  Helicobacter ac...

1XUU_A        95 KLKEYVESKGMIFISTPFSRAAALRLQRMDIPAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAG 174 Neisseria menin...
WP_011499634  92 ELMKHAEQKNIMFLSTPFDERSVDLLVELGVPLIKISSGEITNHPLLKYISRKGIPIILSTGMSTLEEVAEAVSVIKDAG 171 Methanococcoide...
WP_011868275  95 RLYNYCQEKGILFLSTPFDFESADFLDDL-VPLFKISSTDLNNIPFLKHIAKKKKPVIISTGMGTLCEIEEAVTALKNAG 173 Methanococcus m...
WP_010946489  98 LLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQEVRVAIDTVKPYY 177 Legionella pneu...
WP_011382527  97 ELSEHCIQAGILFMSTPFDLDSVDVLDRLDVPAFKLPSGEITNPLLLRRVAATGRPVILSTGMGSLVEVAAAVDILERAG 176 Magnetospirillu...
WP_002258013  95 KLKEYVESKGMIFISTPFSRAAALRLQRMDIPAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAG 174 Neisseria menin...
WP_012022411  94 ELKKYVESKGMIFISTPFSRAAAERLKKFDIPAYKIGSGECNNYPLLEHIASFGKPVILSTGMNTIESITKAVAVFDKHN 173 Flavobacterium ...
WP_011233779  99 KLKEYVESKGAIFISTPFSRAAAERLERMGVEAYKIGSGECNNYPLLELVASYKKPIILSTGMNDIPSIAKAVDIFRKHG 178 Idiomarina loih...
WP_011541869  89 RLARHCAERGIEFMSTPFAPWAVDMLLGLGMRRIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRAVDWIRTAQ 168 Sphingopyxis al...
WP_011578114  91 ELKEYTEKQGLIFLSTPFSRAAANFLEDLGVVGYKIGSGEMNNTPLLKHIANFKKPMIISTGMHDLESVKECINPIIDKV 170 Helicobacter ac...

1XUU_A       175 VP---------YALLHCTNIYPTPYEDVRLGGMNDLSEAFpDAII-GLSDHTLDNYACLGAVALGGSILERHFTDRMDRP 244 Neisseria menin...
WP_011499634 172 CEd--------LTLLHCTSSYPARVEDCNLLTMETMADVF-DVQV-GYSDHTSGICVPLAAAAMGACVIEKHFTLDKNLT 241 Methanococcoide...
WP_011868275 174 NHe--------IMLLHCVTSYPAKDESLNLNVIHTLRNAF-KLDV-GFSDHSLGIYASIAAVSMGATIIEKHFTLDNELP 243 Methanococcus m...
WP_010946489 178 GNsls----dyLVLLHCTSNYPASYQDVNLKAMQTLADEF-QLPV-GYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLP 251 Legionella pneu...
WP_011382527 177 CHd--------LMLLHCTSAYPAPVESANLRAMSTLAAAF-HRPV-GYSDHTEGFEAAIAAVALGACCIEKHFTLDRSLP 246 Magnetospirillu...
WP_002258013 175 VP---------YALLHCTNIYPTPYEDVRLGGMNDLSEAFpDAII-GLSDHTLDNYACLGAVALGGSILERHFTDRMDRP 244 Neisseria menin...
WP_012022411 174 IP---------VALLHTTNLYPTPIHLVRFGAMLELHQAF-PDKVfGLSDHTLNNNACLGAVALGASILERHFTDHMQRT 243 Flavobacterium ...
WP_011233779 179 VQ---------YALLHCTNVYPTPDNLIRLGAMNQLQDAFdDAVV-GLSDHSIDNLACLGAVAVGASILERHFTDHKQRT 248 Idiomarina loih...
WP_011541869 169 SAagiamspgdLVVLHCTSEYPAPAASVNLRAMDTLAAAL-DVPV-GYSDHSLGIEIAVAAVARGAAVIEKHFTENSRDH 246 Sphingopyxis al...
WP_011578114 171 P----------IALLHTTNLYPTPFELVRLNAMLDLKNAF-KVPV-GLSDHTLNNNACKSAIALGASIVERHFTDTKDRE 238 Helicobacter ac...

1XUU_A       245 GPDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELLSGDNLWVKRPGN-GdFSVN 323 Neisseria menin...
WP_011499634 242 GPDHMASLEPTELEEMVRGIRLVEKARGSSVKAPVESELEVRDIVRRSIVAKVNIPAGTVIAEDLLAFKRPGV-G-MPPK 319 Methanococcoide...
WP_011868275 244 GPDHKASLNPTQLKELVIGIRSVEKAFGDGIKRLTEEEIEIKKVARRSIVTKKDIAENSIITEDMIILKRPGT-G-IKPK 321 Methanococcus m...
WP_010946489 252 GPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILLRPGT-G-IAPS 329 Legionella pneu...
WP_011382527 247 GPDHLASVSPADLGALVAVIRRVEKGLGDGCKRPTVAEEDTRAVARRSLFAARALAAGAVMTEEDLIALRPGG-G-ISPM 324 Magnetospirillu...
WP_002258013 245 GPDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELLSGDNLWVKRPGN-GdFSVN 323 Neisseria menin...
WP_012022411 244 GPDIVCSMDEKACQELIISSAEIAQMRG-GSKKPANEEQVTIDFAFATVCSIAPIKKGEVFSKENIWVKRPGT-GkILAE 321 Flavobacterium ...
WP_011233779 249 GPDINCSMDTEECRSLIQESKRMKAMRG-GQKGAVAEEQVTIDFAYASVVTIKPIKKGETFSQDNLWVKRPGT-GqFLAD 326 Idiomarina loih...
WP_011541869 247 GPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTDINRGDRLDATTIAFLRPGD-G-IGPE 324 Sphingopyxis al...
WP_011578114 239 GPDIVCSMDEEEAKDLVKSAQEIFLMRG-GSKTKIKEEQVTRDFAFATMVAIKRIKKGEKITESNAWVKRPGVkG-ILAK 316 Helicobacter ac...

1XUU_A       324 EYETLFGKVAACNIRKGAQI 343 Neisseria meningitidis M01-240355
WP_011499634 320 YLDRLIGKVPISEIKKDSLI 339 Methanococcoides burtonii
WP_011868275 322 YLQDIIGkkvkkdvkkdsvl 341 Methanococcus maripaludis
WP_010946489 330 EISNIVGSRLSMNLSAGTTL 349 Legionella pneumophila
WP_011382527 325 QVDMVVGRRLTRAVAEGTLL 344 Magnetospirillum magneticum
WP_002258013 324 EYETLFGKVAACNIRKGAQI 343 Neisseria meningitidis
WP_012022411 322 HFNDLIGKTAARDIDNDEQL 341 Flavobacterium johnsoniae
WP_011233779 327 DYENLMGKTAAQDIENDVQL 346 Idiomarina loihiensis
WP_011541869 325 RADWLFARTAARDIARGSKL 344 Sphingopyxis alaskensis
WP_011578114 317 DYEKTLGRVAKIDIGIDEHI 336 Helicobacter acinonychis
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