Conserved Protein Domain Family
NCS2

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COG2252: NCS2 
Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family [Nucleotide transport and metabolism]
Statistics
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PSSM-Id: 441853
Aligned: 616 rows
Threshold Bit Score: 313.131
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015772262   3 Mantssqtt--------------------qkppasgfSG----FLDRTYHISERGSTLGREIRGGLVTFFAMSYIIILNP 58 
WP_013346235   1 Maitsil-------------------------nragsST----LLDSTFKLSQRNTTVGTELYAGFVTFLAMSYILAVNP 51 
WP_003774898   1 M------------------------------------KN----ILNKYFGIEEAGSTIKREFAGGLTAFLSMSYVIFVNP 40 
WP_015492263   1 Mas---------------------------------aRG----ALDRYFGITERGSTLSAEIKGGLITFLSMSYILAVNP 43 
WP_016339217   1 Mf----------------------------------iTK----QVKKFFKFDELKTTFKKEIIGGLTTFLAMIYILSVQP 42 
WP_081695863   1 MdnkslkqtqveneselfinetpeqtaqrnkeafvfsNNkairSIEKYFKFDTLGAIMKKEIIGGITTFLSLMYILTVNP 80 
WP_045109494   1 --------------------------------------------MDKYFLLSARGATVKNEIYAGLITFLAMSYILAVNP 36 
WP_025734736   1 Mnknktfkad------------------kslkqnylqNN----KIAKYFKFSDFNTSFKKEIIGGISTFLSMIYILSVEP 58 
WP_025734791   1 Mqknnvlnd---------------------kdqfqwsQNktvyRIQKYFQFDKFNTTLKKELLGGLTTFLALVYILSVNK 59 
WP_106720223   1 M-------------------------------------E----KIKKFFKVEQRGSTLTKEILAGVTIFLAMAYILPVNS 39 
WP_015772262  59 LILGL-Tpd--stGa---fLgaelatgdptaagaGIPLIAAATALIAGVLSITMGAVANFPIALAAGLGLNALVAYTIV- 131
WP_013346235  52 AILGSiE------G-----M--------------DKGAVFTATALASAFATLIMGLFGNYPVMLAPGMSMNGFFKGMLL- 105
WP_003774898  41 IILGQ-A------G-----M--------------PKDAVFIATIISSAIAMLIMGLYAKFPLGLAPCMSMNAFFAFSVV- 93 
WP_015492263  44 LILSP-Aa----eG-----Y--------------TFDELFTATALAACIACLLMGLYARFPVALAPGMGLNAFLSYTIC- 98 
WP_016339217  43 SMLSV-AndinfpGdpshnM--------------AFGGIFIATAIAAFLSTLIMGLSANMPVGLAPGMGLNAIFTFNVA- 106
WP_081695863  81 GLVSG-Tpsi-ntGag--nM--------------NYFGIFFATALVSGICCIIMGLFANIPVAMSTSMGMNALVSVNIG- 141
WP_045109494  37 AILGSiE------G-----I--------------DKGSIFTATALSAAIATFIMGAFSKYPIMLAPGMSMNGFFKAILLg 91 
WP_025734736  59 NLLGK-Aqs---vAdpnqfM--------------NAGGVFVATALTSFVATFIMGVCANVPIALAPSMGLNAMFSFNIA- 119
WP_025734791  60 GILEL-Spsind---seqhM--------------NGFGIFFATAITSIVATLLMGLWANVPIVMSPGMGMNTLFTYTLA- 120
WP_106720223  40 FMLEA-A------G-----L--------------PIGGVFFATAVSAAIATLIMGIFANLPVALAPGMGLNAFFTYTLVn 93 
WP_015772262 132 KM-PGMTWVDGMGLVVLEGIVILVLVLTGFRTAVFRAVPAGLKTAISVGIGLFIAFIGLVNAGVVTTpamfdyvpGnqPG 210
WP_013346235 106 SGsVALIWHEALFGIFLSGIVYLIFSMTRIRKQMIESIPEDLKLAITVSLGLFIAFLGLKNAGIIVA--------N--PV 175
WP_003774898  94 MQ-MGISWQTALASVLASSILFIILAASGVRSKIIKSIPLTIKQAGTVGLGIFIAFVSFKNSGIIVP--------D--PG 162
WP_015492263  99 QS-MGFTYEQGLMVVFISGTMFFLVTVSGIRRGMVESIPKSLKIAIAAGIGFFIAIIDLYNTGIIVH--------G--TS 167
WP_016339217 107 -N-NGVGYQGALISVMISSILFCIISATKVRIIIINSIPKSLKLAIGAGIGFFIAYLGLHNIGLVGD--------T--AV 174
WP_081695863 142 IS-GGLGFEGAMIVTMLSSVVFVTVSLTPLRSFIIKSIPKGIVLAIGIGIGLFIAYVGISSMGWLAQ--------E--NG 210
WP_045109494  92 GG-ISLLWHEALFAIFLSGCLYLILSLTPARKVMIDAIPEDLKLGIAVGLGLFVSFLGLRNAGIIVS--------N--PF 160
WP_025734736 120 NQ-GGIGYEGALIATTISSIIFCIMSVTKLRVMLIKSLPHSIHLAIGVGIGFFIAYVGIVNMGWVEK--------S--AS 188
WP_025734791 121 QQ-AKLGFEGAMIAVLLASIFFFLVTVTPMRQMILQGIPKSLSVIFAVAIAFFIAYVGLEQMGWFAI--------E--KT 189
WP_106720223  94 FG-LGYTPKAALAAVLVSGILFLIISLTGLRKVIINAIPKGLKLSVGAGIGFFIAFIGLKNAGIIVG--------D--GA 162
WP_015772262 211 T----------PV-QLgtsKSI--DSLPMLVFFLGLLAIIILTARKVRGAMLWSILGATVLAVVLeqtleigaknqgtga 277
WP_013346235 176 V----------LV-GL---GDI--SSPQVAIAFISLFVALGCMVRDVKLATFIAFVTSIVLTLLCda------------- 226
WP_003774898 163 M----------FI-TF---GGF--DNPNVIIAFVGIITAAFFLVRGNQYAVFLGMVGAALCGLLMrlg------------ 214
WP_015492263 168 S----------AL-VP---GDM--SDPGVLLALFCIIVTVCLWYRRKWYAIILGIIATWAIGALLfr------------- 218
WP_016339217 175 TpggsivngglPIaAL---GDLktNWPIILLGLGVLILILILHFKKVPGAIAIAIFAGLAVSILV--------------- 236
WP_081695863 211 I----------PMaSV---ATLkdNYLPIILGSITLLLILFLAFKKIPGAVAIAILSMSVIAIIL--------------- 262
WP_045109494 161 T----------LV-SM---GDV--NDPKVFIALFSIFIAIGCLVRDMKLATVISFISSIILSLLSdh------------- 211
WP_025734736 189 g---------lPVaNL---SNFklNYPGIILGTVVLFGAIILFYKKFFAPIIVMLIGGFIIAIIL--------------- 241
WP_025734791 190 Sg--------lPVaSL---STLkeNYLFIILGMITLCLMLFFHYKKINGGVALSILIGFVLAIIL--------------- 243
WP_106720223 163 T----------FV-TL---GNL--AHPTVLLGLFGLILVVVLYALKFRFALITAIVSTAVVGLIL--------------- 211
WP_015772262 278 gdnpaGwnlnAPA----L-PD-S--W---V-Q-IP---------D-F--------SL-L---------GQ-F-----SL- 309
WP_013346235 227 ---vlGt--qFAP----L-PE-Q--W---V-S-APp--------S-Le-------PS-F---------GQ-If----NF- 256
WP_003774898 215 --vnmG----VLS----MtPD----V---V-AtLP---------Q-Lpa----gsPIvFpiepiqtmvNEtMfvavkEL- 261
WP_015492263 219 ----yG----LESeigtL-PD-AglVt-gI-S-AP---------D-F--------GL-F---------AK-Vft-gfEMf 255
WP_016339217 237 -----Gn----LG----T-SDf---IkqnF-Shwtg-----wsyDdFs---------gFt--------GN-Ik---sTF- 271
WP_081695863 263 -----As----T-----L-PSdSkaIs-lLgS-ADlrkwegwnyD-Fd---------gFa--------WN-Wt---sTF- 302
WP_045109494 212 ---flGs--nLIT----L-PT-D--V---F-S-MPp--------S-La-------PT-F---------GA-If----DL- 241
WP_025734736 242 -----An----VTd-----NE-A--IqhsF-G-AAkwkagqwnyDeFk---------gFf--------SN-Le---nTY- 280
WP_025734791 244 -----An----T-----L-PSeQ--It-kIsS-ANfrngfdftyD-Fd---------gFi--------WN-Ie---sGM- 281
WP_106720223 212 -----G----FLG------------Vd--M---MPayd----aqG-MsgvwtgasET-V---------FAaFg----GF- 245
WP_015772262 310 FGSF-Gki--giVAVVLLVFSLLLADFFDTMGTMVAVGGEAGLLDKEG-NPPNIQRILVVDSLGAIAGGAGSVSSNTAFI 385
WP_013346235 257 -EFL-Tad--klFDLLFIVLVFFIVDFFDGLSTIVGVGRDAGIINKDG-KVPNARSALVADASGTIAGSVLGTTSITSFS 331
WP_003774898 262 PNLL-N------PQAIIVVLTFLFLDFFGTATTLSAAASQIPHIPQE--EFENNNRIYMADALGTFVGSLFGTSNLSTYI 332
WP_015492263 256 PSSM-W------VAFIGALVSMFIVDMFDTTGTLISVSSMSGMSEGRD-EFDTIDVAMRADAAASLSGAMVGTSTTTSYI 327
WP_016339217 272 AEFT-NreiwtsPIMYISIFVFLFVCFFDATGTLYSISEQISEQT--GnKYQLNSRALLADSTGTLIGGVLGCSPVTTFV 348
WP_081695863 303 -KAFgNakiwtsPVTYISIFVVMLINFFDATGTMAAFTHQLDQKTNQ--HKEISQKALVIDSMGTMMASVTGTTPLGVFA 379
WP_045109494 242 -SQL-Tmp--kmTDFIFLVIIFFIVDFFDGLSTIVGVGRDAGIIGKDG-KVPNAKSALVADSGGTIIGTILGTTSITAYS 316
WP_025734736 281 KQFL-NpviwakPTMYISIFIFIILNFFDATGTLTSVNIEMNRAS--GlNQQLSHKALVIDAGATVLGSGLGVSHMACYT 357
WP_025734791 282 KAFA-NpkiwsnPGLYVCVLVVMLMSFFDDSAALSALYMQRNQHi-KT-PMEVSRPTMLIDAGSGILNGLVGVSSMSIMV 358
WP_106720223 246 KELF-Ss-----WQALAVIFSLLFVDFFDTAGTLMAVGNQAGLINEEG-VIEGGDNALIADSIGTIAGAMLGTSNVTSYI 318
WP_015772262 386 ESASGVGEGARTGLAPIVTGLAFLLSTLFAPVVQLVP---------------YEAATPALVFVGFLMMTQVTGIKW-SDY 449
WP_013346235 332 ESGIASAQGAKTGLAAVMVAVLFLLSLFLYPVFSLFS---------------TAIVAPAMIVVGIYMVGRLGQIQW-EHK 395
WP_003774898 333 ESVSGIINGGRTGLMAVVTAVLFLLSMFFYPLLSLVT---------------PAVTTPAMVVIGIFMMQNITNIEWhSGF 397
WP_015492263 328 ESFTGIESGARTGILALVCGLLFAFAMVFSGLFASVT---------------AACTAGALILVGLIMVRNIRDIEW-KDP 391
WP_016339217 349 ESTTGVSQGARTGFSSIITALMFLVAIALFPVFKLIT---------------PAIVGAATIFVGSLMIMQIKDIEW-LKP 412
WP_081695863 380 ESAAGIEQGAKTGLAAVVNGILFLLAIIMFPIFKLIP---------------QPITSAACVYIGIMMIKEAAHVEW-DKP 443
WP_045109494 317 ESAVASSLGAKTGISAITVAVMFLVSMFLFPVFSIFT---------------SAIVAPALVVIGIYMIKNLANINW-NKK 380
WP_025734736 358 ESCVGIMQGARTGFANIITSFGFLLSLALFPIFRMMP---------------DCLSGAATVFIGTVMIKSIMDIEW-SKT 421
WP_025734791 359 ESSAGISQGAKTGVVALVNVALFGVAIALFPIFATIP---------------TVVTGAACVFIGILMVLHISEIEW-DKP 422
WP_106720223 319 ESSTGIEQGARTGLASVVVAILFILSIFLYPVLSIFNgvvvgvngfgdaivySPVTAMALIMVGTLMFAQLKDIDW-EDT 397
WP_015772262 450 EIAVPAFLTMIVMPFTYSITDGIGMGFLVWVIIKIVKGKGREIHPLMWVTTAMFIIYFVLG 510
WP_013346235 396 ASRIAAFFTIMFTILSFSPANGMAMGFISYAFAMVVAGKAREVHPIIYALSLIFVAYLVML 456
WP_003774898 398 ENIIPAFLTIVMMPLTGSIALGLTLGFISYEMCMIFAGRGKELPKIMHFITLISIAYICTL 458
WP_015492263 392 VLCFSSIITVFMMGLAGSITDGIGIGIMAYVIGYVAMRKEKEISPTMWVLFLIFTGYFVIH 452
WP_016339217 413 EFAISAFFTIIIMIVTFSITNGIAVGFIFYAIVSLICNKGKGVGIPIYVLDLFFIGYFIAF 473
WP_081695863 444 EFLVPTFLSILFMIATYEIANGVAMAFIGYSFMMMITGKAKKVHPAVYCLSVLFVIYFIAF 504
WP_045109494 381 ESAIPVFFIMVFSLLTFSPANGMAMGFISYCFVMLVQGDGKKVHPIIYSLALLFIVYLALS 441
WP_025734736 422 EIGLGAFFTILFMIITYSIANGIVVGIIAYSIGAIATKRAKQVHYLVWILDFVFVIYLVAY 482
WP_025734791 423 EFAVPAFLGILFAITTFTIVNGVAVTILAYAFVMIITNKAKKVHILIWPLCLCLIAYFVAF 483
WP_106720223 398 AIVITGFFTIIVMILSYSIATGIAVGFIFYPIIMLAQGKAKKVNPVMYGLALLFVLYFVLH 458
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