1352001 111 SKKLYELLSDFntAYYDDENMILGSNLfSKNTYSRqpyvANGYIGSRIpNIGFGYALDtlnfytdapgalnngwplrnhR 190 baker's yeast 15672410 1 -----MTEKDW--IIQYDKKEVGKRSYgQESLMSL----GNGYLGLRGaPLWSTCSDN---------------------H 48 Lactococcus lacti... 1731240 525 lqeavqhdDPW--TLVFHGYDPGQERL-REALCAV----GNGYLGSRGcAPESAESEA---------------------H 576 Mycobacterium tub... 15829105 1 MPKLFYDLKNF--KIYQKGYDPLLSGK-TESIFAQ----GNGYLGIRA--VDEENSHF---------------------H 50 Mycoplasma pulmonis 14590619 1 -------------MRFQFGFSKEDEQV-LGTILTL----GNGQLGVRG-EFELERS------------------------ 37 Pyrococcus horiko... 15801854 1 ------MTRPV--TLSEPHFSQHTLNK-YASLMAQ----GNGYLGLRA-SHEEDYT-R---------------------Q 44 Escherichia coli ... 17228553 5 cpsrdFIYQDW--ILSETKFNPEQSHS-RGTVFTI----GNGYLGTRG-SLEEGHA-R---------------------G 54 Nostoc sp. PCC 7120 17232481 12 SLEPLLDSHEW--NVIETEFNPTQLHH-KETVFTL----SNGYLGTRG-SLEEGYQ-E---------------------D 61 Nostoc sp. PCC 7120 16802024 1 ------MRK-----IIEKEFALNYLNK-YGSQMTV----GNGYLGVRG-ALEEEYP-E---------------------Q 41 Listeria innocua 3025085 1 ------MTRPV--TLSEPHFSQHTLNK-YASLMAQ----GNGYLGLRA-SHEEDYT-R---------------------Q 44 Escherichia coli
1352001 191 FAGAFVSDFYCLQPKLnsTNFpeldDVGYSTVISSIPQWTNLQFSLVNdsKWFNPQNVtldDVTNYSQNLSMKDGIVTTE 270 baker's yeast 15672410 49 YPGLYVAGVFNRTSTE--VAG----HDVINEDMVNWPNPQLIKVYIDG--ELVDFEAS-----VEKQATIDFKNALQIER 115 Lactococcus lacti... 1731240 577 YPGTYVAGVYNQLTDH--IEG----CTVDNESLVNLPNWLSLTFRIDGg-AWFNVDTV---ELLSYRQTFDLRRATLTRS 646 Mycobacterium tub... 15829105 51 KEDFFINGLFNRGDE------------NEVSELANLSNTIQLKILIDG--RVFETSH-----VSSYYKELDLKNGKLKRI 111 Mycoplasma pulmonis 14590619 38 PYGTIVSGVYDYTP-------------YFYRELVNGPRTIGMIIIIDG--ELINPSSQ---KVKEFQRELDIEKGLLRTH 99 Pyrococcus horiko... 15801854 45 TRGMYLAGLYHRAGK------------GEINELVNLPDILGMEIAING--EVFSLSH------EAWQRELDFASGELRRN 104 Escherichia coli ... 17228553 55 LPATFIHGVYDDVP-------------VVYTELANCPDWLPMIIAING--DRFRMDQG---EVLHYERKLDVSQGLLSRS 116 Nostoc sp. PCC 7120 17232481 62 FPATMIHGIYDDTQ-------------ISHTELVNCPHWLPLVVEVAG--ERFSMNSG---EVLHYERRLDLRLGLLSRD 123 Nostoc sp. PCC 7120 16802024 42 VRGMYVAGIYNRPSG------------SVSSELVNLPDVTRFQVTLDG--EVFSMQAG---KVHGYERFLDMNTGELVRK 104 Listeria innocua 3025085 45 TRGMYLAGLYHRAGK------------GEINELVNLPDVVGMEIAING--EVFSLSH------EAWQRELDFASGELRRN 104 Escherichia coli
1352001 271 LDWLN---SQIHVKSEIWAHRHIHPLGVVSLEISLNTDhlpsDFDSLDVNIWDILDFNTSHRtVLHSTGTDEKNNAVFMI 347 baker's yeast 15672410 116 YQVKLakgN-LTLVTTKFVDPINFHDFGFVGEIIADF-----SCKLRIETFTDGSVLNQNVE-RYRAFDSKEFEVTKISK 188 Lactococcus lacti... 1731240 647 LRFRDaggRVTTMTQERFASMNRPNLVALQTRIESENW----SGTVDFRSLVDGGVHNTLVDrYRQLSSQHLTTAEIEVL 722 Mycobacterium tub... 15829105 112 LRYKQk-dKFFELIFERLVDQENKQLYAQKITIKQLKGl---ESEIKIFPLIDGQSTNRGIQhFKEGKKLLISDALIQYQ 187 Mycoplasma pulmonis 14590619 100 LEIETkngNKILYKSTRIVHMKRKNLILLDFELKASKG-----GIAVVVNPIEFNTANPGFI--DEIMIKHYRVDSIKET 172 Pyrococcus horiko... 15801854 105 VVWRTsngAGYTIASRRFVSADQLPLIALEITITPLDA----DASVLISTGIDATQTNHGRQ-HLDETQVRVFGQHLMQG 179 Escherichia coli ... 17228553 117 LRWRSpsgSIIDIHFERFASLADHHILGQRCQITAHDG----DCLVEIQASINGYAENQGFN-HWEGIDQGKTEQGIWLQ 191 Nostoc sp. PCC 7120 17232481 124 VRWRSpqgHTLDLHFERFASLADQHVLAIRCQITSVDF----TGEITVTARFDAEPKTQGVP-HWQTLNQGGVDQILWLQ 198 Nostoc sp. PCC 7120 16802024 105 IIWENsagDKYQLNFYRFASKVVKHVIAARVEITPLNG----CAKVKIKTGIDAQQTNFGTQ-QLAESSLRIFDEELMVG 179 Listeria innocua 3025085 105 VVWRTsngSGYTIASRRFVSADQLPLIALEITITPLDA----DASVLISTGIDATQTNHGRQ-HLDETQVRVFGQHLMQG 179 Escherichia coli
1352001 348 VQPDNVPSSNCAIYSTCTVKYENSTNPIN----SSESFEEKDVSSNIYNVILTEDQPKIIVHKYVGIMSTEfNKNkeQQD 423 baker's yeast 15672410 189 GLLVAKTRTS---EIELAIASKSFLNGLA----FPKIDSENDEILAEAIEIDLQKNQEVQFDKTIVIASS--------YE 253 Lactococcus lacti... 1731240 723 ADSVLLRTQTSQSGIAIAVAARSTLWRDGqrvdAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSR-D-----AA 796 Mycobacterium tub... 15829105 188 EQTNQSNFWAIHNMKIKVFENKKLLECDn----DNFVIKMARRQIGYEIKSKVSIGKDFVLEKIMSVNSLTkDVEnnFDN 263 Mycoplasma pulmonis 14590619 173 EEGVYARVKTLDNKYTLEIASSLVPSEY-----TSRSTFRTDNEIGEIYIVKLKPGKTYKFTKYVTVSKG--------A- 238 Pyrococcus horiko... 15801854 180 IYTTQDGRSD----V--AISCCCKVSGD-----VQQCYTAKERRLLQHTSAQLHAGETVTLQKLVWIDWRD-DRQavLDE 247 Escherichia coli ... 17228553 192 SRTRGTHIEI----G--MAAKMTISGAE-----TALQVSIVPGYPTISASFLAKSQQTITVEKLVTVFTS--------RE 252 Nostoc sp. PCC 7120 17232481 199 SQTLHSGVGL----G--MSAKLIIDGDE-----TAVVSVKNAGIPTLETTFECNPGKTVIVEKIVTVFTS--------RE 259 Nostoc sp. PCC 7120 16802024 180 EYETIESKQ--------RITVATKVS-------QKGVFTAKNRQLMTEVEQEIAANQTFALEKISLVKTS-------LDE 237 Listeria innocua 3025085 180 SYTTQDGRSD----V--AISCCCKVSGD-----VQQCYTAKERRLLQHTSAQLHAGETMTLQKLVWIDWRD-DRQaaLDE 247 Escherichia coli
1352001 424 NTNIGLAKMIALNSKGNYEKLLSSHKRAWYDLYNDAFIEIPS-DSLLEM---TARSSLFHLLANTRdynvSSDRGLPVGV 499 baker's yeast 15672410 254 SKNP-VEFVLTELSATSVSKIQENNTNYWEKVWSDADIVIESdHEDLQR---MVRMNIFHIRQAAQhg-aNQFLDASVGS 328 Lactococcus lacti... 1731240 797 TLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTG-NTEELR---LVRLHLLHLLQTISp--hTAELDAGVPA 870 Mycobacterium tub... 15829105 264 FYQQSLEN-AKKIDKLTFDDFEKNSQKQFDKIYSQFDVQIEG-NKSAQYdflAMKFALYHMNIFVP-----NDPRLSVGA 336 Mycoplasma pulmonis 14590619 239 ALEE-----LKDVKRLGFEKLYEEHINSWKRIWEKVKVEIEG-DKDLEN---ALNFNIFHLIQSLP-----PTDKVSLPA 304 Pyrococcus horiko... 15801854 248 WGSASLRQLEICAQ-QSYDQLLAASTENWRQWWQKRRITVNGgDAHDQQ---ALDYALYHLRIMTP----AHDERSSIAA 319 Escherichia coli ... 17228553 253 VNKPVTAAQEKLAQLTNYTTLLTANKQAWDEVWQKSDIYIEG-DPKAAF---AVRYNLFQLLIAAP----SHDEKVSIPA 324 Nostoc sp. PCC 7120 17232481 260 TETPIAAALERLADEPRYTTLLAAHIAAWEQVWQNSDIIIEG-DRQAQL---SVRYNLFQLLSVAP----RHDDHVSIAP 331 Nostoc sp. PCC 7120 16802024 238 VD---V-EFP--N--ETYAELKANSEKAWADFWEHAGVRVEStNDFDQF---ALDFACYHLEIMTP----KDDFRCSVGA 302 Listeria innocua 3025085 248 WGSASLRQLEMCAQ-QSYDQLLAASTENWRQWWQKRRITVNGgEAHDQQ---ALDYALYHLRIMTP----AHDERSSIAA 319 Escherichia coli
1352001 500 SGLSSDSYGGMVFWDADIWMEPALLPFFPNVAQNMNNYRNATHSQAKLNAEKYGYPGAIYPWTSGK--YANCTSTGPCVD 577 baker's yeast 15672410 329 RGLTGEGYRGHIFWD-EIFVLPYYAANEPETARDLLLYRINRLTAAQENAKVDGEKGAMFPWQSGLi-GDEQSQFVHLNT 406 Lactococcus lacti... 1731240 871 RGLNGEAYRGHVFWD-ALFVAPVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSd-GSEVSQQLHLNP 948 Mycobacterium tub... 15829105 337 KGLSGEGYQGHCYWDTEFFVMPNYLFTNPKIARNLLEYRYLGINGARDKAKEKNLLGAQYPWEAALpeEGEVTPYWGQPN 416 Mycoplasma pulmonis 14590619 305 RGIHGFGYRGHIFWDTEIYALPFFIFTMPKEARRLLLYRCNNLDAAKENAKMNGYQGVQFPWESADd-GREATPSEIPLD 383 Pyrococcus horiko... 15801854 320 KGLTGEGYKGHVFWDTEVFLLPFHLFSDPTVARSLLRYRWHNLPGAQEKARRSGWQGALFPWESARs-GEEETPEFAAIN 398 Escherichia coli ... 17228553 325 KTLSGFGYRGHIFWDTEIFILPFFTFTQPTLARNLLSYRYHTINGARRKASHYGFKGAMYAWESADt-GDEVTPRWALPD 403 Nostoc sp. PCC 7120 17232481 332 KTLSGFAYSGHIFWDTEIFILPFLTFTQPDLARNLLTYRYHTLPGARRKAQEAGYQGAMFAWESATt-GDEVTPRWVPGA 410 Nostoc sp. PCC 7120 16802024 303 KGLTGEGYKGHVFWDTEIFIMPFFLYNKPEIAKQLLEYRYLHLKEAKEKALKNGYNGALYPWESAFs-GEEETPEFAAIN 381 Listeria innocua 3025085 320 KGLTGEGYKGHVFWDTEVFLLPFHLFSDPTVARSLLRYRWHNLPGAQEKARRNGWQGALFPWESARs-GEEETPEFAAIN 398 Escherichia coli
1352001 578 Y-------------EYHINVDVAMAsFSIYLNGHEgiDDEYLRYTTWPIIKNAAQFFTAYVKYNSSLGLYETYNLTDPDE 644 baker's yeast 15672410 407 Vnnewep--dnsrrQRHVSLAIVYN-LWIYSQLTE--DESILTDGGLDLIIETTKFWLNKAELG-DDGRYHIDGVMGPDE 480 Lactococcus lacti... 1731240 949 Rsgrwtp--dpsdrAHHVGLAVAYN-AWHYYQVTG--DRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDE 1023 Mycobacterium tub... 15829105 417 IttgeqvpiasreqEIHVPGDVAFA-VNQYFEATN--DQKFMNDMGYEMIFDTAMFWASRAEC--NNDICQITNVMGPNE 491 Mycoplasma pulmonis 14590619 384 MlgrkivriytgeeEHHITADIAYI-VDFYYQVSG--DLEFMNRCGLEIIFETARFWASRVEFE-EGKGYVIKKVIGPDE 459 Pyrococcus horiko... 15801854 399 IrtglrqkvasaqaEHHLVADIAWA-VIQYWQTTG--DESFIAHEGMALLLETAKFWISRAVR--VNDRLEIHDVIGPDE 473 Escherichia coli ... 17228553 404 DyygedvriwcrdrEIHNSADIAYA-VWQYWQATG--DDDWMGDYGAEIILDAAIFWSSRVEYNSQGDRYEIRGVIGTDE 480 Nostoc sp. PCC 7120 17232481 411 Ngeliri--wcgdlEVHITADVAYA-VWHYWQTTN--DDEWMHDYGAEIILDTAVFWESRVQWNEQRHSYDILDVIGPDE 485 Nostoc sp. PCC 7120 16802024 382 IrtgtrqkvasaisEHHLVADIAYA-VCEYEAATG--DAQFMSDCGAELLLETAEFWISRATN--RNGRLEILDVIGPDE 456 Listeria innocua 3025085 399 IrtglrqkvasaqaEHHLVADIAWA-VIQYWQTTG--DESFIAHEGMALLLETAKFWISRAVR--VNDRLEIHDVIGPDE 473 Escherichia coli
1352001 645 FAN--------HINNGAFTNAGIKTLLKWATDIGNHLgevvdpkWSEISKDIyiprsssNITLEYSGMnssveikQADVT 716 baker's yeast 15672410 481 YHEaypg-qegGICDNAYTNLMLTWQLNWLTELSE-------------K-GF-------EIPKELLEK-------AQKVR 531 Lactococcus lacti... 1731240 1024 FHSgypgneydGIDNNAYTNVMAVWVILRAMEALDLLpl---tdRRHLIEKL-------GLTTQERDQ-------WDDVS 1086 Mycobacterium tub... 15829105 492 YKG--------NIDNNNFINLIAKRNLELALKHKKILe-----sTSEARQIL-------NSVLEKIPYpi----nWEKIE 547 Mycoplasma pulmonis 14590619 460 YHE--------HVNNNFFTNLMAKHNLELAIRYFRESknr--epWKKIVEKL-------NIREEEVEK-------WEEIA 515 Pyrococcus horiko... 15801854 474 YTE--------HVNNNAFTSYMARYNVQQALNIARQF--------------G-------CSDDAFIHR-------AEMFL 517 Escherichia coli ... 17228553 481 YHE--------FVHNNTFTNRMVQWHLEKALTVAEWLrhnfperAKALEDKL-------QLTPELETL-------WQDII 538 Nostoc sp. PCC 7120 17232481 486 NHD--------RVNNNAFTNLMVQWHLQSALALWDWFkhvypekAAQLVEQL-------NLTTERLHC-------WAEIQ 543 Nostoc sp. PCC 7120 16802024 457 YTE--------HIDNNTYTNYMAHYNVKMALEWNR-------------------------DNEAFQSR-------AKAFL 496 Listeria innocua 3025085 474 YTE--------HVNNNAYTSYMARYNVQQALNIARQF--------------G-------CSDDAFIHR-------AEMFL 517 Escherichia coli
1352001 717 lmvYPLGYINDESILNNAIKDLYYYSErqsasgpAMTYPVFVAAAAgllnhgSSSQSYLYKSVLpylrAPFAQFSEQSDd 796 baker's yeast 15672410 532 ---KKLYLDIDEN-GVIAQYAKYFELK-------EVDFAAYEAKYGdi---hRIDRLMKAEGIS----PDEYQVAKQAD- 592 Lactococcus lacti... 1731240 1087 ---RRMFVPFHD--GVISQFEGYSELA-------ELDWDHYRHRYGni---qRLDRILEAEGDS----VNNYQASKQAD- 1146 Mycobacterium tub... 15829105 548 yvfEKMYLQKPNENLIIAENDQFLKLS-------RVDISEFQFLGDag---tKLFNTIEGNK------KLNSQIVKQAD- 610 Mycoplasma pulmonis 14590619 516 ---KNMYIPRKID-GVFEEFDGYFELM-------DFEVDPFN--IG------EKTLPEEIRN-N----IGKTKLVKQAD- 570 Pyrococcus horiko... 15801854 518 ---KELWMPETQPDGVLPQDDSFMAKP-------AINLAKYKAAAG------KQTILLDYSRAE----VNEMQILKQAD- 576 Escherichia coli ... 17228553 539 ---KKICIFYDSSTGLIEQFEGFFQLQ-------DINLEDYEPRQ--------RSMQAILGIET----ANQHQVLKQPD- 595 Nostoc sp. PCC 7120 17232481 544 ---ERIFVNEDLTTGLIEQFEGFFQLE-------DVNLADYEPRT--------KSLQGLLGIEA----TSQKQILKQPD- 600 Nostoc sp. PCC 7120 16802024 497 ---KNLYLPVANEKGLIPQDDTFLQKD-------WINLDKYKAAQG------TQGILLDYSRQE----VNELQILKQAD- 555 Listeria innocua 3025085 518 ---KELWMPEIQPDGVLPQDDSFMAKP-------AINLAKYKAAAG------KQTILLDYSRAE----VNEMQILKQAD- 576 Escherichia coli
1352001 797 nFLTNGLTQPafpfltanggflqsILFGLTGIRYSYEVDPDTKKINRllRFNPIELPLLPGGIAIRNFKYMNQVLDIIID 876 baker's yeast 15672410 593 -TLMLIYNLGqehvtk--lvkqlaYELPENWLKVNRDYYLARTVHGS--TTSRPVFAGIDVKLGDFDEALDFLITAIGSD 667 Lactococcus lacti... 1731240 1147 -ALMLLYLLSsdelig--llarlgYRFAPTQIPGTVDYYLARTSDGS--TLSAVVHAWVLARAN-RSNAMEYFRQVLRSD 1220 Mycobacterium tub... 15829105 611 -VVLSMFIFK--------------ELFSKKIIEANLDFYLPVTTHDS--SLSATTYTIVAIDLRKMDIAQKLFKYSIDID 673 Mycoplasma pulmonis 14590619 571 -VIMAQYLLK--------------DYFSPEEIKSNFNYYIRRTTHAS--SLSMPPYAIIATWIGEVKIAYEYFKRCANID 633 Pyrococcus horiko... 15801854 577 -VVMLNYMLP--------------EQFSAVSCLANLQFYEPRTIHDS--SLSKAIHGIVAARCGLLTQSYQFWREGTEID 639 Escherichia coli ... 17228553 596 -VLMLLYLMRps----------aeFPYNEKALKSNWDYYAPRTDITYgsSLGPAIHGILASDLGKSATAYERFMQALMVD 664 Nostoc sp. PCC 7120 17232481 601 -VLMLLYLLR--------------QAYDYNTLKVNWDYYTQRTDHTYgsSLGPAIHAVLACDLNNPTEAYTHFLRAALVD 665 Nostoc sp. PCC 7120 16802024 556 -LVMLFYLFP--------------QMFPPETVKKNLDYYEKRTIHDS--SLSKAIHAIVENRTGNREQAYQFFQEACLID 618 Listeria innocua 3025085 577 -VVMLNYMLP--------------EQFSAASCLANLQFYEPRTIHDS--SLSKAIHGIVAARCGLLTQSYQFWREGTEID 639 Escherichia coli
1352001 877 DHNGTivhKSGDVPIHIKIpnRSLIHDQDINFYNGsenerkpnLERRDVDRVGDPMRMDRYGTYYLLKPKQELTVQLFKP 956 baker's yeast 15672410 668 YYDIQg--GTTAEGVHIGV--MGETLEVIQNEFAG--------LSLREGQFAIAPYLPKSWTKLKFNQIFRGTKVEILIE 735 Lactococcus lacti... 1731240 1221 IADVQg--GTTQEGIHLAA--MAGSIDLLQRCYSG--------LELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRIS 1288 Mycobacterium tub... 15829105 674 LGTNF---RSSDQGIHSGS--LAAIWQTIVFGFGG--------FRFYNNQIHINPILAKGWTKLSYSVIVKNIKLKVNVY 740 Mycoplasma pulmonis 14590619 634 LKNVY---GNTAEGFHLAT--AGGTWQVLVRGFCG--------LNVKGNKIELNPNLPEKWKYVKFRIFFKGSWIEFKIS 700 Pyrococcus horiko... 15801854 640 LGADP---HSCDDGIHAAA--TGAIWLGAIQGFAG--------VSVRDGELHLNPALPEQWQQLSFPLFWQGCELQVTLD 706 Escherichia coli ... 17228553 665 LEDTR---GNANDGIHGAS--AGGIWQAVIFGFGG--------IQFTEKGPVANPHLPPTWTRLKFQLHWRGQWYPFDLP 731 Nostoc sp. PCC 7120 17232481 666 LEDVR---LNAAEGIHAAS--AGGVWQAVVLGFGG--------VRMTQFGPMACPNLPPTWKRLKFKLQWRNEWYEFDLQ 732 Nostoc sp. PCC 7120 16802024 619 LGDEP---HSSDDGLHAAS--LGAIWLAVVFGFAG--------IDTSGELLEIAPDLPDAWRFVKFEFMWKG-ETILVEI 684 Listeria innocua 3025085 640 LGADP---HSCDDGIHAAA--TGAIWLGAIQGFAG--------VSVRDGELHLNPALPEQWQQLSFPLFWQGCELQVTLD 706 Escherichia coli
1352001 957 Gl-------NARNNIAENKQiTNLTAGVPGDVAFSALDGNNYTHWQP 996 baker's yeast 15672410 736 N--------GQLLLTASAD----LLTKVYDDEVQLKAGVQTKFDLK- 769 Lactococcus lactis subsp. lactis 1731240 1289 G--------RSATLTAESGDaEPIEVECRGHVQRLRCGHTIEVGCSR 1327 Mycobacterium tuberculosis 15829105 741 P--------KYFEIIKNGED--NLDIFVNGKEVTLDKVKNVFEVNFD 777 Mycoplasma pulmonis 14590619 701 R--------KKVRARMLEGS-RKVKISSFGKEVDLYPGKEVVIVAN- 737 Pyrococcus horikoshii 15801854 707 AqriairtsAPVSLRLNGQLiSVAEESVFCLGDFILPFNGTATTHQE 753 Escherichia coli O157:H7 EDL933 17228553 732 Ggq-----eAGGREQGAGEQgAGEQREVRAEEASARNFGGSSSLKAF 773 Nostoc sp. PCC 7120 17232481 733 Pet-----aMAMVTQEA-------QVPVFATVQAVMSNG-------- 759 Nostoc sp. PCC 7120 16802024 685 ---------APNTLQLSKNTkSMLELVIYGE-KQQLTDTLTIKMEQK 721 Listeria innocua 3025085 707 AqriairtsAPVSLRLNGQLiTVAEESVFCLGDFILPFNGTATKHQE 753 Escherichia coli
Jiyao W et al.(2023). "The conserved domain database in 2023.",