2CH6,2CH5


Conserved Protein Domain Family
ASKHA_NBD_NAGK_meta
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cd24078: ASKHA_NBD_NAGK_meta 
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins
NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. Members in this family are mainly from metazoa.
Links
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Statistics
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PSSM-Id: 466928
Aligned: 30 rows
Threshold Bit Score: 376.151
Created: 27-Jun-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is located in a cleft between domains I and II of N-terminal domain (NTD) of N-acetylglucosamine kinase.
  • Structure:2CH6; Homo sapiens N-acetylglucosamine kinase in complex with ADP and glucose, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##                                                                      
2CH6_A      4 IYGGVEGGGTRSEVLLVSEd--GKILAEADGls----tNHWLIGTDKCVERINEMVNRAKRKAGvdp-----lvPLRSLG 72  human
TNN07999    4 LIGGIEGGATISRMVLLDFe--GNQLGYSEGps----lNPWLLGLEEAAKRILILVKDVLINSNrkp-----tePLAHLS 72  Schistosoma japonicum
CBY08774    3 LYVGVEGGGTHTTAIVVNEh--GKQLAEEIGeg----tNVHLIGLELLTDRLNELLEKLWLQLNvpe-----gtQFDCVG 71  Oikopleura dioica
NP_650448   3 YFGGVEGGATHSRLVICDEs--GQSVGATSGlg----tNHWGIGIPECARRIADMVERAKEEAGipk-----etPLTSLG 71  fruit fly
NP_494789 195 LYAGIEGGATGSKLVIIDAdtnQRYTSSTEGt------NFFLTDHTIVCKRIADWILEVFEKEKld------ikNLKALG 262 Caenorhabditis ele...
GAU91988   13 YFMGVEGGGTSSNAVLLDEk--GKLLATCKGdt----tNMWNIGIPKTCENIIAMVQDIRKTAKldd-----svQISGLG 81  Ramazzottius varie...
VDP12456   12 YFAGVEGGATKTVLQVMDDa--GRVLAVKTGma----tNLYLCSTDEASKRIYDLLISAVQEAGlsv-----haKLKCIG 80  Soboliphyme baturini
ACO11408    3 YYGGVEGGGTKTSLVIYDAn--AKELSRVLDgp---stNFFLIGKEEAVKRLVEIIKECLKKAGlpi-----ntTLESLG 72  Caligus rogercresseyi
CBY24730    3 IFIGIEGGATKSNGVLVDGn-tGGILKEITGgp----aNVWTEDLSIVLSRLEKMIKFLYMSSSsdl----pitEKVSLG 73  Oikopleura dioica
RNA11889    6 LFAGIEGGATKTILKIIDEy--GNVLVESATgpsnpwqFNEKDGFKIVAKNITQIVNEALDKISnrsllgkeiyKLESLA 83  Brachionus plicatilis

Feature 1          #                            #                  # #####                    
2CH6_A     73 LSLSGGdqEDAGRILIEELRDRfpyLSESYLITTDAAGSIATAt--pDGGVVLISGTGSNCRLINpd---------gsES 141 human
TNN07999   73 LSLSGAdtEANQNELVNAIKDLcpnVAHEIHICNDSIGAFLTVc--eKAAIVLISGTGSICSYVRen---------ltFQ 141 Schistosoma japonicum
CBY08774   72 LAISGAqdGMEDLIKEHLQDACg-eLFREISIYDDTYGSVFTCs---NGGIVLIAGTGSNCQLINdd---------fsGA 138 Oikopleura dioica
NP_650448  72 LSLSGCeqEATNRELEQELRTTfpgLAQNYAVSSDTMGSMYTAs--sIGGMVLISGTGSNCLLRNpd---------gsTS 140 fruit fly
NP_494789 263 LGLSGAedEEFNKKFVDYFRQNhgnVTENFYLTSDAVMTLLANfpgeENGIVLIAGTGSSCRLKIrd---------gsVK 333 Caenorhabditis ele...
GAU91988   82 LCLSGAddVKMNNELVEALRTEygnPATEYVIENDTIGSMATAlp-dLAGIVIIAGTGSNCVLSNpd---------gsQH 151 Ramazzottius varie...
VDP12456   81 MALSGAenEDLNTRFIDGFRTQypgVTDFCYVTSDSVGTIATAf--pNGGIVLIAGTGSSCRLLNpd---------gvMY 149 Soboliphyme baturini
ACO11408   73 LCLSGGenEKTNEDIKSMIMSHg--VAKSLIVRSDTLGPLATIg---NKGLVLIAGTGSNLLTAS-------------GA 134 Caligus rogercresseyi
CBY24730   74 LTLAGAssEAVQANIALQIKSRv-kFVDRIVVDTDAVAPIFMGl---KKGTVLISGTGSSCLFISen---------giEK 140 Oikopleura dioica
RNA11889   84 CCLSGTgtKVARERLTQEINNIh--IDYKVFVTNDSLATVFSAf--eNGGMVLISGTGSYCVLVNpldknftsieeieIF 159 Brachionus plicatilis

Feature 1        ###    #   #                                                               ##
2CH6_A    142 GCGGWGHMmGDEGSAYWIAHQAVKIVFDSIDNleaa-----phdiGYVKQAMFHYFQvpd-rlGILTHLYRDFdKCRFAG 215 human
TNN07999  142 RIGGYGHLlGDSGSAYWISQRVVKRLINADDKiidt-----tynlDNVRQVIYAYFNven-nlELLQHFYTNFsKDKIAA 215 Schistosoma japonicum
CBY08774  139 RCGGWGHFiGDEGSAFFITHRALKTVFDHEDNliec-----efstARVFEEMKLYFGvedrgqMLDVFYAAKFdKSNYAG 213 Oikopleura dioica
NP_650448 141 NCGGWGNFlGDEGSAWYISYRAVKVVFDHMDNfeqs-----aapvEKTWSLIKEHFSlet-rlDMLPHCYAKFdKPFFAN 214 fruit fly
NP_494789 334 GAGGWGHQiGDGGSAFWIARTAIQMLFDAEDGfeen------fntDVIKQLLFKHYNitd-ktRMLDYLYSKFeKHKIAD 406 Caenorhabditis ele...
GAU91988  152 KCGGWGHLlADEGSAYWIATRAIKILFEADDNyrpf-----dfniDVLRGQIFDFFKvtq-rsEILPFYYSPFqKSVIAS 225 Ramazzottius varie...
VDP12456  150 GCGGWGHLiGDEGSAYWISTEAIRAVFAAEDGftll-----pydvSCVKEKMLRFFHlsd-ksQILELLYKNFeKAKIAG 223 Soboliphyme baturini
ACO11408  135 RCGGWGSFiGDEGGAHWIAQLATTWIFHSEDNfrhkispfskdqlFPIKSIFLEYFKlse-isDILTHCYDSYsKSHYAG 213 Caligus rogercresseyi
CBY24730  141 RSGGLGHMlGDEGSAYWIATKAIKLVLDKADEipnn-----vldtSLVEREIKNYFKied-lkDLMKIFHENFdKAKIAG 214 Oikopleura dioica
RNA11889  160 SSGGWGSAlGDEGSAFWISTQLIKHFIKINDNiakpd---dinefSELKEIILEHFQiks-lrEILPYFYENKqSDKIAA 235 Brachionus plicatilis

Feature 1      ##  #                                                                     ### #
2CH6_A    216 FCRKIAEGAqq---------------------gDPLSRYIFRKAGEMLGRHIVAVlpeidpvlfqgkiGLPILCVGSVWK 274 human
TNN07999  216 LCEPLSQIArn---------------------gDQLSKNVFHDAGVQLARHVRAAlyyvvmdsvcqnqNLTVVCCGSVFK 274 Schistosoma japonicum
CBY08774  214 FCKSLAMLAke---------------------gDELSLSCFVEAGRLLAQHIVAIrrnmtdemisqkgGPVVICVGSVWK 272 Oikopleura dioica
NP_650448 215 LCKKLSQNAen---------------------gDELARSLFREAGVHLARMILALlpnvhq-dlvksgDLSVVCVGSVWS 272 fruit fly
NP_494789 407 FTVSLAERTd-----------------------DAAVAEAFRRAGDVLGKHVRTVakylt---nedrkVLSIVQIGGVFQ 460 Caenorhabditis ele...
GAU91988  226 MAAGIAKGAke--------------------hkDPLCQYLYHEAGLRLAEHVRAVtpliqnelltrpgGCPVVCVGSVWK 285 Ramazzottius varie...
VDP12456  224 FCKVLAQGVkdyfifdagtidqncfkteihaakDLFIQHLFHKAGRMLGKHVLAItahadkallrragGVPVVIIGSVWK 303 Soboliphyme baturini
ACO11408  214 VTKLIAELTar--------------------tnDPIGRRLFSEAGSALAHHILAVeds-------lelDLDVLCVGSLWL 266 Caligus rogercresseyi
CBY24730  215 FTERLAITAnd--------------------knDPVAKICFSSAGSELAKLVVSMentle---ngdevPPEILCQGSVWN 271 Oikopleura dioica
RNA11889  236 LTEKLAKIAsl--------------------geKRTLLDLFEQAGYELAILVVSLipnft---dvgkdELEIVCTGSVFK 292 Brachionus plicatilis

Feature 1     #                                               
2CH6_A    275 SWeLLKEGFLLALTQgreiqaqnffSSFTLMKLRhsSALGGASLGARH 322 human
TNN07999  275 SWdLMRDGFYEYLKPsndd---qwtGTLNLVQLKhsAAYGAARLSNYF 319 Schistosoma japonicum
CBY08774  273 SWgFMKESFVNVLQKts------klKELTLVRPKvtSAYGAARLACRE 314 Oikopleura dioica
NP_650448 273 SWdLLQEAFISELAKtt------idFDLKLVRITksSAYGACYLGADS 314 fruit fly
NP_494789 461 SWdALQQGFVASLSGsg-------iEKIVMYEPSdsPAVGAAVLAAKE 501 Caenorhabditis elegans
GAU91988  286 SWdLLKDGFLEGLNHc--------vPALRMIKLNgsSAYGAAFLAARK 325 Ramazzottius varieornatus
VDP12456  304 SFdYLKQGKYQNAEHrq-------fDEITLYVPKasPALGAVYLAAKK 344 Soboliphyme baturini
ACO11408  267 SWeLLMEGFMGTLERhat-----kiKSLRLISLKepSALGAAYLGQWK 309 Caligus rogercresseyi
CBY24730  272 SWnLLKESFIQGMKLhs------klTALSFVQVSacCAYGAARFASIK 313 Oikopleura dioica
RNA11889  293 SWsLLKPGFIRGLKTqs------llTKFRLVKIDgnSSIGACVLSSKL 334 Brachionus plicatilis

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