3FUB,2V5E,1AGQ


Conserved Protein Domain Family
TGF_beta_GDNF
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cd19380: TGF_beta_GDNF 
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transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins
GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Links
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Statistics
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PSSM-Id: 381650
Aligned: 9 rows
Threshold Bit Score: 165.021
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptidehomodimer
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:3FUB; Rattus norvegicus GDNF in complex with GFRalpha1, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #            ### #                                             ###### #
3FUB_B        38 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDaAETTYDKILKNLSRNRRLVSDk-vGQACCRPIAFDDDLSFLDD 116 human
2V5E_B         5 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDaAETTYDKILKNLSRNRRLVSDk-vGQACCRPIAFDDDLSFLDD 83  human
1AGQ_A        39 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCEaAETMYDKILKNLSRSRRLTSDk-vGQACCRPVAFDDDLSFLDD 117 Norway rat
P39905       115 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDaAETTYDKILKNLSRNRRLVSDk-vGQACCRPIAFDDDLSFLDD 193 human
AAF26684     120 NRGCVLTAIHLNVTDLDLGYETKEELIFRYCSGSCDaVETTYDKILKNLTRKKKLVNDk-vRQACCRPTAFDDDLSFLDD 198 chicken
Q98TU0       139 GRGCLLKEIHLNVTDLDLGYRTKEELIFRYCSGPCHdAETNYDKILNNLTHNKKLDKDt-pSRTCCRPIAFDDDISFLDD 217 zebrafish
Q06PM8       131 NKGCVLREIHLNVTDLGLGYETKEELKFRYCSGSCNnPETTYDQILKNLTIRKKLVNDk-vKQACCRPIAFDDDLSFLDD 209 African clawed ...
XP_006007492 126 NRGCVLREIHLNVTDLELGYKTKEELIFKYCSGSCDaPETTYDIIVKNLTKKKKLVKDe-vKQACCRPTAFDDDLSFLDD 204 coelacanth
XP_007910431  60 NKGCVLKEIHLNITDLELGYDTQEELMFKYCSGSCEvAETTYDLILKNLTKNKKLGQDnvqPRMCCRPTAFEDNLSFLDS 139 elephant shark

Feature 1        #### #           
3FUB_B       117 NLVYHILRKHSAKRCGC 133 human
2V5E_B        84 NLVYHILRKHSAKRCGC 100 human
1AGQ_A       118 SLVYHILRKHSAKRCGC 134 Norway rat
P39905       194 NLVYHILRKHSAKRCGC 210 human
AAF26684     199 NLVYHILKKHSAKRCGC 215 chicken
Q98TU0       218 SLEYHTLKKHSAKKCAC 234 zebrafish
Q06PM8       210 NLVYHTLKQHSAKKCGC 226 African clawed frog
XP_006007492 205 NLEYHTLKKHSAKKCGC 221 coelacanth
XP_007910431 140 HMAYQTLQRYSAKKCGC 156 elephant shark

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