Conserved Protein Domain Family
ANKH
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pfam07260: ANKH 
Progressive ankylosis protein (ANKH)
This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters.
Links
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Statistics
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PSSM-Id: 429370
Aligned: 3 rows
Threshold Bit Score: 705.59
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003219845   1 MVKFPALTNYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80 
XP_019218607   1 MVEFPSLSPYWPLIRFLVPLAITNVAIDLGEQALNRGIATVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80 
NP_001025430   1 MKDCLSETAYWPLIRFLLPLAITNIAIDFGEQALNRGIASVKEDKVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80 

XP_003219845  81 RDRTKAVLCMVVAGAIAAIFHTLIAYSDLGYYIINKLHHVDDSVGSKTRKAFLYLAAFPFMDAMAWTHAGILLKHKYSFL 160
XP_019218607  81 RDRRKAVFCMVAAGAIAFILHILIAYTDLGYYIINKLHHVDESVGHKTRKAFLYLAAFPLLDAMAWIHAGILLKHKYSVI 160
NP_001025430  81 KERSKAILCMAVAGVIAIILHVLIAYTDLGYYIINKLHHVDDSVGSKTRKAFLYLALFPLLDAMAWIHAGILLKHKYSLL 160

XP_003219845 161 VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDSSGPEMGGDATIKKMLGF 240
XP_019218607 161 VGSASISDVVAQIVFVAILLHSNLECVEPLLIPILSLYMGALVRFSIVGLGYYCNIHDNIPDSSGLDVGGDATIKKMLSF 240
NP_001025430 161 VGSASISDVVAQIVFVAILLQSNLECFEPLLIPILALYMGALVRFTIVGLGYYCNVHDITPESTSTDQGGDATIKKMLSF 240

XP_003219845 241 WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKMvNSSSTVS 320
XP_019218607 241 WWPLALILATQRISRPIVNLFVSRDLKGTTDATEAVAVLTATYPVGHMPYGWLTELRAVYPAFDKNNPSNKL-NAGSLVT 319
NP_001025430 241 WWPLALILATQRISRPIVNLFVSRDLKGSSASTEAVAVLTATYPVGHMPYGWLTELRAVYPAFDMNNPTNKL-TSGVMVT 319

XP_003219845 321 STHIKKFTFVCMALSLTLCFVMFWT 345
XP_019218607 320 KSHIKKFTFCCLALSLTLCFVVFWS 344
NP_001025430 320 KSHIKKFTLCCFILSLAMCFIVFWS 344
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