Conserved Protein Domain Family
DDE_Tnp_4
?
pfam13359: DDE_Tnp_4 (this model, PSSM-Id:404270 is obsolete and has been replaced by 463855)
DDE superfamily endonuclease
This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Links
?
Statistics
?
PSSM-Id: 404270
Aligned: 45 rows
Threshold Bit Score: 99.6454
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EDO37985       98 IDGFEGKCQIPQlagAIKavrfkIKAPSLVTHKMKYyndnlkchSMTLQAVTDSSGKFLD-VSTGYPGGITNTEALAMS- 175 starlet sea an...
XP_001889281  217 MDGLNLPVQTSP---DQE-----IENTTFNGWLHDH--------FVSSVFAFSAKGEIIT-CNLNAPGSWHDSRVARPIy 279 Laccaria bicol...
XP_001868759  118 LDGKHITIQAPP---N--------SGSTFFNYKKTF--------SVVLLALVDANCNFIA-VDVGAYGRNSDGGIFASS- 176 southern house...
XP_002899057   57 FDGTLVRTQRPK---D---------------FQSGKp-------SYNCLAAIDYRYKFRY-LGV-FSGSNSDQSMWNQS- 108 Phytophthora i...
XP_002907171  125 IDGSLIEIERPD---N--------FDGFY--CRKAYp-------ALNMQAIVTSDGFFLS-VDV-RPGSWSDSKCWQYS- 181 Phytophthora i...
Q54RV8         99 LDTTVFPIRT-------------MDDQFYSIKHSKR--------CLKYEAIVTLDKGTCChLTGPHVGSELDLVVYIKE- 156 Dictyostelium ...
CAR21568      127 IDGTHVKIARPHgnaR-------LECVAYSGHKKTH--------TLKYQAVTTPDGICID-LAGPFAGSQHDSFLFTNS- 189 Lachancea ther...
Q9R319        109 LDGTVIRTDRVA---APGp---nGADLRWSGKHKHH--------GGNVQVIATPDGWPIW-VSPVRPGREHDTTCARHH- 172 Streptomyces c...
jgi:Gobs_0696 100 VDGTLIRTDGCR---TKNpd--tGHDLWFSGKHKAH--------GGNVQIVSDPDGHPVV-VSEVEPGSVHDLAAARAT- 164 Geodermatophil...
tgen:AM1_2372  57 VDTFEQARERPI---DND-----EQRSYFSGKKQQH--------TFKSQIVTLPGGKDIVdAIAGKKGPTSDISVFREH- 119 Acaryochloris ...

EDO37985      176 DIYKNVKqgvilnsps--atveglqvkPIIATDASYK--LRKw---cI-CPYP----------DNNMLSPSQERFNSELG 237 starlet sea an...
XP_001889281  280 EKLRAqtp-----------------egYYLVTDTAFPrgTDQiagriR-APMKdgarlplnrlERERL----LQEDRQLL 337 Laccaria bicol...
XP_001868759  177 VLGKALAgnrlnvpeaaplpgtntltpHVIVGDEAFP--LKPy---lM-RPY-----------PGDNLDNAKRIFNYRLS 239 southern house...
XP_002899057  109 AVLGAharel-------------cppgINWLGDAGFK--PWPf---lM-VPFDe--------rGGKRLTAKQRCYNYHLS 161 Phytophthora i...
XP_002907171  182 TIGRSvgnv--------------lpagKHFIGDAGYA--LLPw---lI-VPYCer-------eEGGRLSQQQKQFNFLHS 234 Phytophthora i...
Q54RV8        157 VAHLDll------------------pgEKIFADEDFC--CNEfssklI-RPIKk--------tHETMLTNEEHCFNNWVS 207 Dictyostelium ...
CAR21568      190 GLYRRlkpalk-----------vggiqYRIFGDPAYR--SSD-----LlTVGY----------KGQNLTNGQKEYNTILS 241 Lachancea ther...
Q9R319        173 GLVEALNriaa-------------eldMPTLVDFGYE--NAGdg--fR-HPFKk--------pAGSELTEEQQTYNKVIR 226 Streptomyces c...
jgi:Gobs_0696 165 GFLGALHaaaallg-------lpalaaLAALADKGYH--GAGig--vL-TPTK-----------GRGLHSNNLIRNRLIG 221 Geodermatophil...
tgen:AM1_2372 120 QSQFAPGqg--------------------fdGDKAYV--GAQn---vQ-TPHKk--------pRGKELTPKQKAQNKKFS 165 Acaryochloris ...

EDO37985      238 -SAVHIAEDALARLRgRWNTLa--GSCLDEN-VEKIPETVLICCVLHN 281 starlet sea anemone
XP_001889281  338 -SYRQTAEWGMRTIQgTFGCL---HVPLQIAyHEIRGDLLETCARLFN 381 Laccaria bicolor S238N-H82
XP_001868759  240 -RIRRASENTFGIYMqMFRIF---NRPIQAK-PENVDKIIMAAIVLYQ 282 southern house mosquito
XP_002899057  162 -QTRILVECVFGKLKpRFKTL---HGVTDRKkHNTNARMITAAAVLHN 205 Phytophthora infestans T30-4
XP_002907171  235 -STRMAVECTFGRWKgRFRML---QCALSQEtARRSANFVVATVVLHN 278 Phytophthora infestans T30-4
Q54RV8        208 -SNGIIVKNFFKDLK-KFEILkdwRSS-----IDKHMKMVYFLTWVVN 248 Dictyostelium discoideum AX4
CAR21568      242 -GSRVSIEWFFGEVKnNFQIFn-iLGRLKVGgVRFCGAYFTIAVFLTN 287 Lachancea thermotolerans CBS 6340
Q9R319        227 -GIHGVCERANSLLKtTFKAL---R-RVSLD-PSRITKIAAAALVLLQ 268 Streptomyces coelicolor
jgi:Gobs_0696 222 -CLRAPGERGIALLKtRWKAL---G-RIRLC-PQRIGAIAKAALVLTN 263 Geodermatophilus obscurus DSM 43160
tgen:AM1_2372 166 sTRRIFVEHTIRLVR-IFRVA---QERFRLR-HDTYEQVILTVCGLVR 208 Acaryochloris marina MBIC11017
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap