Conserved Protein Domain Family
Rhomboid_SP

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pfam12595: Rhomboid_SP 
Rhomboid serine protease
This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.
Statistics
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PSSM-Id: 463639
Aligned: 9 rows
Threshold Bit Score: 278.295
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6PIX5        91 VSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQK-------IIDPLARG 162 house mouse
XP_003964817  94 VSKDGDST-QRWQRKSLRHCSMRYGKLKPQVIREMDLPSQDNISLTSTETPPPLYVPASQHGMQK-------IVDPLARG 165
XP_009304980  92 VSNDLDAT-QKWQRKSLRHCTQRYGKLKPQVIREMDLPSQDNLSMTSTETPPPLYVPPPHHGMQR-------IVDPLARG 163
XP_007482652  99 VSEDWDGKrQNWHRKSLHHCSMRYGKLKASCQRDLELPSQEVPSFQGTESPKACKLPK--------------IVDPLARG 164
XP_012433992  96 VSSDWEGKrQQWQRKSLQHCSMRYGKLKPA-YRDMELPSQEVPSFQATESPKPTKMPK--------------IVDPLARG 160
3_pfamImport   1 VSKDSDST-QRWRRKSLQHCSHLYGGLKPQVMRDRELHSQDNISLASTETPPPLYLPPYHHGMQRvgkrrgqIVDPLARG 79 
XP_011603031  91 VSKDSDST-QRWRRKSLQHCSHLYGGLKAQVMREMELRSQDNLSLASTETPPPLYLPPHHPsnrycg--mqrivDPLSRG 167 torafugu
CAG10778      89 VGEDCESQqQVWHRKSLRHCSQRYGRLKAQ-YREPDTASSLEPGL---DSPGTHRLPK--------------IVDPLARG 150 spotted green p...
XP_022522895  94 VSKDGDAT-QKWQRKSLRHCSMRYGKLKPQVIREMELPSQDNISLTSTETPPPLYVPSSQHGIPK-------IVDPLARG 165 Mexican tetra
Q6PIX5       163 RAFRMADDtADGLS-----APHT-PVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRG 236 house mouse
XP_003964817 166 RAFRMVEE-VDGYS-----VPQT-PITPGATSLCSFTSSRSGLNRLPRRRKRESVAKMSFRAAAALVKGRSIRESTLRRA 238
XP_009304980 164 RAFRNVDE-VDGVN-----VPQT-PITPCAASLCSFTSSRSGFNRPPRRRKRESVAKMGFRAAAALVKGRSLRDGAVRRL 236
XP_007482652 165 RAFRHPDE-VDRHHp---pLP---PLTPGVLSLSSFTSVRSGYSHLP-RRKRMSVAQMSFHAAAAILKGRSVLEPAGQKR 236
XP_012433992 161 RPFRHPDE-TDRPHtphhvLP---PLTPGVVSLASFNSIRSGYGRLP-RRKRESVAHMSFKAAAALLRGRSVLEPLAPKR 235
3_pfamImport  80 RAFRLVEE-VDGFS-----VPQT-PITPGTASLCSLSSSRSALNWLPRRRKRESVAVMSLKAAAALMKGRPLADSTSGRP 152
XP_011603031 168 RAFRVVEE-ADGSS-----VPQT-PVTPCTASLCSYSSSRSALNRLPRRRKRESVAVMSLKAAASLMKGRTLGGSTAHRC 240 torafugu
CAG10778     151 RAFRCPEE-MEPRSprtphVPQGgPATPGVASLSSFTSQRSGFSRFP-RRKRESVARMSIRAASNLMRAS---------- 218 spotted green p...
XP_022522895 166 RAFRMVEE-VDGYS-----VPQT-PITPGAASLCSFTSSRSGLNRIPRRRKRESVAKMSFRAAAALVKGRSIRESTLRRA 238 Mexican tetra
Q6PIX5       237 Q---RRSFTPASFLEEDMVDFPDELDTSFFAREGVlHEEMSTYPDEVFESPS 285 house mouse
XP_003964817 239 Q---RRSFTPASFMEEDIVDFPDELDTSFFARDILmHEELSTYADEVFESPS 287
XP_009304980 237 P---RRSFAAASFLDEDTVDFPDELDTSFFAKDGVtHEELSTYADEVFESPS 285
XP_007482652 237 Rv-iKRSFAYPSFHDEDVVDGADTFDSSFFSKIDM--QEMYSMPDDVFESPP 285
XP_012433992 236 Rs--KRSFLYPSFMDEDMVDAADTLDSSFFSKMDM-HDETYSMPDDVFESPP 284
3_pfamImport 153 R---RRSFMPSSFLEDDTVDSTDELDTSFFTREGL-HDELYSYVDEVFETPS 200
XP_011603031 241 R---RRSFMPPSFFEEDSVDFLDDLDTSFFNReglhdelssyaddvfetase 289 torafugu
CAG10778     219 RslpKRSFVRPSWVEEDTVDFAGISESVFFSKGDA-HEELLSMADDVFESPP 269 spotted green pufferfish
XP_022522895 239 H---RRSFTPASFIEEDVVDFPDELDTSFFARDVLmQEEMSTFHDEVFESPS 287 Mexican tetra
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