Conserved Protein Domain Family
Filo_glycop

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pfam01611: Filo_glycop 
Filovirus glycoprotein
This family includes an extracellular region from the envelope glycoprotein of Ebola and Marburg viruses. This region is also produced as a separate transcript that gives rise to a non-structural, secreted glycoprotein, which is produced in large amounts and has an unknown function. Processing of this protein may be involved in viral pathogenicity.
Statistics
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PSSM-Id: 279888
Aligned: 2 rows
Threshold Bit Score: 596.449
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P35253   1 MKTTCFLISLILIQGTKNLPILEIASNN-QPQNVDS-VCSGTLQKTEDVHLMGFTLSGQKVADSPLEASKRWAFRTGVPP 78  Marburg virus - Musok...
Q05320  15 KRTSFFLWVIILFQRTFSIPLGVIHNSTlQVSDVDKlVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPP 94  Ebola virus - Mayinga...
P35253  79 KNVEYTEGEEAKTCYNISVTDPSGKSLLLDPPTNIRDYPKCKTIHHIQGQNPHAQGIALHLWGAFFLYDRIASTTMYRGK 158 Marburg virus - Musok...
Q05320  95 KVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGT 174 Ebola virus - Mayinga...
P35253 159 VFTEGNIAAMIVNKtVHKMIFSRQ------------GQGYrhmnLTSTNKYwtSSNGTQTNDTgcfgalqEY-NSTKNQT 225 Marburg virus - Musok...
Q05320 175 TFAEGVVAFLILPQ-AKKDFFSSHplrepvnatedpSSGY----YSTTIRY--QATGFGTNET-------EYlFEVDNLT 240 Ebola virus - Mayinga...
P35253 226 capskippplptarpEIKLTS--TPTDATKLNTTdpssddedLATSGSGSgerepHTTSDAVTKqglsstmpptpspqpS 303 Marburg virus - Musok...
Q05320 241 ---------------YVQLESrfTPQFLLQLNET--------IYTSGKRS-----NTTGKLIWK---------------V 277 Ebola virus - Mayinga...
P35253 304 TPQQggnNTNHSQDAVTElDKNNTTAQPSMPPHNTTTIST---NNTSKHNFSTLSAPLQNTTNDNTQSTITENEQ 375 Marburg virus - Musoke, Ke...
Q05320 278 NPEI---DTTIGEWAFWE-TKKNLTRKIRSEELSFTVVSNgakNISGQSPARTSSDPGTNTTTEDHKIMASENSS 348 Ebola virus - Mayinga, Zai...
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