Conserved Protein Domain Family
PGC7_Stella

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pfam15549: PGC7_Stella (this model, PSSM-Id:406086 is obsolete and has been replaced by 464759)
PGC7/Stella/Dppa3 domain
The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.
Statistics
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PSSM-Id: 406086
Aligned: 12 rows
Threshold Bit Score: 120.355
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFB12861       1 MD-PLQKCNSTSIPES-----SPMISEETSREVTAASPPSFSELLMMGLGDLK--TSPGAKYPAPLPEGLLQQ------- 65  giant panda
2_pfamImport   1 ME-PKKTVTPSLSSDS-----CLTATKEIPQEVTSTYQISFSEIQKLDLINFN--PDPGSSYLTPLPEDLVQL------- 65 
A9Q1J7         1 MD--SSEDNPTWTLES-----LKTSIDDASQAMQVATQLS--EMLATNLSNLT--LNPSIKLP-YLPEYPSQLt------ 62  cattle
3_pfamImport   1 MD-PSQTFDPTLIPES-----SEMLTEEDSQAVSESSHNFS-ETLIKNLSKLS--LNPSTSFPPSLPEGFTQQqdre--- 68 
Q8QZY3         1 MEePSEKVDPMKDPET-----PQKKDEEDALDDTDVLQP---ETLVKVMKKLT--LNPGVK--RSARRRSLRNriaavpv 68  house mouse
ELK03273       1 MD-PLQKHSSALISES-----SPMMSKEPSREVAVATHPSFLQLLMLSLSDLN--PSPGTSYPAH-PKGLRQQ------- 64  black flying fox
EHB18283       1 MD-PLQKWNPGLISGS-----SQMPTTETSQEGAAASQPSSSEQLMMGLGDLS--ISPGSNPAVPLQEGLFQQ------- 65  naked mole-rat
XP_003500230   1 MD-PLQKWDPMSISMP-----SRMATVTSSQAASAGSHPSSSEKLSMGLSGLRliRSPGPGVSAPVSEGLLQQ------- 67  Chinese hamster
NP_001158155   1 MD-PLQKWDPMSISVP-----SCIATVSSSQEASAAPQPSSSEKLSMGLSILSvsPSPRSSVPASLSEGLFQQ------- 67  house mouse
XP_004064247   1 MD-PLQKWNPASPSKS-----SLMTAAETSQEGPAPSQPSYSEQPMMGLSNLS--PGPGPSQAVPLPEGLLRQ------- 65  western lowland...
XP_008246735   1 MD-PLQNWSPGFAADA-----SPMAMAETSADSRAASQPPSAEQLVWGLGNMN--PGAGPDLPVPPPAGLPQQ------- 65  rabbit
NP_001041329   1 MDePSEKVDPVVNPETqmydgSQREDEGDSPDDSEILQP---ETLVKVMKKLT--LNPSAKPTKYHRRQRVRLqvksqpv 75  Norway rat
EFB12861      66 ------RYRDEKTL--QERRWERSASPQRKRTLLGHARRRHLDHVAPYRVERKARIsSSAGDRD-QNRf----rCECRYC 132 giant panda
2_pfamImport  66 ------QYRDEITQkdRQRKWERSVLPQRKRSFMEHIRQKTLNHMAPYRVEREGKT-LYSHNKD-QSR------CKCHYY 131
A9Q1J7        63 -----gQLPSEKTP--HRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRSDSQRQlQQQEDTEiRSRvrr-fqCTCSYC 134 cattle
3_pfamImport  69 --ssfqDMRDGWPL--RKRRGVRTLLSVQRE------RMARLRYILINKFSPLARRlKDAELKGvQNDyskpfkCRCSYC 138
Q8QZY3        69 enksekIRREVQSA--FPKRRVRTLLSVLKDPIAKMRRLVR--------IEQRQKRlEGNE----FERdsepfrCLCTFC 134 house mouse
ELK03273      65 ------RHRDGKTL--QERQWEKSVAPQRKKAFLEHMRGRRLDHVIPYQVQRETRI-TSSGDGD-QNRf----rSDXXXX 130 black flying fox
EHB18283      66 ------QHRE-KTL--LEQHWERLGFPQKKKAFLGHFRRRHRDHMAPYPVERETRI-SFPGDRA-QNQf----rCQCRYC 130 naked mole-rat
XP_003500230  68 ------QAREKKAL--WQQYWEKQGFPQRKKVFLRHSGRWHWDHMTPYLLARDVRG-SPSGGNT-QNLq----qC----- 128 Chinese hamster
NP_001158155  68 ------QAREKKAL--WQQYWEKQGFPQRKKVFLRHSRRWHRDHMAPYLLERDLRG-FPSGDKA-QNQl----rC----- 128 house mouse
XP_004064247  66 ------RYREEKTL--EERRWERLEFLQRKKAFLRHVRRRHRDHMAPYAVGREARI-SPLGDRS-QNRf----rCECRYC 131 western lowland...
XP_008246735  66 ------QYREAKT---QQRWYERLPPPQGKKELLGHIRRRHRDHRAPYPASQEAKL-SPSGDRP-QNRf----hCECRYC 130 rabbit
NP_001041329  76 enrserIMREVQSA--FPRRRVRTLLSVLKDPIARMRRFVR--------IEQRQRQlEGNE------RrdepfrCLCTFC 139 Norway rat
EFB12861     133 QSHRPNVPGMPAERKgaphPSSW--DTLVQGLSGLTLS 168 giant panda
2_pfamImport 132 QIDREETASNTNGKD----PAFW--KMLVQGFNQMTLN 163
A9Q1J7       135 QFKRN--------------PSDDnyENYYNTTYS-NYA 157 cattle
3_pfamImport 139 VSNNWD-------------PSE-------------NAR 150
Q8QZY3       135 HYQRWD-------------PSE-------------NAK 146 house mouse
ELK03273     131 QSHTECLWDACGEERg---PTSFllGNLVQGLSGSTLS 165 black flying fox
EHB18283     131 QGHMPNISGVTGERNgnpsPSSW--ETLVQGLSGLTLS 166 naked mole-rat
XP_003500230 129 QGHVPNIAGMSGDRNtppnPPSW--ETLVQGLNGLTLN 164 Chinese hamster
NP_001158155 129 QGHVQNIAGMSGQKNaapnPPSW--EMLVQGLNGLTLS 164 house mouse
XP_004064247 132 QSHRPNLSGIPGESNraphPSSW--ETLVQGLSGLTLS 167 western lowland gorilla
XP_008246735 131 QSNGPNTSGLSGERGg----ASW--ETLVQGLSGLSLS 162 rabbit
NP_001041329 140 HYQRWD-------------PSE-------------NAK 151 Norway rat
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