3N3K,1VJV,4FJC,1NBF


Conserved Protein Domain Family
UCH

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pfam00443: UCH 
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Ubiquitin carboxyl-terminal hydrolase
Statistics
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PSSM-Id: 425685
Aligned: 54 rows
Threshold Bit Score: 106.758
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3N3K_A         63 TGLRNLG--NTCYMNSILQCLCN--AP----HLA-DYFNR-------NCYQDDI-----NrsnllghkgeVAEEFGIIM- 120  human
P38237        323 CGLINLG--NSCYLNSVIQSLVNggVP----NWSlDFLGSkfpldvvYPDNN------------------LKCQWIKLL- 377  Saccharomyces...
Q9S9J6         30 IGKLNAT--CVSALAMILKSIWN--IN--------------------------------------------------VF- 54   thale cress
Q9FH47        805 AGEAAAR--YNSALDMTLKALLS--IK----IFKeDLMQNsqqiqdqRQEQ-------------------VPTALQNLF- 856  thale cress
Q9S9J3        802 NGKAATR--YNSALDMMLKSLCN--IK----VLKeDLVNNrkpfsenQ----------------------VPCALRDFF- 850  thale cress
XP_004349333   70 RGLTNATgdNHCFMNGVVQLLWH--LA----PFRdAFAAVdshhcsdTQNQLDC----------------VFCALKTIF- 126 
KDO24290     1027 QGLVNLG--NTCYMNAVLQALLS--LQafvtTLRdDAWVTaltkmplPKGHWQAkavkdAy--------dFYLVFKTMI- 1093
Q86T82        341 QGFSNLG--NTCYMNAILQSLFS--LQ----SFAnDLLKQgipwkkiPLNA-------------------LIRRFAHLLv 393  human
Q8C0R0        341 QGFSNLG--NTCYMNAILQSLFS--LQ----SFAnDLLKQsipwkkiPFNA-------------------LIRRFANLLi 393  house mouse
O44787        256 VGLNNIK--ANDYCNAILQALSA--VR----PLR-NWFLKesnytsiKRPPGDKl---tL----------LPQRFGELI- 312  Caenorhabditi...
3N3K_A        121 ----------KALW--TGq-YRYISP-KDFKITIGKINDQFA----GYSQQDSQELLLFLMDGLHEDLNKadnrkrykee 182  human
P38237        378 ----------NAMKcePElyPNGIKP-TTFKKCIGQNHQEFS----SNRQQDAMEFLTFLLDLLDKKFFS---------- 432  Saccharomyces...
Q9S9J6         55 ----------------------------------------------ASSREDESVFHEFLLNDLSLKHPL---------- 78   thale cress
Q9FH47        857 ----------TAVVs-EAiqDEGVYS-CLLSDFLTSQEEF------LSMSSDAAKVVVAVLNLWRCWKNP---------- 908  thale cress
Q9S9J3        851 ----------SAFVs-EKikEEELYG-HLLSNLLDSLEEL------HSLSSNAAEVLVAILEFCHCWKSP---------- 902  thale cress
XP_004349333  127 -------------N---NttDSHVPP-DALRSALSSVYKS-SsrfqLGDMNDAVECLEAIQSTIHSQVVGdqvk------ 182 
KDO24290     1094 -------------K--GHvqSAHLDP-SPMKAVVGKRAQVFA----NNAQQDAHEFLMNVLNELEADMKGvkaskqslh- 1152
Q86T82        394 kkdicnsetkKDLL-------------KKVKNAISATAERFS----GYMQNDAHEFLSQCLDQLKEDMEKlnktwktepv 456  human
Q8C0R0        394 kkdicnsetkKELL-------------KKVKNAISATAERFS----GYVQNDAHEFLSQCLDQLKEDMEKlnktwktepv 456  house mouse
O44787        313 ----------RKLWn-PRalRTHVSPhEMLQAVVVCSNKKFQ----FIKQNDAADFMLFLLTTLHSALNG---------- 367  Caenorhabditi...
3N3K_A        183 nndhlddfkaaehawqKHKQLNESIIVAL---------FQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTL--- 250  human
P38237        433 -----------------SSSSGIPNPNDL---------VRFMMEDRLQCNICGKVKYSYEPTEAIQIPLEENDEP----- 481  Saccharomyces...
Q9S9J6         79 ---------------------EANGVFDL---------FLNILEALPNWGLYFEVYEVAKKICNRCKLDLEYPAERSfrl 128  thale cress
Q9FH47        909 --------------------ERESLVTRL---------FTLVENKRMSCRKCRRITNSPVQSSYGIVMAADSIRELKca- 958  thale cress
Q9S9J3        903 --------------------ESESLVTRL---------FTLEEYERMSCRKCRRKPNYPEQSSYGIVMAADSIRDLEca- 952  thale cress
XP_004349333  183 ------------ddhyDSCTAPTCPVHSV---------FALRVSEHVKCSSCGAQSKDFEFEKSIHYVAVEALAEQVhhe 241 
KDO24290     1153 --------qyfggndeKAMVTPTLAPADVeallptttfFRTTVTQTLTCSSCAYRRHVKETFRELSLDFPALAAPKPpil 1224
Q86T82        457 -------sgeenspdiSATRAYTCPVITN---------LEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPL---- 516  human
Q8C0R0        457 -------lgeenlpdtSATKVFTCPVITN---------LEFEVQHSIICKACGETIPKREQFNDLSIDLPRRKKPL---- 516  house mouse
O44787        368 ------------------TDKKPSIISKT---------FRGRMRQYSRRVIPAEDTDEEKYMKLRMPEYQEKVIESPfly 420  Caenorhabditi...
3N3K_A            --------------------------------------------------------------------------------      human
P38237            --------------------------------------------------------------------------------      Saccharomyces...
Q9S9J6        129 iisas--------------------------------------------------------------------------- 133  thale cress
Q9FH47            --------------------------------------------------------------------------------      thale cress
Q9S9J3            --------------------------------------------------------------------------------      thale cress
XP_004349333  242 rkrrrktntyrlsiiapntkdappangnpraslssgsagnvedepwpagwekveapegklyfhdhnskitywtdprlrvr 321 
KDO24290     1225 ckcqkpvkrlitkkdgknkgrp---------------------------------------------------------- 1246
Q86T82            --------------------------------------------------------------------------------      human
Q8C0R0            --------------------------------------------------------------------------------      house mouse
O44787        421 ltldlpsa------------------------------------------------------------------------ 428  Caenorhabditi...
3N3K_A        251 --------------------------------------------QDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEI 286  human
P38237        482 ---------------------------------------------QDMLERIKAYFEGQTIEFKCANCKEKVTANKKPGF 516  Saccharomyces...
Q9S9J6        134 ------------------------------------slrevksaFKDFTFENIIKVIKMNLKMPCDKEGCGKQSYVHRMI 177  thale cress
Q9FH47        959 ------------------------------------------fgNIKFVDILKLIRLGYKMLCDNKKGGCGKKSYVDHII 996  thale cress
Q9S9J3        953 ------------------------------------------lgNIMFEDTLKVIRMNNEMICDVGTGGCGERNLVHHTI 990  thale cress
XP_004349333  322 aglphgwdfsttetgemyyvdhvtkgsawtpplatrsiqatlheCIPPVALDHLLNAVNESDVRSCQKTCGTVNTIVPTL 401 
KDO24290     1247 -------------------fikcnqfpqceffawddappeppapALDVPQLLTTHFQSHTVDLKCEKCADGASVNVTATI 1307
Q86T82        517 --------------------------------------------PPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKF 552  human
Q8C0R0        517 --------------------------------------------PPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKF 552  house mouse
O44787        429 ----------------------------------plyrdvqlqnIIPQVPLSTLLEKFDGKTEKEYPTYNDNNIMKRFEL 474  Caenorhabditi...
3N3K_A        287 WKLPPVL-------------------------------LVHLKRFSYDGR--WKQKLQTSVDFP------LeNLDLS-QY 326  human
P38237        517 KSLPQTL-------------------------------ILNPIRIRLQNW--IPVKTSNELSLPglidrdD-MLDVS-SY 561  Saccharomyces...
Q9S9J6        178 TKLPSVF-------------------------------TIALE----------WTKNETAGEIFdtvsvlAtEIDVNvIY 216  thale cress
Q9FH47        997 RRCPPIF-------------------------------TIVLE----------WEKSETEKEISettkalDwEIDIS-RL 1034 thale cress
Q9S9J3        991 SRCPPIF-------------------------------TIVLE----------WEKNETEIEIYettnalHwEIDIS-RL 1028 thale cress
XP_004349333  402 HSAPSVFalalvwgstrpqselisevlellapaldlatVFHRTRPTE--P---KAKRRWSLADP------DnRLNAD-AF 469 
KDO24290     1308 THAPPIL-------------------------------VLHLKRFEISTAsmTLVKRNDIVVAP------T-SVDLS-VF 1348
Q86T82        553 NRLPRVL-------------------------------ILHLKRYSFNVAlsLNNKIGQQVIIP------R-YLTLS-SH 593  human
Q8C0R0        553 NRLPRVL-------------------------------ILHLKRYSFNVAlsLNNKLGQQVIIP------R-FLTLA-SH 593  house mouse
O44787        475 LQLPDFL-------------------------------IITYKRFQKNQW--FVEKNPTIVNFP--------IANVD-FY 512  Caenorhabditi...
3N3K_A        327 VI---GPK-NNLKK------------------------------------------------------------------ 336  human
P38237        562 LSqgfDPQtENLLPdedenrssftpnqcsisqliemgftqnasvralfntgnqdaesamnwlfqhmddpdlndpfvpppn 641  Saccharomyces...
Q9S9J6        217 QCegdIRYtK---------------------------------------------------------------------- 226  thale cress
Q9FH47       1035 YEeglETNtN---------------------------------------------------------------------- 1044 thale cress
Q9S9J3       1029 Yeg-lEPNtN---------------------------------------------------------------------- 1037 thale cress
XP_004349333  470 AAkdaLP------------------------------------------------------------------------- 476 
KDO24290     1349 QApnaKPApK---------------------------------------------------------------------- 1358
Q86T82        594 CTentKPPfTLGWSahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrlcemlgne 673  human
Q8C0R0        594 CTestKPPvTLGWSapvaisrplracqmmnscitspsapskkftfkskssvtscldsdsedelkrsvvlsqrlcdlpgne 673  house mouse
O44787        513 DClakDARaNHKYTt----------------------------------------------------------------- 527  Caenorhabditi...
3N3K_A            --------------------------------------------------------------------------------      human
P38237        642 vpkkdk-------------------------------------------------------------------------- 647  Saccharomyces...
Q9S9J6            --------------------------------------------------------------------------------      thale cress
Q9FH47            --------------------------------------------------------------------------------      thale cress
Q9S9J3            --------------------------------------------------------------------------------      thale cress
XP_004349333      --------------------------------------------------------------------------------     
KDO24290          --------------------------------------------------------------------------------     
Q86T82        674 qqqedlekdsklcpiepdkselensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpd 753  human
Q8C0R0        674 qyqedvekdlklcrlepgkaelensgfdrmseeevlaavleisrreaspvlspedddkptsspdtgfaeddipempenpd 753  house mouse
O44787            --------------------------------------------------------------------------------      Caenorhabditi...
3N3K_A            --------------------------------------------------------------------------------      human
P38237        648 ---------------------------------------------------------------revdevsltsmlsmgln 664  Saccharomyces...
Q9S9J6            --------------------------------------------------------------------------------      thale cress
Q9FH47            --------------------------------------------------------------------------------      thale cress
Q9S9J3            --------------------------------------------------------------------------------      thale cress
XP_004349333      --------------------------------------------------------------------------------     
KDO24290          --------------------------------------------------------------------------------     
Q86T82        754 tmetekpktiteldpasfteitkdcdenkenktpegsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddl 833  human
Q8C0R0        754 ameieksktitepgpasfteitkdcdenkenktpegsqgevdwlqqydvdrereeqelqqalaqslqeqeaweqkedddl 833  house mouse
O44787            --------------------------------------------------------------------------------      Caenorhabditi...
3N3K_A        337 -------------------------------------------------------YNLFSVSNHYG-G-------LDGGH 353  human
P38237        665 pnlcrkalilnngdvnrsvewvfnnmdddgtfpepevpneeqqqkkdlgystakpYALTAVICHKGnS-------VHSGH 737  Saccharomyces...
Q9S9J6        227 -------------------------------------------------------YRLVSMVRAKNnSnvniqvcLHGNR 251  thale cress
Q9FH47       1045 -------------------------------------------------------YRLVSMV---GcG-------EGEEE 1059 thale cress
Q9S9J3       1038 -------------------------------------------------------YRLVSMSENLGmQig----cVEEGE 1058 thale cress
XP_004349333  477 -------------------------------------------------------MSLTGLVCYYG------------KH 489 
KDO24290     1359 -------------------------------------------------------YRLKSIVRHLGrT-------AGEGH 1376
Q86T82        834 kratelslqefnnsfvdalgsdedsgnedvfdmeyteaeaeelkrnaetgnlphsYRLISVVSHIGsT-------SSSGH 906  human
Q8C0R0        834 kratelslqefnnsfldslgsdedsgnedvfdmeyteaeaeelkrnaetgalphsYRLISVVSHIGsT-------SSSGH 906  house mouse
O44787        528 -------------------------------------------------------YDLVANVVHEG-T-------FKDGN 544  Caenorhabditi...
3N3K_A        354 YTA------YCK--NAaRQR-------WFKFDDHEVSDIS-V------------SSVKS----SAAYILFY 392  human
P38237        738 YVV------FIR-------KlvadkwkWVLYNDEKLVAADsIed--------mkK---------NGYIYFY 778  Saccharomyces cerevisi...
Q9S9J6        252 YNC--------V--AYeNNR-------WVRYLRSEIEVI--GdwenvvsiclknI---------RPQILFF 294  thale cress
Q9FH47       1060 HVC--------L--AYeKNR-------WVNLRRECFAGEDvGdwknvvrfcgerKV--------RPEILIY 1105 thale cress
Q9S9J3       1059 YIC--------M--AYeKNR-------WVSRRHEASAEEVvGnwksvvkicgerKI--------RSEVLFY 1104 thale cress
XP_004349333  490 YIAffynprDRM---------------WMMYDDATVKPVGpTwasliakckaskF---------QPAVLLY 536 
KDO24290     1377 YITdvh-nqATK---------------WTRYNDALVTEVDqA-------------AVLTgpgaETGYLLFY 1418
Q86T82        907 YISdvydikKQA---------------WFTYNDLEVSKIQeA-------------AVQSdr-dRSGYIFFY 948  human
Q8C0R0        907 YISdvydikKQA---------------WFTYNDLEVSKIQeA-------------AVQSdr-dRSGYIFFY 948  house mouse
O44787        545 Y--------RIQivHEgSGK-------WFELEDLHVKDLLpQ------------MIVLA-----ESYIQIW 583  Caenorhabditis elegans
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