1E8A,1IRJ,1MR8,1XK4


Conserved Protein Domain Family
calgranulins

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cd05030: calgranulins 
Click on image for an interactive view with Cn3D
Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, contains only S-100 EF-hand domains, other EF-hands have been modeled separately. These proteins are expressed mainly in granulocytes, and are involved in inflammation, allergy, and neuritogenesis, as well as in host-parasite response. Calgranulins are modulated not only by calcium, but also by other metals such as zinc and copper. Structural data suggested that calgranulins may exist in multiple structural forms, homodimers, as well as hetero-oligomers. For example, the S100A8/S100A9 complex called calprotectin plays important roles in the regulation of inflammatory processes, wound repair, and regulating zinc-dependent enzymes as well as microbial growth.
Statistics
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PSSM-Id: 240156
Aligned: 16 rows
Threshold Bit Score: 122.071
Created: 9-Feb-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ bindingdimerization
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1E8A_A, Human S100A12 bound with calcium, contacts at 3.5A.
  • Comment:the N-terminal EF hand is a S100 specific feature while the C-terminal canonical EF hand is similar to the EF hands in calmodulin, troponin C, and parvalbumin
  • Comment:the second binding site (C-terminal EF hand) has a greater affinity for Ca2+ than the first (N-terminal EF hand)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #    #  #    #                              # # # #    #       
1E8A_A      1 TKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELAntikni-kdkavIDEIFQGLDANQDEQVDFQEFISLVAI 79  human
1IRJ_A      5 SQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQnflkkenknekvIEHIMEDLDTNADKQLSFEEFIMLMAR 84  human
P28783      6 SQMESSIETIINIFHQYSVRLGHYDTLIQKEFKQLVQKELPnflkkqkkneaaINEIMEDLDTNVDKQLSFEEFIMLVAR 85  cattle
P50116      7 SQLERSISTIINVFHQYSRKYGHPDTLNKAEFKEMVNKDLPnflkrekrnenlLRDIMEDLDTNQDNQLSFEECMMLMGK 86  Norway rat
399173      7 SQMERSITTIIDTFHQYSRKEGHPDTLSKKEFRQMVEAQLAtfmkkekrnealINDIMEDLDTNQDNQLSFEECMMLMAK 86  house mouse
XP_547585 228 SQLECSIETIINIFHQYSVRLEHPDKLNQKEMKQLVKKELPnflkkqkkndnaINKIMEDLDTNGDKELNFEEFSILVAR 307 dog
2493415     2 TKLEDHLEGIINIFHQYSVRVGHFDTLNKRELKQLITKELPktlqnt-kdqptIDKIFQDLDADKDGAVSFEEFVVLVSR 80  cow
1173338     3 SELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPqfvq-----ninIENLFRELDINSDNAINFEEFLAMVIK 77  house mouse
P50115      3 TELEKALSNVIEVYHNYSGIKGNHHALYRDDFRKMVTTECPqfvq-----nknTESLFKELDVNSDNAINFEEFLVLVIR 77  Norway rat
126659     12 SELEKAIDVIIDVFHQYSRREGDKDTLTRKELKLLIEKQLAnylkhv-knqvsIDQIFKDLDNNKDQQLSFGEVMLLIIR 90  chicken
Feature 1              
1E8A_A     80 ALKAAHYHT 88  human
1IRJ_A     85 LTWASHEKM 93  human
P28783     86 LTVASHEEM 94  cattle
P50116     87 LIFACHEKL 95  Norway rat
399173     87 LIFACHEKL 95  house mouse
XP_547585 308 LTVASHEEM 316 dog
2493415    81 VLKTAHIDI 89  cow
1173338    78 VGVASHKDS 86  house mouse
P50115     78 VGVAAHKDS 86  Norway rat
126659     91 VTVATHEHL 99  chicken

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