L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase
This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.
Feature 1: active site [active site], 5 residue positions
Conserved feature residue pattern:R H D [ED] H
Evidence:
Comment:based on structures of Bacteriophage T5 L-alanoyl-d-glutamate peptidase, Enterococcus faecalis D,D-dipeptidase VanXYg, and Enterococcus faecium VanX, and on mutagenesis studies