2LIV,1USG,2LBP,1Z18,3IPC,3IP5,1Z15,4N0Q


Conserved Protein Domain Family
PBP1_ABC_LIVBP-like

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cd06342: PBP1_ABC_LIVBP-like 
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type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine)
This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.
Statistics
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PSSM-Id: 380565
Aligned: 232 rows
Threshold Bit Score: 149.214
Created: 2-Aug-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1Z18; Escherichia coli leucine-isoleucine-valine binding protein (LIVBP) binds valine, contacts at 3.5A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                              ###    
2LIV_A      4 KVAVVGAMSGPvaqYGDQEFTGAEQAVADInakggikgnKLQIAKYDDacDPKQAVAVANKVVNdGIKYVIGHLCSSSTQ 83  Escherichia coli
1Z18_A      4 KVAVVGAMSGPvaqYGDQEFTGAEQAVADInakggikgnKLQIVKYDDacDPKQAVAVANKVVNdGIKYVIGHLCSSSTQ 83  Escherichia coli K-12
ALV28308   33 RIAVAAAFSGQfapLGDQILAGARLAVEDInasgglrgeKLVLEEADDrcDPERATALANQLTGkGVQLVIGHLCSSATL 112 Pannonibacter phra...
SCM72819   27 TIGIAGPMGGSfadVGRDIKAGVEIAVAAAnarggingeKIRTVSVDDkcEAETGAAVANQLIGkGVKAVIGHACTAAAL 106 uncultured Pleomor...
OUR78360   27 KIGIAGPLSGStlnVGEMQEIGAQRAIFDInsnggllgqEIVITSVDDacEPKQAKAAAKQLVSeGVVFVVGHACSGASL 106 Alphaproteobacteri...
KHK01675   92 VVAVVGPMVGTsnsVGIQYSVGVRAALKDIngnt-llghKVNIDLFDDscTKSIAEGVAMKLAEnPPSVVIGHSCSGATI 170 Desulfovibrio sp. ...
OAN50491   15 VIALAAPLAGEs-iLGQDLKAGAEAAVKAInlgggllgePLRLELVDDhcDARQGALVATQMVKnGISAVIGHACSGASV 93  Magnetospirillum s...
ALL68405   45 TIYVVAPFSGNlkgFGVQIQNGVDAALADWnthqpaginQIRAEYLDDscDPEKAKAIAAQLVAvHAKVVLGHVCSVASL 124 Paraburkholderia c...
OBQ69907   37 PIAVAGPMTGDwavYGEEMRRGAKLAADDInakggiggcKLALTVLDDqgTPDTAVAIAKTVGRdRVRFVVGHYNSGASI 116 Mesorhizobium loti
OQW56178   26 KIGVAGPMDGSnrrLGQQLKNGVTEAVEAInastnargqKYSVNVYHDacDSEQATKIVHQAKNdGVKIIIGHFCNGSSM 105 Proteobacteria bac...
Feature 1                     ##                                                 #            
2LIV_A     84 PASDIYEdEGILMITPAAtaPELTARGYq-lILRTTGLDSDQGPTAAKYILekvkpqRIAIVHDKQQYGEGLARAVQDGL 162 Escherichia coli
1Z18_A     84 PASDIYEdEGILMITPAAtaPELTARGYq-lILRTTGLDSDQGPTAAKYILekvkpqRIAIVHDKQQYGEGLARAVQDGL 162 Escherichia coli K-12
ALV28308  113 AAAPVYAeAGRIQITVASalPQLTEARPgpgFFRLGPREDATAPFIAERLAqefagkRIGLVTDRSAYGKDFAARVKAAM 192 Pannonibacter phra...
SCM72819  107 PAARVYAgGGVLFLSTAAtnPRLTDEKVgagVFRMAIRSDREARAIADYLGkrfkgkRVAFVHDGSVYGQGLAEQAAKLF 186 uncultured Pleomor...
OUR78360  107 AVGKIYEdAGIIMISPSStnPRITDAGIs-tVFRVIGRDDEQGLVAGDYLAdnnkngNIVILHDGQAFGLGIAEFAKQQL 185 Alphaproteobacteri...
KHK01675  171 ISAPIYAkHKILQITPAStnPKVTEMGIs-tLFRMIGRDDLQGKMAAQRISerhagqRVGVLFFPSEYSEGLTQTAIAAL 249 Desulfovibrio sp. ...
OAN50491   94 PASLVYQeDGVLMLSPSSsvPKLTERGLd-lVFRLFGRDDRLADAMANHVArkyadkQIAVIHDKRSYGKGLADGFKDGL 172 Magnetospirillum s...
ALL68405  125 PASEIYAhANIPMLSAASsnAAFTERGLq-sVFRVTGRDDSQAPLVAETIVerfpgkRVVIVEETDITGRSHGEHVRSEL 203 Paraburkholderia c...
OBQ69907  117 PASQIYAkNNTLMVSPAStnPALTEFKLw-nVARTAGRDDVQGAFAAGYMAdhfpqrNLAIVSDGTPYGDGLADKARKAL 195 Mesorhizobium loti
OQW56178  106 AASRLYDdLDMLMISPASseTRLTERQLw-nTFRVAGRDDQQGAVAAQYILknfagkKIAILHDRTAYGSSLADETRKAL 184 Proteobacteria bac...
Feature 1                                             #                       #               
2LIV_A    163 kkgnANVVFFDGItagekdFSTLVARLKKEnidFVYYGG-YHPEMGQILRQARAAGlKTQFMGPEGvanvSLSNIAGESA 241 Escherichia coli
1Z18_A    163 kkgnANVVFFDGItagekdFSTLVARLKKEnidFVYYGG-YHPEMGQILRQARAAGlKTQFMGPEGvanvSLSNIAGESA 241 Escherichia coli K-12
ALV28308  193 qakgLSPALERELdagardLKPLASALKGErldVVVLGA-YATDAGHLAAALSALDmQVPLLAGDAamgmEFGAAAGEAA 271 Pannonibacter phra...
SCM72819  187 addgGAVAMTEAFtpgeksQNNLIGKIQDAavsAVVAGA-LQADAAVIAGEMRARGlNAALIGNEAlalaEFKALAGDAA 265 uncultured Pleomor...
OUR78360  186 nkrgVTEVLFDSFkpeqddYQSVVNKLVEVnadVVYIGG-YQGDIGIIIRQAKTKLpNLQLLAGDSlvnlDFITISGKAG 264 Alphaproteobacteri...
KHK01675  250 eqrgITPVARVQAspsassYAKEIAALMQQnveVLYLVG-GGLDCGIFLRQARQMEaTFAVISSDTlvsgVFLQTAGQAA 328 Desulfovibrio sp. ...
OAN50491  173 nkrkLREAVYDALsgdstaVLPLVRRLKDRgvdVVFFGG-YFDDMVQLVRVSAEQDyHPTFFTGEAaspaAFWQAAGPAA 251 Magnetospirillum s...
ALL68405  204 lkrgVAPVAILDIssp-tdIPDLVTKLRDDraqVVFYGGhQAASLGALLTQARGTGfSGQFISNDGagnkLVAETAHDAA 282 Paraburkholderia c...
OBQ69907  196 rakgHPEKLATKVrydqtnLGDLIGKMKAAkieIVFFAG-LGDQLGALIRQTDEAGlHVQFISGDAsmvrDLTERAGPAV 274 Mesorhizobium loti
OQW56178  185 naggLKERFSETFrqldrdFTGIVSRLRAEsidLVHVSG-LYDEIGPLLRQMRSHGlQTILMSGNGivarEFAGAAGPAV 263 Proteobacteria bac...
Feature 1                                                                                     
2LIV_A    242 EGLLVTKPknyd--qvpaNKPIVDAIKAKKQDpsgaFVWTTYAALQSLQaglnq--sddpAEIAKYLKAn-SVDTVMGPL 316 Escherichia coli
1Z18_A    242 EGLLVTKPknyd--qvpaNKPIVDAIKAKKQDpsgaFVWTTYAALQSLQaglnq--sddpAEIAKYLKAn-SVDTVMGPL 316 Escherichia coli K-12
ALV28308  272 SRVEVTFMadpaavpdspAREIASRMRAAGMVps-pYATDGYAAVQLFAaavdasgsfdfAPVAAALQSg-SFDTVSGTV 349 Pannonibacter phra...
SCM72819  266 EGTVFFLPfvdk--trpeAVNLILSLEERQLMpt-dTVFTAHAATEAAIaalak--ggdlAGAAAFLRKs-GAATVLGKV 339 uncultured Pleomor...
OUR78360  265 IGAKFTFGpdmr--lnpeAKDVVAVIRDEDAYepdgYTLYAYGAVQAWAqaverakttktDAVVSALKSg-KFDTVLGEI 341 Alphaproteobacteri...
KHK01675  329 EGVPFTFPpeat--qlptAASAIETIKAMGQEpv-gYTLLAYAATQVWIegvmraksfdaEQIAAAVRSe-PVLTILGEV 404 Desulfovibrio sp. ...
OAN50491  252 EGVVFASIaadp--tfegLDAIGKALIEAGRPvt-iYGLSAYAAVTVFAqavrhaksaepKAVAAALHAn-EFATPLGNV 327 Magnetospirillum s...
ALL68405  283 DGLLFTFDrnya--qassAQNAVARLKMQGNSte-gFTLNAYAAAQILSqaltsqpnstgSELARYIHSt-RFDTAIGKI 358 Paraburkholderia c...
OBQ69907  275 EGTLIVFSpedr--snpaAKDVVARFRSEGFEpe-aYTLKSYAAVQVIAggitmagvqapRLVAAAIRSgkPIPTVLGDL 351 Mesorhizobium loti
OQW56178  264 DGALFTFGpeaal-tssaAHDFFKTLSRRNVNpe-gHTIFAYAATQAIAqavaaaksaepRQVAAALKNg-TFSTALGQL 340 Proteobacteria bac...
Feature 1                         
2LIV_A    317 TWDEkGDLKG--FEFGVFDW 334 Escherichia coli
1Z18_A    317 TWDEkGDLKG--FEFGVFDW 334 Escherichia coli K-12
ALV28308  350 SFLPdGDREG--AGLSWYRW 367 Pannonibacter phragmitetus
SCM72819  340 TFDGkGDWRE--ASYAPQVW 357 uncultured Pleomorphomonas sp.
OUR78360  342 GFDKkGDVTGi-SGFVWYVF 360 Alphaproteobacteria bacterium 46_93_T64
KHK01675  405 TFDGkGDIRTayPAFAWHSW 424 Desulfovibrio sp. TomC
OAN50491  328 RFSHsGDALG--IRYQISRW 345 Magnetospirillum sp. SP-1
ALL68405  359 GFNAkGDLDT--PQEALFQW 376 Paraburkholderia caribensis MBA4
OBQ69907  352 TFDAkGDRRE--PDVAMYVW 369 Mesorhizobium loti
OQW56178  341 SFDAkGDRRQ--ASYVVYQW 358 Proteobacteria bacterium SG_bin9

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