2G46,1N3J,5H6Z,4RZ0


Conserved Protein Domain Family
SET_SpSet7-like
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cd10540: SET_SpSet7-like 
SET domain found in Schizossacharomyces pombe Set7 and similar proteins
Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).
Links
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Statistics
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PSSM-Id: 380938
Aligned: 24 rows
Threshold Bit Score: 123.517
Created: 8-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2G46; PBCV-1 histone H3-Lys 27 methyltransferase in complex with meK27 H3 peptide and cofactor product SAH, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ##                               #   ########                    
2G46_A      5 RVIVKKSpl----gGYGVFARKSFEKGELVEECLCIVRHnd-----dwGTALEDYLFSRK-------------------- 55  Paramecium bursari...
1N3J_A      5 RVIVKKSpl----gGYGVFARKSFEKGELVEECLCIVRHnd-----dwGTALEDYLFSRK-------------------- 55  Paramecium bursari...
4RZ0_A      6 KIYIGKSsl----gGLGVFSLEGIKKNEIIEICPTVSICne-----eiPRNLVDYLYEGKepsknkaivd---------- 66  Plasmodium (Lavera...
NP_661845  38 SVRIGPStv----aGRGAFALTPIKEGDIIERCPALEVTdk-----diGGELLNYVFYGSa------------------- 89  Chlorobaculum tepi...
EOR00933    2 RIISTPDk------GRGVFASQPIKIGEVVEISPVLLFTkeeytqhgqHTALDDYTFVWPdr------------------ 57  Wallemia ichthyoph...
CCX05931    9 SLALVLDtp----rGRGIFATRPIPAGSVIDTAPVIILPlcdfdnhiqHTTLLHYSYNWPipaadekklsssetlsetlp 84  Pyronema omphalode...
CUG91046   13 SLEVRSTpytgesnARGVFATKKILRGSLIERAHTIRFSaeehdahamKTVLQHYTFSAGg------------------- 73  Bodo saltans
PLX45978   21 DLVVAPCe-----fGHGIFATEHIPADTTLEECYHLRIRke-----dcSGIIDDYVYSVAadddd--------------- 75  Desulfobacteraceae...
PNR55431   44 LYEVFSTpytdeevARGVRAKQSICKGVVVEVAHCIRIPkqeyedhlrYSVLEHYLYVGRn------------------- 104 Physcomitrella patens
PRP82032   19 PLEIRNTvd----rGRGVFTTAAIPARTLIEQSPILFFPqeeyvfhgkYTQLDHYTYIWE-------------------- 74  Protostelium sp. J...

Feature 1                                                         #      #######      ####    
2G46_A     56 --------------------------------------------------NMSAMALGFGAIFNHSKd-PNARHELta-- 82  Paramecium bursari...
1N3J_A     56 --------------------------------------------------NMSAMALGFGAIFNHSKd-PNARHELta-- 82  Paramecium bursari...
4RZ0_A     67 ----------------------------------------iiinrkketsNYKLLPLGYGILYNHSDi-PNAYVEIhkin 105 Plasmodium (Lavera...
NP_661845  90 -------------------------------------------------eDRRLIAMGYGMMFNHSSn-PNVAYYRedt- 118 Chlorobaculum tepi...
EOR00933   58 -------------------------------------------------sGRMGLAMGIGSMFNHHKq-PNVSYSInt-- 85  Wallemia ichthyoph...
CCX05931   85 qtppdtppdtlsntssktvskssskeslnspnvpaddttnsssktlpkttLTQAIVLGLGSMFNHSVikQNVGWKRnl-- 162 Pyronema omphalode...
CUG91046   74 --------------------------------------------------GEYYLALGIGSLFNHRDp-PNVEFRIhr-- 100 Bodo saltans
PLX45978   76 ---------------------------------------------sqessECYSLPLGCGSIFNHSDe-HNTEYWHda-- 107 Desulfobacteraceae...
PNR55431  105 --------------------------------------------------GCMLMALGVGSLFNHSKq-PNLYFAIdh-- 131 Physcomitrella patens
PRP82032   75 --------------------------------------------------GGYALALGLGSMFNHNKe-PNVGYMRdk-- 101 Protostelium sp. J...

Feature 1                                     # #######
2G46_A     83 ------------glKRMRIFTIKPIAIGEEITISYGDDYWL 111 Paramecium bursaria Chlorella virus 1
1N3J_A     83 ------------glKRMRIFTIKPIAIGEEITISYGDDYWL 111 Paramecium bursaria Chlorella virus 1
4RZ0_A    106 knqikqkqdvtvsnNVMIVYAYNNIQKDDEILISYGHSWWK 146 Plasmodium (Laverania)
NP_661845 119 -----------ptgPELIIYALRNIAEGEEMYYNYGDDWWK 148 Chlorobaculum tepidum TLS
EOR00933   86 ------------htLTITFKTTRHININDELCISYGPESKL 114 Wallemia ichthyophaga EXF-994
CCX05931  163 ------------eaQTITYTALRDIREGEELLISYGAHLTF 191 Pyronema omphalodes CBS 100304
CUG91046  101 ------------gtQTISYLACSDIEVDEELCIFYGKNLWF 129 Bodo saltans
PLX45978  108 ------------erDLIVFHTIKDVSAGEQLFINYGKDWWE 136 Desulfobacteraceae bacterium
PNR55431  132 ------------dhLVIRYEAARNIAAHEELTICYGSESKL 160 Physcomitrella patens
PRP82032  102 ------------ekGFIVYTTLREIAVGEELTIHYGIVLFR 130 Protostelium sp. Jena Gg-2016a

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